YDR453C / TSA2

Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR453C / TSA2

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.83|P-value:1.30E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.00|P-value:4.85E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:2.84|P-value:9.67E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.92|P-value:7.06E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:2.85|P-value:9.40E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.81|P-value:1.55E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:-2.97|P-value:5.46E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.86|P-value:8.28E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:8.74|P-value:5.77E-22 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.87|P-value:4.42E-8 ID:SGTC_781|Compound:4335-2806|FD-Score:4.88|P-value:4.64E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:-5.43|P-value:1.31E-9 ID:SGTC_790|Compound:1575-0012|FD-Score:4.30|P-value:1.31E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.67|P-value:3.01E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:3.58|P-value:4.54E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:2.90|P-value:7.74E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.85|P-value:9.27E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:2.86|P-value:8.77E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.54|P-value:3.36E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.92|P-value:7.01E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.46|P-value:7.25E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.52|P-value:5.91E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.94|P-value:6.63E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.47|P-value:5.22E-7 ID:SGTC_2021|Compound:4019055|FD-Score:2.88|P-value:8.36E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-2.86|P-value:8.34E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.02|P-value:4.92E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.13|P-value:3.19E-6 ID:SGTC_2154|Compound:5570129|FD-Score:-2.83|P-value:9.24E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_2178|Compound:5812956|FD-Score:2.88|P-value:8.27E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-2.97|P-value:5.51E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-2.85|P-value:8.81E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.46|P-value:7.19E-5 ID:SGTC_2423|Compound:st077119|FD-Score:4.35|P-value:9.90E-7 ID:SGTC_2427|Compound:5545055|FD-Score:-3.40|P-value:9.26E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.08|P-value:3.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.25|P-value:1.91E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.89|P-value:7.94E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-2.91|P-value:6.84E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.01|P-value:4.99E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.06|P-value:4.19E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.37|P-value:1.05E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.39|P-value:1.04E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.12|P-value:3.28E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.16|P-value:2.52E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.12|P-value:3.28E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.84|P-value:9.01E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-4.32|P-value:1.08E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.50|P-value:6.18E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.91|P-value:9.44E-6 ID:SGTC_3202|Compound:9113761|FD-Score:6.48|P-value:6.71E-13 ID:SGTC_3304|Compound:9125678|FD-Score:-3.23|P-value:1.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.12|P-value:3.30E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.83|P-value:1.30E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.00|P-value:4.85E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:2.84|P-value:9.67E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.92|P-value:7.06E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:2.85|P-value:9.40E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.81|P-value:1.55E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:-2.97|P-value:5.46E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.86|P-value:8.28E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:8.74|P-value:5.77E-22 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.87|P-value:4.42E-8 ID:SGTC_781|Compound:4335-2806|FD-Score:4.88|P-value:4.64E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:-5.43|P-value:1.31E-9 ID:SGTC_790|Compound:1575-0012|FD-Score:4.30|P-value:1.31E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.67|P-value:3.01E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:3.58|P-value:4.54E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:2.90|P-value:7.74E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.85|P-value:9.27E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:2.86|P-value:8.77E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.54|P-value:3.36E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.92|P-value:7.01E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.46|P-value:7.25E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.52|P-value:5.91E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.94|P-value:6.63E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.47|P-value:5.22E-7 ID:SGTC_2021|Compound:4019055|FD-Score:2.88|P-value:8.36E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-2.86|P-value:8.34E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.02|P-value:4.92E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.13|P-value:3.19E-6 ID:SGTC_2154|Compound:5570129|FD-Score:-2.83|P-value:9.24E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.38|P-value:1.09E-4 ID:SGTC_2178|Compound:5812956|FD-Score:2.88|P-value:8.27E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-2.97|P-value:5.51E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-2.85|P-value:8.81E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.46|P-value:7.19E-5 ID:SGTC_2423|Compound:st077119|FD-Score:4.35|P-value:9.90E-7 ID:SGTC_2427|Compound:5545055|FD-Score:-3.40|P-value:9.26E-5 ID:SGTC_2461|Compound:5755302|FD-Score:-3.08|P-value:3.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.25|P-value:1.91E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.89|P-value:7.94E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-2.91|P-value:6.84E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.01|P-value:4.99E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.06|P-value:4.19E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.37|P-value:1.05E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.39|P-value:1.04E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.12|P-value:3.28E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.16|P-value:2.52E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.12|P-value:3.28E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.84|P-value:9.01E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-4.32|P-value:1.08E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.50|P-value:6.18E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.91|P-value:9.44E-6 ID:SGTC_3202|Compound:9113761|FD-Score:6.48|P-value:6.71E-13 ID:SGTC_3304|Compound:9125678|FD-Score:-3.23|P-value:1.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.12|P-value:3.30E-6

Top fitness defect scores for YDR453C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_774 k060-0086 8.74 136.0 µM 5.77E-22 3 1.20E-18
2 SGTC_3202 9113761 6.48 49.5 µM 6.71E-13 7 4.59E-11
3 SGTC_781 4335-2806 4.88 94.4 µM 4.64E-8 9 5.22E-7
4 SGTC_1230 0170-0365 4.54 3.8 µM 3.36E-7 endomembrane recycling 44 2.76E-6
5 SGTC_2014 4013930 4.47 200.0 µM 5.22E-7 17 3.99E-6
6 SGTC_2423 st077119 4.35 87.2 µM 9.90E-7 8 6.83E-6
7 SGTC_790 1575-0012 4.30 79.1 µM 1.31E-6 TSC3-RPN4 19 8.66E-6
8 SGTC_2057 5236571 4.13 38.3 µM 3.19E-6 RPP1 & pyrimidine depletion 26 1.83E-5
9 SGTC_2954 9074818 4.12 52.7 µM 3.28E-6 34 1.87E-5
10 SGTC_3334 9142812 4.12 21.9 µM 3.30E-6 26 1.88E-5
11 SGTC_3142 9086498 3.91 49.5 µM 9.44E-6 iron homeostasis 37 4.56E-5
12 SGTC_524 r073-0010 3.81 27.8 µM 1.55E-5 55 6.90E-5
13 SGTC_873 0591-4978 3.67 488.0 µM 3.01E-5 23 1.21E-4
14 SGTC_879 0831-1030 3.58 162.0 µM 4.54E-5 62 1.71E-4
15 SGTC_1829 berberine 3.52 14.4 µM 5.91E-5 60S ribosome export 30 2.14E-4
16 SGTC_2859 9028643 3.39 45.5 µM 1.04E-4 30 3.44E-4
17 SGTC_2164 5685496 3.38 200.0 µM 1.09E-4 35 3.57E-4
18 SGTC_1719 st032227 3.36 49.2 µM 1.18E-4 44 3.84E-4
19 SGTC_2467 5474540 3.25 200.0 µM 1.91E-4 45 5.74E-4
20 SGTC_1277 0873-0036 3.22 22.0 µM 2.15E-4 PDR1 50 6.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 8.76E-18 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.144 4.18E-17 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.127 1.80E-13 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.126 2.99E-13 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.113 4.51E-11 YLR461W PAU4 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.113 5.09E-11 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.108 3.90E-10 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.094 4.37E-8 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.094 4.39E-8 YOL030W GAS5 hom 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
0.094 4.58E-8 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.093 5.85E-8 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.093 7.74E-8 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.091 1.17E-7 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.088 3.39E-7 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.088 3.89E-7 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein