YDR456W / NHX1

Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR456W / NHX1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.47|P-value:2.94E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.67|P-value:8.24E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.54|P-value:2.01E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:3.26|P-value:6.30E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.32|P-value:4.67E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.26|P-value:5.71E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.31|P-value:9.64E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:27.60|P-value:1.56E-165 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.30|P-value:3.71E-59 ID:SGTC_232|Compound:clozapine|FD-Score:19.50|P-value:1.10E-83 ID:SGTC_245|Compound:methotrexate|FD-Score:4.15|P-value:1.99E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.98|P-value:3.96E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.30|P-value:1.39E-34 ID:SGTC_263|Compound:alizarin|FD-Score:8.72|P-value:2.40E-18 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:3.77E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.86|P-value:6.61E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:11.90|P-value:2.32E-32 ID:SGTC_313|Compound:3474-0040|FD-Score:4.46|P-value:4.82E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.04|P-value:2.84E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:6.97|P-value:2.33E-12 ID:SGTC_352|Compound:k048-0007|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.61|P-value:2.64E-11 ID:SGTC_398|Compound:bronopol|FD-Score:6.66|P-value:1.96E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.47|P-value:7.00E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.27|P-value:5.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.35|P-value:8.01E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:8.46|P-value:2.35E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:14.70|P-value:1.27E-48 ID:SGTC_605|Compound:1315-0399|FD-Score:4.63|P-value:2.24E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:9.65|P-value:4.81E-22 ID:SGTC_642|Compound:0335-0876|FD-Score:4.23|P-value:1.38E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:3.33E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:4.78|P-value:1.05E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:4.40|P-value:6.38E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.40|P-value:3.45E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.60|P-value:1.81E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.65|P-value:1.49E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:7.23|P-value:3.58E-13 ID:SGTC_878|Compound:0828-0289|FD-Score:6.07|P-value:8.55E-10 ID:SGTC_888|Compound:0916-0002|FD-Score:14.60|P-value:1.21E-47 ID:SGTC_900|Compound:1112-0045|FD-Score:5.50|P-value:2.52E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:6.07|P-value:8.58E-10 ID:SGTC_993|Compound:3909-8757|FD-Score:5.04|P-value:2.89E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.97|P-value:4.23E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:8.15|P-value:3.10E-16 ID:SGTC_1081|Compound:sertraline|FD-Score:8.97|P-value:2.57E-19 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.20|P-value:2.49E-24 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.48|P-value:2.86E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.17|P-value:5.43E-13 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.35|P-value:4.50E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.44|P-value:3.03E-4 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:1.06E-6 ID:SGTC_1608|Compound:st001473|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.26|P-value:9.00E-8 ID:SGTC_1658|Compound:st012944|FD-Score:5.90|P-value:2.40E-9 ID:SGTC_1672|Compound:st016598|FD-Score:4.07|P-value:2.74E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.94|P-value:4.81E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.15|P-value:1.92E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.29|P-value:2.33E-13 ID:SGTC_1781|Compound:st038725|FD-Score:24.60|P-value:4.13E-132 ID:SGTC_1786|Compound:berberine|FD-Score:-3.32|P-value:4.68E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.40|P-value:8.34E-41 ID:SGTC_1803|Compound:st050068|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.25|P-value:2.77E-10 ID:SGTC_2006|Compound:4011487|FD-Score:10.90|P-value:1.35E-27 ID:SGTC_2007|Compound:4011539|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.29|P-value:5.05E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.89|P-value:5.92E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.20|P-value:7.70E-4 ID:SGTC_2359|Compound:9039622|FD-Score:6.02|P-value:1.17E-9 ID:SGTC_2374|Compound:9071832|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_2472|Compound:5377652|FD-Score:10.40|P-value:3.87E-25 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.78|P-value:5.95E-15 ID:SGTC_2586|Compound:curcumin|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.73|P-value:1.37E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:5.93|P-value:2.07E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.85|P-value:5.36E-12 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.62|P-value:2.32E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.77|P-value:5.35E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:15.80|P-value:5.22E-56 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.30|P-value:5.93E-59 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.29|P-value:5.07E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.14|P-value:2.02E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.25|P-value:6.46E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.42|P-value:3.17E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.23|P-value:1.10E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.82|P-value:7.60E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.43|P-value:3.45E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.88|P-value:2.78E-9 ID:SGTC_3152|Compound:9099253|FD-Score:12.20|P-value:2.83E-34 ID:SGTC_3166|Compound:9102297|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_3218|Compound:9131285|FD-Score:8.25|P-value:1.32E-16 ID:SGTC_3242|Compound:9133940|FD-Score:-3.18|P-value:7.55E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.75|P-value:9.00E-5 ID:SGTC_3286|Compound:9117135|FD-Score:-3.10|P-value:9.75E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.47|P-value:2.94E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.67|P-value:8.24E-9 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.54|P-value:2.01E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:3.26|P-value:6.30E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.32|P-value:4.67E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.26|P-value:5.71E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.31|P-value:9.64E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:27.60|P-value:1.56E-165 ID:SGTC_221|Compound:trifluoperazine|FD-Score:16.30|P-value:3.71E-59 ID:SGTC_232|Compound:clozapine|FD-Score:19.50|P-value:1.10E-83 ID:SGTC_245|Compound:methotrexate|FD-Score:4.15|P-value:1.99E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.98|P-value:3.96E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:12.30|P-value:1.39E-34 ID:SGTC_263|Compound:alizarin|FD-Score:8.72|P-value:2.40E-18 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:3.77E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.86|P-value:6.61E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:11.90|P-value:2.32E-32 ID:SGTC_313|Compound:3474-0040|FD-Score:4.46|P-value:4.82E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.04|P-value:2.84E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:6.97|P-value:2.33E-12 ID:SGTC_352|Compound:k048-0007|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.61|P-value:2.64E-11 ID:SGTC_398|Compound:bronopol|FD-Score:6.66|P-value:1.96E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.47|P-value:7.00E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.27|P-value:5.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.35|P-value:8.01E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:8.46|P-value:2.35E-17 ID:SGTC_568|Compound:1193-0097|FD-Score:14.70|P-value:1.27E-48 ID:SGTC_605|Compound:1315-0399|FD-Score:4.63|P-value:2.24E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:9.65|P-value:4.81E-22 ID:SGTC_642|Compound:0335-0876|FD-Score:4.23|P-value:1.38E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:3.33E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:4.78|P-value:1.05E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:4.40|P-value:6.38E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.40|P-value:3.45E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.60|P-value:1.81E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.65|P-value:1.49E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:7.23|P-value:3.58E-13 ID:SGTC_878|Compound:0828-0289|FD-Score:6.07|P-value:8.55E-10 ID:SGTC_888|Compound:0916-0002|FD-Score:14.60|P-value:1.21E-47 ID:SGTC_900|Compound:1112-0045|FD-Score:5.50|P-value:2.52E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:6.07|P-value:8.58E-10 ID:SGTC_993|Compound:3909-8757|FD-Score:5.04|P-value:2.89E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.97|P-value:4.23E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:8.15|P-value:3.10E-16 ID:SGTC_1081|Compound:sertraline|FD-Score:8.97|P-value:2.57E-19 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:10.20|P-value:2.49E-24 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.48|P-value:2.86E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.17|P-value:5.43E-13 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.35|P-value:4.50E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.44|P-value:3.03E-4 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:1.06E-6 ID:SGTC_1608|Compound:st001473|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.26|P-value:9.00E-8 ID:SGTC_1658|Compound:st012944|FD-Score:5.90|P-value:2.40E-9 ID:SGTC_1672|Compound:st016598|FD-Score:4.07|P-value:2.74E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.94|P-value:4.81E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.15|P-value:1.92E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.29|P-value:2.33E-13 ID:SGTC_1781|Compound:st038725|FD-Score:24.60|P-value:4.13E-132 ID:SGTC_1786|Compound:berberine|FD-Score:-3.32|P-value:4.68E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.40|P-value:8.34E-41 ID:SGTC_1803|Compound:st050068|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.25|P-value:2.77E-10 ID:SGTC_2006|Compound:4011487|FD-Score:10.90|P-value:1.35E-27 ID:SGTC_2007|Compound:4011539|FD-Score:-3.72|P-value:1.05E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.29|P-value:5.05E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.89|P-value:5.92E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.36|P-value:4.43E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.20|P-value:7.70E-4 ID:SGTC_2359|Compound:9039622|FD-Score:6.02|P-value:1.17E-9 ID:SGTC_2374|Compound:9071832|FD-Score:4.76|P-value:1.16E-6 ID:SGTC_2472|Compound:5377652|FD-Score:10.40|P-value:3.87E-25 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.78|P-value:5.95E-15 ID:SGTC_2586|Compound:curcumin|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.73|P-value:1.37E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:5.93|P-value:2.07E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.85|P-value:5.36E-12 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.62|P-value:2.32E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.77|P-value:5.35E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:15.80|P-value:5.22E-56 ID:SGTC_2737|Compound:bleomycin|FD-Score:16.30|P-value:5.93E-59 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.65|P-value:1.50E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.29|P-value:5.07E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.14|P-value:2.02E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.25|P-value:6.46E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.42|P-value:3.17E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.23|P-value:1.10E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.82|P-value:7.60E-5 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.43|P-value:3.45E-4 ID:SGTC_3078|Compound:9116413|FD-Score:5.88|P-value:2.78E-9 ID:SGTC_3152|Compound:9099253|FD-Score:12.20|P-value:2.83E-34 ID:SGTC_3166|Compound:9102297|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_3218|Compound:9131285|FD-Score:8.25|P-value:1.32E-16 ID:SGTC_3242|Compound:9133940|FD-Score:-3.18|P-value:7.55E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.75|P-value:9.00E-5 ID:SGTC_3286|Compound:9117135|FD-Score:-3.10|P-value:9.75E-4

Top fitness defect scores for YDR456W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_206 4546-0025 27.60 72.0 µM 1.56E-165 NEO1 2 1.27E-167
2 SGTC_1781 st038725 24.60 66.3 µM 4.13E-132 NEO1 2 8.67E-134
3 SGTC_232 clozapine 19.50 119.0 µM 1.10E-83 NEO1 6 9.24E-85
4 SGTC_221 trifluoperazine 16.30 10.3 µM 3.71E-59 NEO1-PIK1 21 6.32E-60
5 SGTC_2737 bleomycin 16.30 30.5 nM 5.93E-59 Golgi 4 1.02E-59
6 SGTC_2697 mebhydrolin 15.80 72.4 µM 5.22E-56 NEO1 7 9.74E-57
7 SGTC_568 1193-0097 14.70 7.5 µM 1.27E-48 ERAD & cell cycle 4 2.94E-49
8 SGTC_888 0916-0002 14.60 7.0 µM 1.21E-47 NEO1 3 2.88E-48
9 SGTC_1789 tunicamycin 13.40 25.0 nM 8.34E-41 unfolded protein response 2 2.43E-41
10 SGTC_255 tunicamycin 12.30 200.5 nM 1.39E-34 unfolded protein response 7 4.87E-35
11 SGTC_3152 9099253 12.20 49.5 µM 2.83E-34 NEO1-PIK1 14 9.97E-35
12 SGTC_301 4119-0100 11.90 24.5 µM 2.32E-32 NEO1 11 8.65E-33
13 SGTC_2006 4011487 10.90 200.0 µM 1.35E-27 endomembrane recycling 12 5.79E-28
14 SGTC_2472 5377652 10.40 49.4 µM 3.87E-25 TRP & mitochondrial translation 10 1.79E-25
15 SGTC_1130 3454-2858 10.20 15.9 µM 2.49E-24 NEO1 14 1.18E-24
16 SGTC_637 1181-0519 9.65 7.3 µM 4.81E-22 fatty acid desaturase (OLE1) 21 2.44E-22
17 SGTC_1081 sertraline 8.97 6.0 µM 2.57E-19 60S ribosome export 4 1.42E-19
18 SGTC_263 alizarin 8.72 107.9 µM 2.40E-18 iron homeostasis 7 1.36E-18
19 SGTC_535 2293-4129 8.46 48.2 µM 2.35E-17 NEO1 11 1.37E-17
20 SGTC_3218 9131285 8.25 49.5 µM 1.32E-16 endomembrane recycling 7 7.91E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.750 0 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.518 2.07E-229 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.514 1.15E-225 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.505 2.86E-216 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.503 4.68E-214 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.468 2.30E-182 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.459 1.33E-174 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.456 6.89E-172 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.421 3.58E-144 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.418 5.69E-142 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.400 5.28E-129 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.397 7.51E-127 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.365 5.25E-106 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.359 1.08E-102 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.357 3.74E-101 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress