YDR417C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR417C / YDR417C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-4.19|P-value:2.77E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.02|P-value:6.61E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.87|P-value:9.55E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.31|P-value:1.67E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.34|P-value:1.44E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.48|P-value:3.30E-13 ID:SGTC_393|Compound:acivicin|FD-Score:-3.46|P-value:4.36E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.40|P-value:5.31E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.50|P-value:3.79E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.65|P-value:2.24E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.74|P-value:1.64E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.26|P-value:8.81E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.53|P-value:3.40E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.50|P-value:3.72E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.53|P-value:6.39E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.51|P-value:3.62E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.61|P-value:2.61E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.64|P-value:3.93E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.25|P-value:2.16E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.35|P-value:1.39E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:6.07|P-value:2.48E-9 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.62|P-value:2.44E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.81|P-value:1.22E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.59|P-value:5.12E-6 ID:SGTC_1723|Compound:st034307|FD-Score:3.70|P-value:1.83E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.08|P-value:4.34E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.28|P-value:7.77E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:1.85E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.69|P-value:1.89E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.58|P-value:2.81E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.42|P-value:4.86E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.51|P-value:3.74E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.40|P-value:1.14E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.09|P-value:4.41E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.80|P-value:1.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.13|P-value:3.39E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.21|P-value:9.95E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.78|P-value:1.41E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.48|P-value:4.19E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-4.54|P-value:6.34E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.64|P-value:2.31E-4 ID:SGTC_3134|Compound:9127454|FD-Score:5.56|P-value:4.21E-8 ID:SGTC_3145|Compound:9085516|FD-Score:3.25|P-value:8.58E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.52|P-value:3.58E-4 ID:SGTC_3347|Compound:9188721|FD-Score:7.97|P-value:8.19E-15 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.19|P-value:2.77E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.02|P-value:6.61E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.87|P-value:9.55E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.31|P-value:1.67E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.34|P-value:1.44E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.48|P-value:3.30E-13 ID:SGTC_393|Compound:acivicin|FD-Score:-3.46|P-value:4.36E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.40|P-value:5.31E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.50|P-value:3.79E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.65|P-value:2.24E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.74|P-value:1.64E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.26|P-value:8.81E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.71|P-value:1.73E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.53|P-value:3.40E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.50|P-value:3.72E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.53|P-value:6.39E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.51|P-value:3.62E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.61|P-value:2.61E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.64|P-value:3.93E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.25|P-value:2.16E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.35|P-value:1.39E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:6.07|P-value:2.48E-9 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.62|P-value:2.44E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.81|P-value:1.22E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.59|P-value:5.12E-6 ID:SGTC_1723|Compound:st034307|FD-Score:3.70|P-value:1.83E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.08|P-value:4.34E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.28|P-value:7.77E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:1.85E-7 ID:SGTC_1870|Compound:st057514|FD-Score:3.69|P-value:1.89E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.58|P-value:2.81E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.42|P-value:4.86E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.51|P-value:3.74E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.40|P-value:1.14E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.09|P-value:4.41E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.80|P-value:1.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.13|P-value:3.39E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.21|P-value:9.95E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.78|P-value:1.41E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.48|P-value:4.19E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-4.54|P-value:6.34E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.64|P-value:2.31E-4 ID:SGTC_3134|Compound:9127454|FD-Score:5.56|P-value:4.21E-8 ID:SGTC_3145|Compound:9085516|FD-Score:3.25|P-value:8.58E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.52|P-value:3.58E-4 ID:SGTC_3347|Compound:9188721|FD-Score:7.97|P-value:8.19E-15

Top fitness defect scores for YDR417C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3347 9188721 7.97 44.7 µM 8.19E-15 3 7.71E-16
2 SGTC_2688 kanamycin b 7.13 96.7 µM 3.39E-12 calcium & mitochondrial duress 103 5.12E-13
3 SGTC_2651 1327-0036 7.09 5.0 µM 4.41E-12 46 6.79E-13
4 SGTC_1363 1636-0063 6.07 10.4 µM 2.48E-9 Golgi 6 6.25E-10
5 SGTC_3134 9127454 5.56 49.5 µM 4.21E-8 4 1.32E-8
6 SGTC_1844 rapamycin 5.28 4.0 nM 1.85E-7 107 6.51E-8
7 SGTC_103 0844-0104 5.02 51.8 µM 6.61E-7 ERAD & cell cycle 102 2.56E-7
8 SGTC_1347 1493-0251 4.64 600.0 nM 3.93E-6 mitochondrial response to ROS 8 1.74E-6
9 SGTC_965 1291-5240 4.53 308.0 µM 6.39E-6 18 2.94E-6
10 SGTC_2565 isoliquiritigenin 4.40 100.0 µM 1.14E-5 24 5.47E-6
11 SGTC_1354 1498-1681 4.35 81.0 µM 1.39E-5 11 6.75E-6
12 SGTC_1352 1496-0991 4.25 99.0 µM 2.16E-5 tubulin folding & SWR complex 26 1.09E-5
13 SGTC_163 1327-0036 3.87 7.5 µM 9.55E-5 110 5.38E-5
14 SGTC_1713 st033146 3.81 12.8 µM 1.22E-4 31 7.03E-5
15 SGTC_2679 rapamycin 3.80 1.0 nM 1.25E-4 155 7.22E-5
16 SGTC_800 3448-7362 3.71 155.0 µM 1.73E-4 translation 184 1.02E-4
17 SGTC_1723 st034307 3.70 2.5 µM 1.83E-4 mitochondrial processes 34 1.08E-4
18 SGTC_1870 st057514 3.69 26.5 µM 1.89E-4 RSC & ERG11 33 1.12E-4
19 SGTC_87 0100-0052 3.63 35.5 µM 2.33E-4 136 1.40E-4
20 SGTC_1364 1653-0028 3.62 37.6 µM 2.44E-4 34 1.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 2.05E-38 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.214 5.58E-36 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.213 7.98E-36 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.211 6.17E-35 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.197 1.11E-30 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.196 2.15E-30 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.190 1.38E-28 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.189 2.37E-28 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.188 4.38E-28 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.187 7.53E-28 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.187 9.84E-28 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.186 1.74E-27 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.184 5.86E-27 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.181 3.18E-26 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.181 3.66E-26 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p