YDR406W / PDR15

Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR406W / PDR15

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:2.98|P-value:8.47E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.65|P-value:4.50E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.78|P-value:3.31E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.10|P-value:5.16E-27 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.01|P-value:6.06E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.15|P-value:4.51E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.54|P-value:9.45E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.48|P-value:9.34E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.92|P-value:1.72E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.97|P-value:1.36E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-4.14|P-value:4.46E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.33|P-value:2.39E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.46|P-value:9.08E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.58|P-value:8.01E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.00|P-value:6.40E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:2.97|P-value:8.63E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.08|P-value:5.74E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.74|P-value:3.01E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.21|P-value:4.35E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.72|P-value:3.24E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.46|P-value:3.86E-9 ID:SGTC_2257|Compound:7960413|FD-Score:3.26|P-value:2.95E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-2.99|P-value:6.65E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.01|P-value:7.58E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.24|P-value:3.14E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.66|P-value:5.56E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.82|P-value:3.64E-10 ID:SGTC_2834|Compound:9001755|FD-Score:3.84|P-value:2.53E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.52|P-value:8.85E-7 ID:SGTC_3254|Compound:9136651|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.55|P-value:6.96E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-4.68|P-value:2.71E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:2.98|P-value:8.47E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.65|P-value:4.50E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.78|P-value:3.31E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.10|P-value:5.16E-27 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.01|P-value:6.06E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.15|P-value:4.51E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.54|P-value:9.45E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.48|P-value:9.34E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.92|P-value:1.72E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.97|P-value:1.36E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:-4.14|P-value:4.46E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.98|P-value:1.34E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.33|P-value:2.39E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.46|P-value:9.08E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.58|P-value:8.01E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.00|P-value:6.40E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:2.97|P-value:8.63E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.08|P-value:5.74E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.74|P-value:3.01E-5 ID:SGTC_2035|Compound:5154463|FD-Score:4.21|P-value:4.35E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.72|P-value:3.24E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.46|P-value:3.86E-9 ID:SGTC_2257|Compound:7960413|FD-Score:3.26|P-value:2.95E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-2.99|P-value:6.65E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.01|P-value:7.58E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.24|P-value:3.14E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.66|P-value:5.56E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.82|P-value:3.64E-10 ID:SGTC_2834|Compound:9001755|FD-Score:3.84|P-value:2.53E-5 ID:SGTC_3202|Compound:9113761|FD-Score:4.52|P-value:8.85E-7 ID:SGTC_3254|Compound:9136651|FD-Score:3.08|P-value:5.91E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.55|P-value:6.96E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-4.68|P-value:2.71E-7

Top fitness defect scores for YDR406W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_219 mitoxanthrone 10.10 164.4 µM 5.16E-27 DNA intercalators 7 3.28E-24
2 SGTC_2831 7999036 5.82 19.5 µM 3.64E-10 6 2.98E-9
3 SGTC_2103 5378138 5.46 10.0 µM 3.86E-9 3 2.43E-8
4 SGTC_3202 9113761 4.52 49.5 µM 8.85E-7 27 3.10E-6
5 SGTC_1529 apigenin 4.33 74.0 µM 2.39E-6 27 7.53E-6
6 SGTC_2035 5154463 4.21 94.6 µM 4.35E-6 12 1.28E-5
7 SGTC_1528 arabinosylhypoxanthine 3.98 74.6 µM 1.34E-5 17 3.50E-5
8 SGTC_1506 4226-2149 3.97 212.0 µM 1.36E-5 30 3.57E-5
9 SGTC_1356 1502-0781 3.92 85.8 µM 1.72E-5 fatty acid desaturase (OLE1) 16 4.39E-5
10 SGTC_1833 st055984 3.91 71.0 µM 1.80E-5 19 4.57E-5
11 SGTC_2834 9001755 3.84 58.4 µM 2.53E-5 41 6.19E-5
12 SGTC_143 4032-1194 3.78 15.7 µM 3.31E-5 73 7.88E-5
13 SGTC_2592 piperlongumine 3.66 83.3 µM 5.56E-5 TSC3-RPN4 53 1.25E-4
14 SGTC_1631 benzylvanillin 3.58 81.9 µM 8.01E-5 Golgi 39 1.74E-4
15 SGTC_1030 k029-0042 3.54 36.7 µM 9.45E-5 TSC3-RPN4 42 2.02E-4
16 SGTC_1980 st071811 3.52 45.7 µM 1.02E-4 RPP1 & pyrimidine depletion 32 2.16E-4
17 SGTC_183 3914-0051 3.48 30.6 µM 1.21E-4 60S ribosome export 35 2.52E-4
18 SGTC_887 0885-0007 3.45 9.6 µM 1.39E-4 endomembrane recycling 56 2.84E-4
19 SGTC_2563 tomatine 3.33 8.5 µM 2.26E-4 83 4.42E-4
20 SGTC_1376 2910-0861 3.31 41.3 µM 2.43E-4 44 4.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 1.55E-30 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.195 3.70E-30 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.165 7.55E-22 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.162 3.32E-21 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
0.160 9.55E-21 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.156 9.34E-20 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.147 1.23E-17 YDR405W MRP20 hom Mitochondrial ribosomal protein of the large subunit
0.138 1.07E-15 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.126 2.24E-13 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.120 2.85E-12 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.115 2.87E-11 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.114 3.97E-11 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.114 4.09E-11 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.112 8.47E-11 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.110 1.93E-10 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele