YDR442W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR442W / YDR442W

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:-3.51|P-value:9.01E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.48|P-value:4.02E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.61|P-value:2.44E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.39|P-value:5.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.85|P-value:1.25E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.06|P-value:1.76E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.49|P-value:3.87E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.83|P-value:3.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.74|P-value:1.25E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.61|P-value:6.56E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.35|P-value:6.38E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.51|P-value:3.52E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.58|P-value:8.22E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.57|P-value:8.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.04|P-value:1.64E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.56|P-value:8.68E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.52|P-value:8.76E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.53|P-value:9.58E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.59|P-value:7.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.29|P-value:7.95E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.91|P-value:9.25E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.54|P-value:9.16E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.33|P-value:1.32E-6 ID:SGTC_1959|Compound:st077091|FD-Score:4.63|P-value:2.28E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.50|P-value:9.30E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.62|P-value:6.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.62|P-value:7.31E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.53|P-value:3.27E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-6.00|P-value:5.08E-8 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.37|P-value:5.95E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.66|P-value:6.34E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.17|P-value:2.63E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.64|P-value:2.15E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.07|P-value:1.70E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.89|P-value:3.03E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.15|P-value:1.30E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.83|P-value:3.26E-4 ID:SGTC_3132|Compound:9126706|FD-Score:5.97|P-value:7.09E-8 ID:SGTC_3138|Compound:9097216|FD-Score:4.36|P-value:6.07E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.05|P-value:1.59E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.66|P-value:6.33E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.61|P-value:6.58E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.88|P-value:2.78E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.51|P-value:9.01E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.48|P-value:4.02E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.61|P-value:2.44E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.39|P-value:5.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.85|P-value:1.25E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.06|P-value:1.76E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.49|P-value:3.87E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.83|P-value:3.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.74|P-value:1.25E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.61|P-value:6.56E-4 ID:SGTC_512|Compound:prima-1|FD-Score:4.35|P-value:6.38E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.51|P-value:3.52E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.58|P-value:8.22E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.57|P-value:8.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.04|P-value:1.64E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.56|P-value:8.68E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.52|P-value:8.76E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.53|P-value:9.58E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.59|P-value:7.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.29|P-value:7.95E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.91|P-value:9.25E-8 ID:SGTC_1675|Compound:st018485|FD-Score:3.54|P-value:9.16E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.33|P-value:1.32E-6 ID:SGTC_1959|Compound:st077091|FD-Score:4.63|P-value:2.28E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.50|P-value:9.30E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.62|P-value:6.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.62|P-value:7.31E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.53|P-value:3.27E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-6.00|P-value:5.08E-8 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.37|P-value:5.95E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.66|P-value:6.34E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.17|P-value:2.63E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.64|P-value:2.15E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.07|P-value:1.70E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.89|P-value:3.03E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.15|P-value:1.30E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.83|P-value:3.26E-4 ID:SGTC_3132|Compound:9126706|FD-Score:5.97|P-value:7.09E-8 ID:SGTC_3138|Compound:9097216|FD-Score:4.36|P-value:6.07E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.05|P-value:1.59E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.66|P-value:6.33E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.61|P-value:6.58E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.88|P-value:2.78E-4

Top fitness defect scores for YDR442W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3132 9126706 5.97 49.5 µM 7.09E-8 5 1.21E-9
2 SGTC_1597 7-benzyloxygramine 5.91 47.5 µM 9.25E-8 calcium & mitochondrial duress 51 1.70E-9
3 SGTC_241 5hr heat shock (37°C) + cantharidin 5.85 155.4 µM 1.25E-7 cell wall signaling 33 2.50E-9
4 SGTC_1712 st032288 5.33 53.4 µM 1.32E-6 calcium & mitochondrial duress 99 5.01E-8
5 SGTC_2633 5,7-dihydroxyisoflavone 5.17 100.0 µM 2.63E-6 15 1.20E-7
6 SGTC_2636 apigenin dimethyl ether 4.64 100.0 µM 2.15E-5 24 1.72E-6
7 SGTC_1959 st077091 4.63 55.8 µM 2.28E-5 RPP1 & pyrimidine depletion 29 1.86E-6
8 SGTC_187 1488-2104 4.61 32.7 µM 2.44E-5 calcium & mitochondrial duress 26 2.03E-6
9 SGTC_2291 7917025 4.53 104.3 µM 3.27E-5 iron homeostasis 37 2.94E-6
10 SGTC_515 4092-1064 4.51 102.0 µM 3.52E-5 plasma membrane duress 45 3.23E-6
11 SGTC_268 camptothecin 4.49 39.6 µM 3.87E-5 DNA damage response 55 3.63E-6
12 SGTC_149 3970-0822 4.48 46.1 µM 4.02E-5 tubulin folding & SWR complex 66 3.81E-6
13 SGTC_227 fluconazole 4.39 33.5 µM 5.43E-5 azole & statin 67 5.58E-6
14 SGTC_2614 arthonioic acid 4.37 13.4 µM 5.95E-5 15 6.27E-6
15 SGTC_3138 9097216 4.36 49.5 µM 6.07E-5 10 6.43E-6
16 SGTC_512 prima-1 4.35 270.0 µM 6.38E-5 DNA intercalators 19 6.86E-6
17 SGTC_1572 epiandrosterone 4.29 68.9 µM 7.95E-5 23 9.06E-6
18 SGTC_3031 9088762 4.15 49.5 µM 1.30E-4 14 1.69E-5
19 SGTC_2688 kanamycin b 4.07 96.7 µM 1.70E-4 calcium & mitochondrial duress 352 2.37E-5
20 SGTC_248 streptozotocin 4.06 5.2 mM 1.76E-4 DNA damage response 25 2.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 6.58E-48 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.221 2.94E-38 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.210 7.07E-35 YNL025C SSN8 hom Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
0.209 2.40E-34 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.200 1.19E-31 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.188 3.94E-28 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.187 9.45E-28 YPL042C SSN3 hom Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
0.166 3.71E-22 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.159 2.58E-20 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.152 8.30E-19 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.151 1.57E-18 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.143 1.03E-16 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.141 2.41E-16 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.136 2.10E-15 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.136 3.13E-15 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin