YDR423C / CAD1

AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR423C / CAD1

Click on Significant Values for Screen Details ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.23|P-value:5.26E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.29|P-value:6.14E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.58|P-value:1.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.89|P-value:5.14E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.38|P-value:6.08E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.57|P-value:2.51E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:6.55|P-value:2.77E-11 ID:SGTC_690|Compound:glyoxal|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.33|P-value:4.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.20|P-value:5.86E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.54|P-value:1.65E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.34|P-value:5.40E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.98|P-value:2.78E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.06|P-value:9.38E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.71|P-value:1.28E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.37|P-value:3.17E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.33|P-value:4.60E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.18|P-value:7.77E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:5.09|P-value:1.86E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-4.18|P-value:1.16E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.76|P-value:8.73E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.77|P-value:6.67E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.49|P-value:2.07E-8 ID:SGTC_1903|Compound:st060211|FD-Score:4.07|P-value:2.50E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.55|P-value:2.00E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.07|P-value:1.86E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.12|P-value:9.58E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.13|P-value:7.31E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.28|P-value:4.35E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.08|P-value:1.80E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.14|P-value:8.78E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.55|P-value:1.57E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.41|P-value:3.46E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.54|P-value:1.65E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.73|P-value:8.55E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.50|P-value:1.88E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.39|P-value:5.82E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.11|P-value:9.75E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.80|P-value:8.27E-7 ID:SGTC_2951|Compound:9072950|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.49|P-value:2.69E-6 ID:SGTC_2963|Compound:9082507|FD-Score:7.36|P-value:8.53E-14 ID:SGTC_2964|Compound:9083345|FD-Score:4.61|P-value:2.07E-6 ID:SGTC_3019|Compound:9081971|FD-Score:3.23|P-value:6.61E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.17|P-value:1.56E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_3207|Compound:9114163|FD-Score:5.94|P-value:1.46E-9 ID:SGTC_3231|Compound:9132313|FD-Score:-3.20|P-value:5.73E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.23|P-value:5.26E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.29|P-value:6.14E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.58|P-value:1.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.89|P-value:5.14E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:4.38|P-value:6.08E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.57|P-value:2.51E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:6.55|P-value:2.77E-11 ID:SGTC_690|Compound:glyoxal|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.33|P-value:4.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.37|P-value:3.98E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.20|P-value:5.86E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.54|P-value:1.65E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.34|P-value:5.40E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.98|P-value:2.78E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.06|P-value:9.38E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.71|P-value:1.28E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.37|P-value:3.17E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.33|P-value:4.60E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.18|P-value:7.77E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:5.09|P-value:1.86E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-4.18|P-value:1.16E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.76|P-value:8.73E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.77|P-value:6.67E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.49|P-value:2.07E-8 ID:SGTC_1903|Compound:st060211|FD-Score:4.07|P-value:2.50E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-4.55|P-value:2.00E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.07|P-value:1.86E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.12|P-value:9.58E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.13|P-value:7.31E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.28|P-value:4.35E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.08|P-value:1.80E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.66|P-value:1.04E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.14|P-value:8.78E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.55|P-value:1.57E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.41|P-value:3.46E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.54|P-value:1.65E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.73|P-value:8.55E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.50|P-value:1.88E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.39|P-value:5.82E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.11|P-value:9.75E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.80|P-value:8.27E-7 ID:SGTC_2951|Compound:9072950|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.49|P-value:2.69E-6 ID:SGTC_2963|Compound:9082507|FD-Score:7.36|P-value:8.53E-14 ID:SGTC_2964|Compound:9083345|FD-Score:4.61|P-value:2.07E-6 ID:SGTC_3019|Compound:9081971|FD-Score:3.23|P-value:6.61E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.17|P-value:1.56E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.37|P-value:4.01E-4 ID:SGTC_3207|Compound:9114163|FD-Score:5.94|P-value:1.46E-9 ID:SGTC_3231|Compound:9132313|FD-Score:-3.20|P-value:5.73E-4

Top fitness defect scores for YDR423C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2963 9082507 7.36 9.0 µM 8.53E-14 2 9.12E-14
2 SGTC_669 0108-0021 6.55 26.2 µM 2.77E-11 fatty acid desaturase (OLE1) 22 2.85E-11
3 SGTC_3207 9114163 5.94 49.5 µM 1.46E-9 7 1.47E-9
4 SGTC_1889 st059080 5.49 5.2 µM 2.07E-8 1 2.05E-8
5 SGTC_273 hydroxyurea 5.29 18.1 mM 6.14E-8 heme biosynthesis & mitochondrial translocase 13 6.05E-8
6 SGTC_1507 4075-3230 5.09 155.0 µM 1.86E-7 7 1.83E-7
7 SGTC_2876 9059903 4.80 26.0 µM 8.27E-7 3 8.05E-7
8 SGTC_1212 0520-0165 4.71 585.0 µM 1.28E-6 13 1.24E-6
9 SGTC_2964 9083345 4.61 53.4 µM 2.07E-6 12 2.01E-6
10 SGTC_605 1315-0399 4.57 119.0 µM 2.51E-6 Golgi 10 2.43E-6
11 SGTC_2703 st077852 4.39 53.4 µM 5.82E-6 12 5.62E-6
12 SGTC_597 k018-0003 4.38 82.8 µM 6.08E-6 RNA pol III & RNase P/MRP 7 5.87E-6
13 SGTC_3072 9116419 4.17 49.5 µM 1.56E-5 ERG2 12 1.50E-5
14 SGTC_3056 9094900 4.16 49.5 µM 1.67E-5 18 1.60E-5
15 SGTC_1903 st060211 4.07 78.3 µM 2.50E-5 24 2.40E-5
16 SGTC_457 grayanotoxin iii 3.89 135.0 µM 5.14E-5 70 4.92E-5
17 SGTC_1525 8-methoxypsoralen 3.76 92.5 µM 8.73E-5 DNA damage response 36 8.35E-5
18 SGTC_604 1000-0114 3.56 314.0 µM 1.92E-4 36 1.83E-4
19 SGTC_2564 betulinic acid 3.41 100.0 µM 3.46E-4 52 3.30E-4
20 SGTC_690 glyoxal 3.37 20.3 µM 3.93E-4 121 3.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.50E-21 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.141 2.18E-16 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.126 2.15E-13 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.123 7.80E-13 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.106 7.19E-10 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.104 1.29E-9 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.100 7.05E-9 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.095 3.42E-8 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.094 4.90E-8 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.094 5.54E-8 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.093 5.86E-8 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.093 6.01E-8 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.093 7.20E-8 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.091 1.10E-7 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.091 1.28E-7 YOR356W CIR2 hom Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response