YDR401W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR401W / YDR401W

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:4.47|P-value:6.03E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:4.47|P-value:5.80E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:7.84|P-value:5.99E-15 ID:SGTC_264|Compound:promethazine|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.11|P-value:9.22E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.17|P-value:7.60E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.29|P-value:6.43E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.18|P-value:9.37E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.97|P-value:5.15E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:4.52|P-value:4.61E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.06|P-value:3.53E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.23|P-value:8.08E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.47|P-value:6.03E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:4.47|P-value:5.80E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:7.84|P-value:5.99E-15 ID:SGTC_264|Compound:promethazine|FD-Score:3.53|P-value:2.74E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.11|P-value:9.22E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.17|P-value:7.60E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.29|P-value:6.43E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.18|P-value:9.37E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.97|P-value:5.15E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:4.52|P-value:4.61E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.06|P-value:3.53E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.23|P-value:8.08E-4

Top fitness defect scores for YDR401W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 7.84 38.4 µM 5.99E-15 DNA intercalators 9 2.17E-15
2 SGTC_877 0771-0151 4.52 33.1 µM 4.61E-6 10 3.03E-6
3 SGTC_144 4161-2749 4.47 112.4 µM 5.80E-6 DNA intercalators 20 3.83E-6
4 SGTC_143 4032-1194 4.47 15.7 µM 6.03E-6 41 3.99E-6
5 SGTC_1046 2001-0062 4.06 216.0 µM 3.53E-5 14 2.47E-5
6 SGTC_868 0527-0199 3.97 213.0 µM 5.15E-5 fatty acid desaturase (OLE1) 27 3.64E-5
7 SGTC_640 3381-0960 3.74 37.1 µM 1.27E-4 16 9.25E-5
8 SGTC_2152 5568786 3.55 200.0 µM 2.55E-4 23 1.89E-4
9 SGTC_264 promethazine 3.53 12.5 mM 2.74E-4 DNA intercalators 69 2.04E-4
10 SGTC_818 4072-2707 3.29 53.5 µM 6.43E-4 32 4.93E-4
11 SGTC_1648 st011736 3.27 69.8 µM 6.88E-4 PDR1 33 5.29E-4
12 SGTC_3145 9085516 3.23 49.5 µM 8.08E-4 fatty acid desaturase (OLE1) 60 6.24E-4
13 SGTC_821 1114-0266 3.18 29.2 µM 9.37E-4 53 7.27E-4
14 SGTC_2762 leflunomide 3.15 42.1 µM 0.00106 66 8.25E-4
15 SGTC_1880 MG-132 3.14 525.0 µM 0.00110 40 8.58E-4
16 SGTC_2287 7945887 3.10 168.8 µM 0.00126 32 9.84E-4
17 SGTC_1515 3460-0031 3.04 42.1 µM 0.00151 DNA intercalators 40 0.00119
18 SGTC_122 0236-0016 2.94 402.4 µM 0.00203 RNA processing & uracil transport 101 0.00162
19 SGTC_3141 9094609 2.89 49.5 µM 0.00241 iron homeostasis 99 0.00193
20 SGTC_1659 st012954 2.84 42.1 µM 0.00281 50 0.00226

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 1.27E-102 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.340 1.91E-91 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.333 1.27E-87 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.306 1.62E-73 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.300 1.42E-70 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.291 1.47E-66 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.287 2.03E-64 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.285 8.36E-64 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.282 1.69E-62 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.258 4.67E-52 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.237 6.46E-44 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.235 3.43E-43 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.225 8.81E-40 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.222 1.31E-38 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.221 2.29E-38 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene