YDR467C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR467C / YDR467C

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.53|P-value:3.43E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.49|P-value:4.01E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.67|P-value:2.08E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.34|P-value:6.63E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.83|P-value:1.74E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-5.05|P-value:6.87E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.31|P-value:7.93E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.09|P-value:4.26E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.44|P-value:4.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.17|P-value:1.60E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.27|P-value:8.89E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.42|P-value:5.07E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.33|P-value:6.86E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.74|P-value:1.80E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:2.61E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.30|P-value:8.25E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.35|P-value:6.43E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.53|P-value:6.65E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.31|P-value:7.26E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.32|P-value:1.64E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:7.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.68|P-value:2.01E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.97|P-value:7.56E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.46|P-value:4.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.77|P-value:3.67E-21 ID:SGTC_1868|Compound:st057644|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.99|P-value:6.83E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:9.22E-6 ID:SGTC_2021|Compound:4019055|FD-Score:12.50|P-value:3.38E-33 ID:SGTC_2138|Compound:5575593|FD-Score:-3.78|P-value:1.55E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.37|P-value:6.53E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.25|P-value:9.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.48|P-value:9.32E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.29|P-value:7.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.61E-25 ID:SGTC_2912|Compound:7964298|FD-Score:-3.36|P-value:6.69E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.46|P-value:4.37E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.53|P-value:3.43E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.49|P-value:4.01E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.67|P-value:2.08E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.34|P-value:6.63E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.76|P-value:1.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.83|P-value:1.74E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-5.05|P-value:6.87E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.31|P-value:7.93E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.09|P-value:4.26E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.44|P-value:4.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.17|P-value:1.60E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.27|P-value:8.89E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.42|P-value:5.07E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.33|P-value:6.86E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.74|P-value:1.80E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:2.61E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.30|P-value:8.25E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.35|P-value:6.43E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.53|P-value:6.65E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.31|P-value:7.26E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.32|P-value:1.64E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:7.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.68|P-value:2.01E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.97|P-value:7.56E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.46|P-value:4.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.77|P-value:3.67E-21 ID:SGTC_1868|Compound:st057644|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.99|P-value:6.83E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:9.22E-6 ID:SGTC_2021|Compound:4019055|FD-Score:12.50|P-value:3.38E-33 ID:SGTC_2138|Compound:5575593|FD-Score:-3.78|P-value:1.55E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.37|P-value:6.53E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.25|P-value:9.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.48|P-value:9.32E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.29|P-value:7.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.61E-25 ID:SGTC_2912|Compound:7964298|FD-Score:-3.36|P-value:6.69E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.46|P-value:4.37E-4

Top fitness defect scores for YDR467C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 12.50 173.0 µM 3.38E-33 endomembrane recycling 3 6.32E-36
2 SGTC_2688 kanamycin b 10.70 96.7 µM 4.61E-25 calcium & mitochondrial duress 20 4.45E-27
3 SGTC_1712 st032288 9.77 53.4 µM 3.67E-21 calcium & mitochondrial duress 25 7.77E-23
4 SGTC_658 3253-0951 6.17 102.0 µM 1.60E-9 calcium & mitochondrial duress 15 3.46E-10
5 SGTC_1206 3978-0017 5.32 132.0 µM 1.64E-7 ERG2 13 5.24E-8
6 SGTC_391 gliotoxin 4.83 8.3 µM 1.74E-6 43 6.79E-7
7 SGTC_1116 jasmonic acid 4.53 1.6 µM 6.65E-6 11 2.90E-6
8 SGTC_1913 st060213 4.46 96.1 µM 9.22E-6 18 4.13E-6
9 SGTC_528 3492-0019 4.09 172.0 µM 4.26E-5 calcium & mitochondrial duress 209 2.16E-5
10 SGTC_159 3970-0959 3.76 50.0 µM 1.53E-4 86 8.64E-5
11 SGTC_146 3448-8650 3.74 53.1 µM 1.65E-4 NEO1-PIK1 154 9.34E-5
12 SGTC_1508 1080-0625 3.68 72.9 µM 2.01E-4 25 1.16E-4
13 SGTC_108 0509-0257 3.67 621.1 µM 2.08E-4 62 1.20E-4
14 SGTC_1868 st057644 3.60 42.7 µM 2.65E-4 48 1.56E-4
15 SGTC_7 0192-1582 3.53 4.2 µM 3.43E-4 82 2.07E-4
16 SGTC_70 0141-0289 3.49 43.3 µM 4.01E-4 mitochondrial stress 215 2.44E-4
17 SGTC_3349 9149703 3.46 23.0 µM 4.37E-4 25 2.68E-4
18 SGTC_1584 6-fluoro-dl-tryptophan 3.46 90.0 µM 4.47E-4 mitochondrial processes 29 2.75E-4
19 SGTC_619 1652-1634 3.44 108.0 µM 4.78E-4 PDR1 34 2.95E-4
20 SGTC_727 3032-0951 3.42 202.0 µM 5.07E-4 43 3.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 2.12E-102 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.358 3.37E-102 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.322 9.11E-82 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.304 6.82E-73 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.292 4.36E-67 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.292 4.66E-67 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.288 3.50E-65 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.285 6.42E-64 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.272 5.22E-58 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.269 7.93E-57 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.259 2.47E-52 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.245 3.24E-47 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.239 9.56E-45 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.231 7.21E-42 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.230 1.51E-41 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome