YDR411C / DFM1

Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR411C / DFM1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.89|P-value:6.98E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.12|P-value:2.42E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.65|P-value:1.02E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.14|P-value:2.26E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.46|P-value:5.61E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.24|P-value:1.48E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.77|P-value:1.27E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.73|P-value:1.52E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.13|P-value:2.32E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.87|P-value:7.62E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:3.45|P-value:5.95E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.99|P-value:4.22E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.80|P-value:8.89E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.26|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.60|P-value:2.88E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.05|P-value:3.29E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.08|P-value:2.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.13|P-value:5.11E-20 ID:SGTC_1120|Compound:ficusin|FD-Score:6.20|P-value:2.26E-12 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.86|P-value:8.27E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:9.15|P-value:7.94E-25 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.60|P-value:2.05E-10 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.78|P-value:4.60E-8 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.86|P-value:7.06E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.69|P-value:1.89E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:2.92|P-value:5.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.19|P-value:1.42E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.26|P-value:1.37E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-4.50|P-value:2.51E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.32|P-value:7.06E-7 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:2.81E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.44|P-value:3.48E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-3.23|P-value:1.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.29|P-value:1.17E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.82|P-value:8.24E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.15|P-value:2.22E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.96|P-value:1.37E-11 ID:SGTC_2030|Compound:5175110|FD-Score:3.43|P-value:6.31E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:1.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.70|P-value:1.86E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.95|P-value:5.07E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.74|P-value:1.48E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.97|P-value:4.60E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-2.88|P-value:6.34E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.93|P-value:5.45E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.03|P-value:3.56E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.89|P-value:7.18E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.91|P-value:6.12E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.99|P-value:1.10E-11 ID:SGTC_2834|Compound:9001755|FD-Score:-4.65|P-value:1.04E-7 ID:SGTC_3021|Compound:9087658|FD-Score:3.19|P-value:1.84E-4 ID:SGTC_3025|Compound:9087895|FD-Score:2.84|P-value:7.64E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.51|P-value:4.45E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.89|P-value:6.98E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.12|P-value:2.42E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.65|P-value:1.02E-7 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.14|P-value:2.26E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.46|P-value:5.61E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.24|P-value:1.48E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.77|P-value:1.27E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.73|P-value:1.52E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.13|P-value:2.32E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.87|P-value:7.62E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:3.45|P-value:5.95E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.99|P-value:4.22E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.80|P-value:8.89E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.26|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.60|P-value:2.88E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.05|P-value:3.29E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.08|P-value:2.97E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.13|P-value:5.11E-20 ID:SGTC_1120|Compound:ficusin|FD-Score:6.20|P-value:2.26E-12 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.86|P-value:8.27E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:9.15|P-value:7.94E-25 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.60|P-value:2.05E-10 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.78|P-value:4.60E-8 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.86|P-value:7.06E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.69|P-value:1.89E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:2.92|P-value:5.53E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.19|P-value:1.42E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.26|P-value:1.37E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-4.50|P-value:2.51E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.32|P-value:7.06E-7 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:2.81E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.44|P-value:3.48E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-3.23|P-value:1.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.29|P-value:1.17E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-2.82|P-value:8.24E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.15|P-value:2.22E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.96|P-value:1.37E-11 ID:SGTC_2030|Compound:5175110|FD-Score:3.43|P-value:6.31E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:1.01E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.70|P-value:1.86E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.95|P-value:5.07E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.04|P-value:3.42E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.74|P-value:1.48E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.97|P-value:4.60E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-2.88|P-value:6.34E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.93|P-value:5.45E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.03|P-value:3.56E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.89|P-value:7.18E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.91|P-value:6.12E-6 ID:SGTC_2831|Compound:7999036|FD-Score:5.99|P-value:1.10E-11 ID:SGTC_2834|Compound:9001755|FD-Score:-4.65|P-value:1.04E-7 ID:SGTC_3021|Compound:9087658|FD-Score:3.19|P-value:1.84E-4 ID:SGTC_3025|Compound:9087895|FD-Score:2.84|P-value:7.64E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.51|P-value:4.45E-5

Top fitness defect scores for YDR411C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1125 tnp00248 9.15 1.3 µM 7.94E-25 1 2.73E-20
2 SGTC_1120 ficusin 6.20 1.8 µM 2.26E-12 3 2.85E-10
3 SGTC_2831 7999036 5.99 19.5 µM 1.10E-11 4 1.03E-9
4 SGTC_1127 asiatic acid 5.60 681.4 nM 2.05E-10 4 1.08E-8
5 SGTC_1376 2910-0861 4.32 41.3 µM 7.06E-7 13 7.76E-6
6 SGTC_2316 5844804 3.97 197.4 µM 4.60E-6 31 3.54E-5
7 SGTC_2644 guaiazulene 3.89 100.0 µM 7.18E-6 5 5.08E-5
8 SGTC_759 3486-0358 3.87 89.3 µM 7.62E-6 22 5.33E-5
9 SGTC_1121 fusaric acid 3.86 630.5 nM 8.27E-6 37 5.70E-5
10 SGTC_562 3772-2733 3.77 112.0 µM 1.27E-5 ERG2 88 8.09E-5
11 SGTC_2284 7945075 3.74 39.2 µM 1.48E-5 mitochondrial processes 31 9.11E-5
12 SGTC_2093 5331342 3.70 194.4 µM 1.86E-5 29 1.10E-4
13 SGTC_1333 1482-0047 3.69 286.0 µM 1.89E-5 23 1.12E-4
14 SGTC_1630 st005209 3.61 31.3 µM 2.81E-5 34 1.54E-4
15 SGTC_928 2764-0428 3.60 58.7 µM 2.88E-5 cell wall 73 1.57E-4
16 SGTC_554 4483-2211 3.46 187.0 µM 5.61E-5 28 2.69E-4
17 SGTC_762 1165-0429 3.45 115.0 µM 5.95E-5 TSC3-RPN4 35 2.82E-4
18 SGTC_2030 5175110 3.43 200.0 µM 6.31E-5 Golgi 41 2.96E-4
19 SGTC_2046 4110841 3.33 106.0 µM 1.01E-4 iron homeostasis 45 4.34E-4
20 SGTC_1372 2752-0194 3.26 270.0 µM 1.37E-4 39 5.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 1.91E-68 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.240 2.42E-45 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.225 1.20E-39 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.220 4.09E-38 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217 5.84E-37 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.209 1.80E-34 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.205 2.94E-33 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.203 2.07E-32 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.201 7.06E-32 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.200 1.19E-31 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.200 1.70E-31 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.197 8.28E-31 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.192 3.04E-29 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.192 3.15E-29 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.187 6.74E-28 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W