YDR449C / UTP6

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR449C / UTP6

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.10|P-value:1.30E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:5.98|P-value:4.24E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:4.11|P-value:3.51E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.35|P-value:8.43E-8 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.62|P-value:8.37E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-5.23|P-value:9.97E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:4.26|P-value:2.22E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.86|P-value:7.16E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.74|P-value:4.59E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:-5.05|P-value:1.94E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.24|P-value:2.30E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.78|P-value:9.58E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:4.00|P-value:4.73E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.87|P-value:2.91E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.24|P-value:1.40E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:4.19|P-value:2.68E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.87|P-value:6.90E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:6.41|P-value:6.46E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:5.70|P-value:1.34E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.13|P-value:3.28E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-4.16|P-value:3.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-8.38|P-value:3.75E-12 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.44|P-value:1.47E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.80|P-value:8.39E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-5.13|P-value:1.44E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.81|P-value:8.32E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.81|P-value:9.52E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.04|P-value:5.03E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.04|P-value:4.27E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.84|P-value:8.97E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-6.80|P-value:1.38E-8 ID:SGTC_2038|Compound:4100038|FD-Score:-8.37|P-value:3.84E-12 ID:SGTC_2046|Compound:4110841|FD-Score:-4.92|P-value:3.07E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-4.29|P-value:2.39E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.22|P-value:1.02E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.93|P-value:1.06E-13 ID:SGTC_2306|Compound:7482397|FD-Score:3.76|P-value:9.48E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.46|P-value:1.17E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.44|P-value:1.49E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-6.47|P-value:6.49E-8 ID:SGTC_2350|Compound:9023895|FD-Score:-4.28|P-value:2.46E-4 ID:SGTC_2358|Compound:9037157|FD-Score:5.58|P-value:2.12E-6 ID:SGTC_2411|Compound:st077133|FD-Score:-5.02|P-value:2.15E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-3.81|P-value:9.59E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-4.58|P-value:9.52E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.97|P-value:5.27E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.78|P-value:9.06E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.30|P-value:2.28E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.58|P-value:7.80E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.23|P-value:2.44E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.92|P-value:7.07E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.42|P-value:1.59E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.61|P-value:8.60E-5 ID:SGTC_3000|Compound:9075062|FD-Score:-5.02|P-value:2.10E-5 ID:SGTC_3055|Compound:9094636|FD-Score:5.20|P-value:8.98E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.93|P-value:6.84E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.73|P-value:4.74E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-4.04|P-value:5.01E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.54|P-value:1.07E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.84|P-value:9.23E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-4.32|P-value:2.19E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:5.10|P-value:1.30E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:5.98|P-value:4.24E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:4.11|P-value:3.51E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.35|P-value:8.43E-8 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.62|P-value:8.37E-5 ID:SGTC_252|Compound:miconazole|FD-Score:-5.23|P-value:9.97E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:4.26|P-value:2.22E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.86|P-value:7.16E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:4.74|P-value:4.59E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:-5.05|P-value:1.94E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.24|P-value:2.30E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.78|P-value:9.58E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:4.00|P-value:4.73E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.87|P-value:2.91E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.24|P-value:1.40E-7 ID:SGTC_851|Compound:0394-0702|FD-Score:4.19|P-value:2.68E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.87|P-value:6.90E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:6.41|P-value:6.46E-8 ID:SGTC_977|Compound:1348-1378|FD-Score:5.70|P-value:1.34E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.13|P-value:3.28E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-4.16|P-value:3.52E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-8.38|P-value:3.75E-12 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.44|P-value:1.47E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.80|P-value:8.39E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-5.13|P-value:1.44E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.81|P-value:8.32E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.81|P-value:9.52E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.04|P-value:5.03E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.04|P-value:4.27E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-3.84|P-value:8.97E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-6.80|P-value:1.38E-8 ID:SGTC_2038|Compound:4100038|FD-Score:-8.37|P-value:3.84E-12 ID:SGTC_2046|Compound:4110841|FD-Score:-4.92|P-value:3.07E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-4.29|P-value:2.39E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.22|P-value:1.02E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.93|P-value:1.06E-13 ID:SGTC_2306|Compound:7482397|FD-Score:3.76|P-value:9.48E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.46|P-value:1.17E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.44|P-value:1.49E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-6.47|P-value:6.49E-8 ID:SGTC_2350|Compound:9023895|FD-Score:-4.28|P-value:2.46E-4 ID:SGTC_2358|Compound:9037157|FD-Score:5.58|P-value:2.12E-6 ID:SGTC_2411|Compound:st077133|FD-Score:-5.02|P-value:2.15E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-3.81|P-value:9.59E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-4.58|P-value:9.52E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.97|P-value:5.27E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.78|P-value:9.06E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.30|P-value:2.28E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.58|P-value:7.80E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.23|P-value:2.44E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.92|P-value:7.07E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.42|P-value:1.59E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-4.61|P-value:8.60E-5 ID:SGTC_3000|Compound:9075062|FD-Score:-5.02|P-value:2.10E-5 ID:SGTC_3055|Compound:9094636|FD-Score:5.20|P-value:8.98E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-3.93|P-value:6.84E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.73|P-value:4.74E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-4.04|P-value:5.01E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.54|P-value:1.07E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.84|P-value:9.23E-7 ID:SGTC_3296|Compound:9122258|FD-Score:-4.32|P-value:2.19E-4

Top fitness defect scores for YDR449C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2233 sulbentine 8.93 40.4 µM 1.06E-13 11 2.22E-19 0.23
2 SGTC_971 1315-0384 6.41 26.7 µM 6.46E-8 cell wall signaling 1 7.21E-11 0.94
3 SGTC_138 0850-0259 6.35 40.9 µM 8.43E-8 cell wall 29 1.06E-10 0.04
4 SGTC_800 3448-7362 6.24 155.0 µM 1.40E-7 translation 21 2.24E-10 0.17
5 SGTC_22 0964-0034 5.98 14.5 µM 4.24E-7 unfolded protein response 18 1.13E-9 0.39
6 SGTC_673 1082-0474 5.78 110.0 µM 9.58E-7 RSC complex & mRNA processing 29 3.74E-9 0.11
7 SGTC_977 1348-1378 5.70 135.0 µM 1.34E-6 2 6.11E-9 0.65
8 SGTC_2358 9037157 5.58 4.0 µM 2.12E-6 5 1.19E-8 0.38
9 SGTC_3055 9094636 5.20 49.5 µM 8.98E-6 2 9.82E-8 0.26
10 SGTC_1 0258-0098 5.10 57.4 µM 1.30E-5 heme biosynthesis & mitochondrial translocase 12 1.68E-7 0.52
11 SGTC_988 1497-1057 5.06 103.0 µM 1.53E-5 2 2.14E-7 0.77
12 SGTC_691 1548-0686 4.87 185.0 µM 2.91E-5 5 5.44E-7 0.36
13 SGTC_617 3770-0098 4.74 35.0 µM 4.59E-5 exosome 19 1.06E-6 0.02
14 SGTC_3128 9127691 4.73 49.5 µM 4.74E-5 1 1.11E-6 1.04
15 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.58 100.0 µM 7.80E-5 5 2.28E-6 9.45E-4
16 SGTC_2307 7538926 4.46 6.3 µM 1.17E-4 18 4.10E-6 0.15
17 SGTC_288 1315-0019 4.26 35.1 µM 2.22E-4 RSC & ERG11 17 1.04E-5 0.08
18 SGTC_625 k213-0058 4.24 121.0 µM 2.30E-4 translation 15 1.10E-5 0.09
19 SGTC_2617 dihydrotanshinone i 4.23 20.8 µM 2.44E-4 copper-dependent oxidative stress 18 1.19E-5 0.01
20 SGTC_851 0394-0702 4.19 453.0 µM 2.68E-4 mitochondrial processes 18 1.37E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.68E-40 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.226 3.64E-40 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.202 4.65E-32 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.177 6.27E-25 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.171 1.95E-23 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.161 6.89E-21 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.150 2.00E-18 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.150 2.80E-18 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.148 8.36E-18 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.138 1.02E-15 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.136 2.43E-15 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.128 8.71E-14 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
0.126 2.85E-13 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.119 3.98E-12 YLR075W RPL10 het Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
0.116 1.93E-11 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity