YDR422C / SIP1

Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR422C / SIP1

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:-4.55|P-value:1.28E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.65|P-value:8.51E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.39|P-value:2.48E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.78|P-value:4.57E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.43|P-value:2.61E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.25|P-value:4.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.02|P-value:1.83E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.45|P-value:1.74E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.99|P-value:2.07E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.36|P-value:2.76E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.50|P-value:1.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.18|P-value:8.71E-6 ID:SGTC_1695|Compound:st026914|FD-Score:-3.00|P-value:9.35E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.32|P-value:2.94E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.23|P-value:4.49E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.02|P-value:9.55E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.42|P-value:2.22E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.06|P-value:1.30E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-3.13|P-value:5.85E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.01|P-value:9.20E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.56|P-value:1.25E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.33|P-value:3.66E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.18|P-value:4.90E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.73|P-value:5.65E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-4.77|P-value:4.11E-7 ID:SGTC_2966|Compound:9084041|FD-Score:-3.31|P-value:3.01E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.21|P-value:4.44E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.55|P-value:1.28E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.65|P-value:8.51E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.39|P-value:2.48E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.27|P-value:3.88E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.78|P-value:4.57E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.02|P-value:9.77E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:4.43|P-value:2.61E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:3.25|P-value:4.27E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.02|P-value:1.83E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.45|P-value:1.74E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.99|P-value:2.07E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.36|P-value:2.76E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.50|P-value:1.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.18|P-value:8.71E-6 ID:SGTC_1695|Compound:st026914|FD-Score:-3.00|P-value:9.35E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.32|P-value:2.94E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.23|P-value:4.49E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.02|P-value:9.55E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.42|P-value:2.22E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.06|P-value:1.30E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-3.13|P-value:5.85E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.01|P-value:9.20E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.56|P-value:1.25E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.33|P-value:3.66E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.18|P-value:4.90E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.73|P-value:5.65E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-4.77|P-value:4.11E-7 ID:SGTC_2966|Compound:9084041|FD-Score:-3.31|P-value:3.01E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.21|P-value:4.44E-4

Top fitness defect scores for YDR422C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_143 4032-1194 4.65 15.7 µM 8.51E-7 38 1.63E-6
2 SGTC_869 0564-0080 4.43 44.1 µM 2.61E-6 15 4.69E-6
3 SGTC_1529 apigenin 4.18 74.0 µM 8.71E-6 30 1.46E-5
4 SGTC_955 1216-0110 4.02 33.0 µM 1.83E-5 sphingolipid biosynthesis & PDR1 61 2.96E-5
5 SGTC_1031 k035-0009 3.99 16.0 µM 2.07E-5 29 3.33E-5
6 SGTC_2462 5162487 3.56 171.8 µM 1.25E-4 24 1.82E-4
7 SGTC_1354 1498-1681 3.50 81.0 µM 1.60E-4 34 2.30E-4
8 SGTC_2021 4019055 3.42 173.0 µM 2.22E-4 endomembrane recycling 169 3.14E-4
9 SGTC_188 3229-0966 3.39 278.5 µM 2.48E-4 49 3.49E-4
10 SGTC_1359 1582-0056 3.38 520.0 nM 2.54E-4 36 3.56E-4
11 SGTC_1055 3448-0672 3.36 86.0 µM 2.76E-4 59 3.86E-4
12 SGTC_2564 betulinic acid 3.35 100.0 µM 2.86E-4 57 3.99E-4
13 SGTC_410 α-linolenic acid 3.31 100.0 µM 3.33E-4 excess fatty acid 57 4.60E-4
14 SGTC_356 1634-0012 3.27 32.5 µM 3.88E-4 52 5.33E-4
15 SGTC_916 4466-0038 3.25 42.0 nM 4.27E-4 cell wall 112 5.83E-4
16 SGTC_1735 st034310 3.23 56.8 µM 4.49E-4 Golgi 54 6.12E-4
17 SGTC_180 1486-1293 3.17 102.8 µM 5.66E-4 70 7.62E-4
18 SGTC_1920 st075728 3.02 45.7 µM 9.55E-4 72 0.00125
19 SGTC_610 4215-0184 3.02 155.0 µM 9.77E-4 exosome 45 0.00128
20 SGTC_2102 5377816 2.94 72.8 µM 0.00129 64 0.00166

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.16E-24 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.119 4.60E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.113 4.83E-11 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.110 1.55E-10 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.106 8.00E-10 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.104 1.27E-9 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.103 2.13E-9 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.100 6.82E-9 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.099 8.75E-9 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.098 1.15E-8 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.096 2.38E-8 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.096 2.42E-8 YKL050C YKL050C hom Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
0.093 7.62E-8 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.092 8.14E-8 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 8.64E-8 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C