HIPHOP chemogenomics database

YDR425W / SNX41

Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR425W / SNX41

Click on Significant Values for Screen Details

Top fitness defect scores for YDR425W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1916	st067606	4.97	49.2 µM	3.86E-8		17	3.31E-7
2	SGTC_344	k064-0035	4.87	6.4 µM	6.96E-8	60S ribosome export	13	5.51E-7
3	SGTC_1913	st060213	4.18	96.1 µM	3.15E-6		25	1.49E-5
4	SGTC_1043	0916-0009	4.07	19.3 µM	5.24E-6		19	2.31E-5
5	SGTC_1320	1313-0481	3.79	95.3 µM	2.04E-5		27	7.48E-5
6	SGTC_987	1497-1013	3.76	404.0 µM	2.35E-5		16	8.44E-5
7	SGTC_604	1000-0114	3.74	314.0 µM	2.64E-5		28	9.33E-5
8	SGTC_2354	9060492	3.57	162.0 µM	5.46E-5		29	1.75E-4
9	SGTC_59	0330-0160	3.53	1.3 µM	6.73E-5		143	2.10E-4
10	SGTC_143	4032-1194	3.46	15.7 µM	8.86E-5		93	2.66E-4
11	SGTC_70	0141-0289	3.44	43.3 µM	9.77E-5	mitochondrial stress	221	2.90E-4
12	SGTC_2439	5492030	3.42	7.2 µM	1.09E-4		24	3.18E-4
13	SGTC_259	usnic acid	3.37	108.9 µM	1.31E-4		35	3.74E-4
14	SGTC_397	arbidol	3.31	50.0 µM	1.71E-4	cell wall	41	4.72E-4
15	SGTC_245	methotrexate	3.27	289.6 µM	1.96E-4		68	5.29E-4
16	SGTC_1872	amphotericin b	2.91	148.0 nM	8.20E-4	RNA pol III & RNase P/MRP	69	0.00183
17	SGTC_1618	st003135	2.89	44.5 µM	8.74E-4		53	0.00194
18	SGTC_247	mechlorethamine	2.87	29.7 µM	9.43E-4	DNA damage response	49	0.00207
19	SGTC_2426	5582046	2.83	32.2 µM	0.00109		81	0.00234
20	SGTC_239	5hr heat shock (37°C) + mitomycin C	2.82	819.4 µM	0.00112	heat shock/prefoldin	86	0.00241

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.129	5.74E-14	YDR416W	SYF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.115	2.15E-11	YDR414C	ERD1	hom	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.112	7.02E-11	YNL257C	SIP3	hom	Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.096	2.86E-8	YNL284C	MRPL10	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.094	5.47E-8	YCL009C	ILV6	hom	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.092	9.56E-8	YDR509W_d	YDR509W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091	1.30E-7	YLR436C	ECM30	hom	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.090	1.75E-7	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089	2.24E-7	YMR326C_d	YMR326C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.089	2.70E-7	YHR103W	SBE22	hom	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.087	4.41E-7	YGL096W	TOS8	hom	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.086	5.64E-7	YDL096C_d	OPI6_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.086	5.97E-7	YHR155W	YSP1	hom	Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.085	8.78E-7	YBR068C	BAP2	hom	High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.082	2.14E-6	YOR074C	CDC21	het	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S