YDR479C / PEX29

Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR479C / PEX29

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.99|P-value:3.45E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.24|P-value:1.45E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.15|P-value:2.13E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.76|P-value:8.56E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.50|P-value:2.34E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:5.48|P-value:3.15E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.34|P-value:6.48E-8 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.37|P-value:4.45E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:5.53|P-value:2.28E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.61|P-value:1.52E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:3.20|P-value:8.05E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.35|P-value:4.89E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.46|P-value:5.26E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:4.44|P-value:5.76E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.98|P-value:4.42E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:7.82|P-value:5.31E-15 ID:SGTC_628|Compound:1636-0253|FD-Score:7.46|P-value:8.12E-14 ID:SGTC_649|Compound:1123-0311|FD-Score:5.91|P-value:2.58E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:9.71|P-value:3.60E-22 ID:SGTC_656|Compound:4090-1979|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.47|P-value:5.12E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:5.87|P-value:3.26E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:40.00|P-value:0 ID:SGTC_769|Compound:0302-0231|FD-Score:8.53|P-value:1.59E-17 ID:SGTC_778|Compound:3456-2434|FD-Score:3.97|P-value:4.59E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.54|P-value:2.45E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:9.49|P-value:2.79E-21 ID:SGTC_823|Compound:0417-1665|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.95|P-value:4.92E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:12.80|P-value:2.36E-37 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.86|P-value:7.81E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.87|P-value:6.64E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.64|P-value:1.81E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:33.90|P-value:1.37E-247 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.41|P-value:3.31E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:5.16|P-value:1.70E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.18|P-value:1.85E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.29|P-value:6.75E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.31|P-value:6.06E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.19|P-value:8.51E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.83|P-value:7.90E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.40|P-value:4.02E-4 ID:SGTC_1728|Compound:st035614|FD-Score:10.10|P-value:4.89E-24 ID:SGTC_1754|Compound:st042065|FD-Score:6.48|P-value:7.32E-11 ID:SGTC_1760|Compound:st045453|FD-Score:3.24|P-value:7.08E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.84|P-value:3.84E-9 ID:SGTC_1801|Compound:st050089|FD-Score:5.88|P-value:3.09E-9 ID:SGTC_1803|Compound:st050068|FD-Score:4.58|P-value:3.02E-6 ID:SGTC_1815|Compound:st051655|FD-Score:4.27|P-value:1.24E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.48|P-value:4.90E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.11|P-value:2.48E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_2079|Compound:5212404|FD-Score:4.31|P-value:1.07E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.70|P-value:1.76E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.80|P-value:9.10E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.16|P-value:9.43E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.51|P-value:2.66E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.58|P-value:2.11E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.26|P-value:1.30E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.35|P-value:1.85E-13 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.27|P-value:6.45E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.86|P-value:7.05E-5 ID:SGTC_2858|Compound:9025781|FD-Score:19.70|P-value:5.12E-85 ID:SGTC_2884|Compound:9058502|FD-Score:-3.25|P-value:5.71E-4 ID:SGTC_2886|Compound:9058944|FD-Score:-3.11|P-value:9.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:13.50|P-value:2.88E-41 ID:SGTC_3037|Compound:9091026|FD-Score:7.26|P-value:3.49E-13 ID:SGTC_3143|Compound:9086658|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.47|P-value:2.66E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.99|P-value:3.45E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.24|P-value:1.45E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.15|P-value:2.13E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.76|P-value:8.56E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.50|P-value:2.34E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:5.48|P-value:3.15E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.34|P-value:6.48E-8 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.37|P-value:4.45E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:5.53|P-value:2.28E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.61|P-value:1.52E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:3.20|P-value:8.05E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.35|P-value:4.89E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.46|P-value:5.26E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:4.44|P-value:5.76E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:4.98|P-value:4.42E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:7.82|P-value:5.31E-15 ID:SGTC_628|Compound:1636-0253|FD-Score:7.46|P-value:8.12E-14 ID:SGTC_649|Compound:1123-0311|FD-Score:5.91|P-value:2.58E-9 ID:SGTC_650|Compound:1328-0195|FD-Score:9.71|P-value:3.60E-22 ID:SGTC_656|Compound:4090-1979|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.47|P-value:5.12E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:5.87|P-value:3.26E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:40.00|P-value:0 ID:SGTC_769|Compound:0302-0231|FD-Score:8.53|P-value:1.59E-17 ID:SGTC_778|Compound:3456-2434|FD-Score:3.97|P-value:4.59E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.54|P-value:2.45E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:9.49|P-value:2.79E-21 ID:SGTC_823|Compound:0417-1665|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.95|P-value:4.92E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:12.80|P-value:2.36E-37 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.86|P-value:7.81E-7 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.87|P-value:6.64E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.64|P-value:1.81E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:33.90|P-value:1.37E-247 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.41|P-value:3.31E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:5.16|P-value:1.70E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.75|P-value:1.10E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.18|P-value:1.85E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.29|P-value:6.75E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.31|P-value:6.06E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.19|P-value:8.51E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.83|P-value:7.90E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.40|P-value:4.02E-4 ID:SGTC_1728|Compound:st035614|FD-Score:10.10|P-value:4.89E-24 ID:SGTC_1754|Compound:st042065|FD-Score:6.48|P-value:7.32E-11 ID:SGTC_1760|Compound:st045453|FD-Score:3.24|P-value:7.08E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.84|P-value:3.84E-9 ID:SGTC_1801|Compound:st050089|FD-Score:5.88|P-value:3.09E-9 ID:SGTC_1803|Compound:st050068|FD-Score:4.58|P-value:3.02E-6 ID:SGTC_1815|Compound:st051655|FD-Score:4.27|P-value:1.24E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.48|P-value:4.90E-6 ID:SGTC_2006|Compound:4011487|FD-Score:4.11|P-value:2.48E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_2079|Compound:5212404|FD-Score:4.31|P-value:1.07E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.70|P-value:1.76E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.80|P-value:9.10E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.16|P-value:9.43E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.51|P-value:2.66E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.58|P-value:2.11E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.26|P-value:1.30E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.35|P-value:1.85E-13 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.67|P-value:1.24E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.27|P-value:6.45E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.86|P-value:7.05E-5 ID:SGTC_2858|Compound:9025781|FD-Score:19.70|P-value:5.12E-85 ID:SGTC_2884|Compound:9058502|FD-Score:-3.25|P-value:5.71E-4 ID:SGTC_2886|Compound:9058944|FD-Score:-3.11|P-value:9.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:13.50|P-value:2.88E-41 ID:SGTC_3037|Compound:9091026|FD-Score:7.26|P-value:3.49E-13 ID:SGTC_3143|Compound:9086658|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.47|P-value:2.66E-4

Top fitness defect scores for YDR479C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_743 1275-0778 40.00 158.0 µM 0 excess fatty acid 1 0
2 SGTC_1255 0566-0045 33.90 221.0 µM 1.37E-247 excess fatty acid 1 9.70E-252
3 SGTC_2858 9025781 19.70 9.0 µM 5.12E-85 sphingolipid biosynthesis & PDR1 6 1.66E-86
4 SGTC_2896 9052656 13.50 71.4 µM 2.88E-41 endomembrane recycling 3 5.13E-42
5 SGTC_922 1866-0035 12.80 480.0 µM 2.36E-37 excess fatty acid 3 4.91E-38
6 SGTC_1728 st035614 10.10 33.8 µM 4.89E-24 2 1.74E-24
7 SGTC_650 1328-0195 9.71 38.0 µM 3.60E-22 1 1.38E-22
8 SGTC_795 0685-0265 9.49 78.0 µM 2.79E-21 excess fatty acid 1 1.11E-21
9 SGTC_769 0302-0231 8.53 76.0 µM 1.59E-17 3 7.41E-18
10 SGTC_541 4513-1321 7.82 94.0 µM 5.31E-15 2 2.74E-15
11 SGTC_628 1636-0253 7.46 16.0 µM 8.12E-14 sphingolipid biosynthesis & PDR1 6 4.41E-14
12 SGTC_2541 muurolladie-3-one 7.35 83.1 µM 1.85E-13 excess fatty acid 3 1.02E-13
13 SGTC_3037 9091026 7.26 49.5 µM 3.49E-13 NEO1-PIK1 21 1.95E-13
14 SGTC_1754 st042065 6.48 16.1 µM 7.32E-11 NEO1-PIK1 84 4.51E-11
15 SGTC_649 1123-0311 5.91 367.0 µM 2.58E-9 endomembrane recycling 26 1.70E-9
16 SGTC_1801 st050089 5.88 28.4 µM 3.09E-9 NEO1-PIK1 50 2.04E-9
17 SGTC_735 3076-0345 5.87 636.0 µM 3.26E-9 3 2.16E-9
18 SGTC_1800 st050079 5.84 29.1 µM 3.84E-9 NEO1-PIK1 42 2.55E-9
19 SGTC_335 4077-0256 5.61 27.6 µM 1.52E-8 4 1.03E-8
20 SGTC_293 4049-0273 5.53 38.5 µM 2.28E-8 5 1.57E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.608 0 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.297 1.49E-69 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.274 5.52E-59 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.262 5.87E-54 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.234 9.87E-43 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.231 5.76E-42 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.212 2.63E-35 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.195 3.80E-30 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.191 5.72E-29 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.189 2.09E-28 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.181 3.30E-26 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.179 1.83E-25 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.178 2.56E-25 YBR238C YBR238C hom Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.174 3.29E-24 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.174 4.25E-24 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton