YDR478W / SNM1

Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR478W / SNM1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.52|P-value:4.84E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.01|P-value:1.18E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:5.31|P-value:3.14E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.67|P-value:4.64E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.72|P-value:1.29E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.57|P-value:8.34E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.64|P-value:3.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.19|P-value:4.03E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.48|P-value:1.22E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.33|P-value:9.00E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.81|P-value:1.69E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.66|P-value:5.88E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.43|P-value:6.25E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.91|P-value:1.21E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.48|P-value:1.24E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.31|P-value:2.57E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.70|P-value:2.55E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.13|P-value:5.21E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.54|P-value:4.50E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.48|P-value:1.25E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-3.51|P-value:4.67E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.75|P-value:2.18E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.47|P-value:5.63E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.92|P-value:1.18E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.64|P-value:6.39E-6 ID:SGTC_2085|Compound:5307070|FD-Score:3.69|P-value:2.63E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.38|P-value:7.52E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.41|P-value:6.91E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.63|P-value:3.31E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.90|P-value:1.28E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-4.17|P-value:4.33E-5 ID:SGTC_2351|Compound:9026858|FD-Score:4.40|P-value:1.84E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.09|P-value:8.20E-7 ID:SGTC_2801|Compound:7907800|FD-Score:4.06|P-value:7.01E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.31|P-value:9.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.86|P-value:2.36E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-11.80|P-value:5.56E-29 ID:SGTC_2966|Compound:9084041|FD-Score:6.50|P-value:5.16E-10 ID:SGTC_3186|Compound:9110464|FD-Score:-3.57|P-value:3.85E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.94|P-value:1.08E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.52|P-value:4.84E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.01|P-value:1.18E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:5.31|P-value:3.14E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.67|P-value:4.64E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.72|P-value:1.29E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.57|P-value:8.34E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.64|P-value:3.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.19|P-value:4.03E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.48|P-value:1.22E-5 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.33|P-value:9.00E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:2.02E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.81|P-value:1.69E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.66|P-value:5.88E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.43|P-value:6.25E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.91|P-value:1.21E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.48|P-value:1.24E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.31|P-value:2.57E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.70|P-value:2.55E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.39|P-value:7.44E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.13|P-value:5.21E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.54|P-value:4.50E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.48|P-value:1.25E-5 ID:SGTC_1627|Compound:st003713|FD-Score:-3.51|P-value:4.67E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.75|P-value:2.18E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.47|P-value:5.63E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.92|P-value:1.18E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.64|P-value:6.39E-6 ID:SGTC_2085|Compound:5307070|FD-Score:3.69|P-value:2.63E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.38|P-value:7.52E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.41|P-value:6.91E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.63|P-value:3.31E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.90|P-value:1.28E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-4.17|P-value:4.33E-5 ID:SGTC_2351|Compound:9026858|FD-Score:4.40|P-value:1.84E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.09|P-value:8.20E-7 ID:SGTC_2801|Compound:7907800|FD-Score:4.06|P-value:7.01E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.31|P-value:9.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.86|P-value:2.36E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-11.80|P-value:5.56E-29 ID:SGTC_2966|Compound:9084041|FD-Score:6.50|P-value:5.16E-10 ID:SGTC_3186|Compound:9110464|FD-Score:-3.57|P-value:3.85E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.94|P-value:1.08E-4

Top fitness defect scores for YDR478W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2966 9084041 6.50 48.0 µM 5.16E-10 1 4.02E-11 2.56
2 SGTC_78 0336-0123 5.31 156.8 µM 3.14E-7 4 5.59E-8 0.82
3 SGTC_2351 9026858 4.40 72.3 µM 1.84E-5 RNA processing & uracil transport 8 5.50E-6 0.03
4 SGTC_1049 3226-0134 4.31 66.0 µM 2.57E-5 6 8.01E-6 0.28
5 SGTC_1240 0356-0016 4.13 42.1 µM 5.21E-5 mitochondrial response to ROS 5 1.78E-5 0.23
6 SGTC_2801 7907800 4.06 81.8 µM 7.01E-5 6 2.49E-5 0.35
7 SGTC_3349 9149703 3.94 23.0 µM 1.08E-4 1 4.05E-5 0.45
8 SGTC_1930 st074634 3.92 34.3 µM 1.18E-4 RNA pol III & RNase P/MRP 13 4.47E-5 0.01
9 SGTC_896 0964-0007 3.91 44.5 µM 1.21E-4 11 4.59E-5 0.41
10 SGTC_2296 7971656 3.90 126.5 µM 1.28E-4 7 4.90E-5 0.02
11 SGTC_453 enantio-paf c16 3.88 10.0 µM 1.35E-4 23 5.19E-5 0.25
12 SGTC_454 lyso-paf C-16 3.86 6.7 µM 1.44E-4 4 5.60E-5 0.05
13 SGTC_1629 st005085 3.75 44.9 µM 2.18E-4 RPP1 & pyrimidine depletion 14 8.92E-5 0.01
14 SGTC_1126 isoteolin 3.70 1.0 µM 2.55E-4 7 1.06E-4 0.10
15 SGTC_2085 5307070 3.69 144.1 µM 2.63E-4 superoxide 10 1.10E-4 0.06
16 SGTC_2203 7227154 3.63 166.4 µM 3.31E-4 3 1.43E-4 0.89
17 SGTC_1308 1187-1617 3.54 41.4 µM 4.50E-4 fatty acid desaturase (OLE1) 18 2.02E-4 0.10
18 SGTC_68 0986-0284 3.52 82.8 µM 4.84E-4 16 2.19E-4 0.02
19 SGTC_1664 st014217 3.47 9.0 µM 5.63E-4 60S ribosome export 11 2.59E-4 0.24
20 SGTC_2155 5570423 3.41 76.0 µM 6.91E-4 ergosterol biosynthesis 7 3.26E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.272 4.75E-58 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.270 4.14E-57 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.249 1.21E-48 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.218 2.50E-37 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.198 6.13E-31 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.195 3.73E-30 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.194 6.22E-30 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.190 1.13E-28 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.185 2.28E-27 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.183 1.23E-26 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.163 2.10E-21 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.148 7.84E-18 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.146 1.64E-17 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.146 1.82E-17 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.146 2.25E-17 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome