YDR459C / PFA5

Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR459C / PFA5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.84|P-value:7.43E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.16|P-value:1.62E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:2.97|P-value:4.52E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:2.88|P-value:6.34E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.10|P-value:2.58E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.73|P-value:1.57E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.78|P-value:1.19E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.46|P-value:5.34E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.79|P-value:1.11E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.17|P-value:1.98E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.94|P-value:5.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.88|P-value:6.57E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.86|P-value:2.72E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.01|P-value:9.08E-12 ID:SGTC_1610|Compound:st001799|FD-Score:-3.74|P-value:1.45E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:1.13E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.83|P-value:7.61E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.89|P-value:6.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.24|P-value:1.45E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.74|P-value:5.87E-8 ID:SGTC_2831|Compound:7999036|FD-Score:4.84|P-value:3.13E-8 ID:SGTC_2848|Compound:9016370|FD-Score:3.61|P-value:2.72E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.49|P-value:4.87E-5 ID:SGTC_2857|Compound:9024691|FD-Score:2.84|P-value:7.67E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.71|P-value:1.64E-5 ID:SGTC_2946|Compound:9065502|FD-Score:2.78|P-value:9.48E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.54|P-value:3.78E-5 ID:SGTC_3113|Compound:9123498|FD-Score:-3.85|P-value:8.31E-6 ID:SGTC_3118|Compound:9124250|FD-Score:2.77|P-value:9.82E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.19|P-value:1.83E-4 ID:SGTC_3122|Compound:9126309|FD-Score:-2.84|P-value:7.47E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.02|P-value:3.69E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.48|P-value:4.93E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.25|P-value:1.35E-4 ID:SGTC_3319|Compound:9138450|FD-Score:2.81|P-value:8.59E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-2.78|P-value:9.45E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-2.85|P-value:7.12E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.84|P-value:7.43E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.16|P-value:1.62E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:2.97|P-value:4.52E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:2.88|P-value:6.34E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.10|P-value:2.58E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.73|P-value:1.57E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.78|P-value:1.19E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.46|P-value:5.34E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.79|P-value:1.11E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.17|P-value:1.98E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.94|P-value:5.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.88|P-value:6.57E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.86|P-value:2.72E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.01|P-value:9.08E-12 ID:SGTC_1610|Compound:st001799|FD-Score:-3.74|P-value:1.45E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:1.13E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.83|P-value:7.61E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.89|P-value:6.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.24|P-value:1.45E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.74|P-value:5.87E-8 ID:SGTC_2831|Compound:7999036|FD-Score:4.84|P-value:3.13E-8 ID:SGTC_2848|Compound:9016370|FD-Score:3.61|P-value:2.72E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.49|P-value:4.87E-5 ID:SGTC_2857|Compound:9024691|FD-Score:2.84|P-value:7.67E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-3.71|P-value:1.64E-5 ID:SGTC_2946|Compound:9065502|FD-Score:2.78|P-value:9.48E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.54|P-value:3.78E-5 ID:SGTC_3113|Compound:9123498|FD-Score:-3.85|P-value:8.31E-6 ID:SGTC_3118|Compound:9124250|FD-Score:2.77|P-value:9.82E-4 ID:SGTC_3119|Compound:9125183|FD-Score:3.19|P-value:1.83E-4 ID:SGTC_3122|Compound:9126309|FD-Score:-2.84|P-value:7.47E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.02|P-value:3.69E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.48|P-value:4.93E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.25|P-value:1.35E-4 ID:SGTC_3319|Compound:9138450|FD-Score:2.81|P-value:8.59E-4 ID:SGTC_3320|Compound:9137005|FD-Score:-2.78|P-value:9.45E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-2.85|P-value:7.12E-4

Top fitness defect scores for YDR459C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2831 7999036 4.84 19.5 µM 3.13E-8 21 6.47E-7
2 SGTC_2829 7992743 4.74 58.4 µM 5.87E-8 20 1.07E-6
3 SGTC_114 0364-0001 4.16 490.3 µM 1.62E-6 46 1.56E-5
4 SGTC_958 1222-0007 3.79 33.0 µM 1.11E-5 31 7.39E-5
5 SGTC_919 tnp00227 3.78 403.6 nM 1.19E-5 RNA pol III & RNase P/MRP 41 7.79E-5
6 SGTC_669 0108-0021 3.73 26.2 µM 1.57E-5 fatty acid desaturase (OLE1) 92 9.76E-5
7 SGTC_2848 9016370 3.61 26.0 µM 2.72E-5 35 1.52E-4
8 SGTC_2997 9067075 3.54 71.4 µM 3.78E-5 unfolded protein response 68 1.99E-4
9 SGTC_2856 9022925 3.49 19.5 µM 4.87E-5 37 2.45E-4
10 SGTC_1611 st001856 3.30 99.4 µM 1.13E-4 41 4.84E-4
11 SGTC_3119 9125183 3.19 49.5 µM 1.83E-4 23 7.16E-4
12 SGTC_3224 9130643 3.02 49.5 µM 3.69E-4 RPP1 & pyrimidine depletion 71 0.00126
13 SGTC_149 3970-0822 2.97 46.1 µM 4.52E-4 tubulin folding & SWR complex 183 0.00149
14 SGTC_998 3996-0085 2.94 177.0 µM 5.15E-4 59 0.00166
15 SGTC_1774 st048371 2.89 48.5 µM 6.21E-4 RNA processing & uracil transport 73 0.00193
16 SGTC_235 0330-0087 2.88 5.0 mM 6.34E-4 TSC3-RPN4 83 0.00196
17 SGTC_1243 0416-0003 2.88 5.7 µM 6.57E-4 PDR1 90 0.00202
18 SGTC_2857 9024691 2.84 58.4 µM 7.67E-4 82 0.00229
19 SGTC_3319 9138450 2.81 16.8 µM 8.59E-4 71 0.00251
20 SGTC_2946 9065502 2.78 71.4 µM 9.48E-4 32 0.00272

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 3.47E-63 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.277 2.54E-60 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.269 1.71E-56 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.263 5.33E-54 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.259 1.83E-52 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.257 7.40E-52 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.253 3.57E-50 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.239 1.02E-44 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.238 1.60E-44 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.237 4.68E-44 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.236 9.59E-44 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.223 3.77E-39 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.220 3.95E-38 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.217 3.08E-37 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.216 7.35E-37 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension