YDR492W / IZH1

Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR492W / IZH1

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.14|P-value:6.85E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.68|P-value:8.95E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.86|P-value:4.23E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.64|P-value:1.11E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.89|P-value:3.66E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.43|P-value:2.39E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.57|P-value:1.65E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.96|P-value:2.82E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.77|P-value:6.13E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.09|P-value:8.05E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.48|P-value:1.97E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.45|P-value:3.00E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.48|P-value:2.45E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.87|P-value:4.07E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.02|P-value:2.09E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:1.73E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.00|P-value:2.36E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:-4.69|P-value:8.95E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.02|P-value:4.46E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.05|P-value:1.35E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.38|P-value:2.08E-8 ID:SGTC_1754|Compound:st042065|FD-Score:6.60|P-value:8.94E-12 ID:SGTC_1760|Compound:st045453|FD-Score:8.58|P-value:1.15E-18 ID:SGTC_1800|Compound:st050079|FD-Score:7.75|P-value:1.40E-15 ID:SGTC_1801|Compound:st050089|FD-Score:7.79|P-value:1.06E-15 ID:SGTC_1803|Compound:st050068|FD-Score:11.50|P-value:3.18E-32 ID:SGTC_1818|Compound:st052136|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.52|P-value:2.02E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.16|P-value:6.49E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.43|P-value:2.39E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:7.03E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.46|P-value:2.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.66|P-value:9.64E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-5.52|P-value:9.51E-9 ID:SGTC_3155|Compound:9099265|FD-Score:3.20|P-value:5.53E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.60|P-value:1.39E-6 ID:SGTC_3227|Compound:9130768|FD-Score:-3.61|P-value:1.18E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.08|P-value:8.53E-4 ID:SGTC_3255|Compound:9139072|FD-Score:5.12|P-value:9.28E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_3312|Compound:9133330|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:4.93E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.14|P-value:6.85E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.68|P-value:8.95E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.86|P-value:4.23E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.64|P-value:1.11E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.89|P-value:3.66E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.43|P-value:2.39E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.57|P-value:1.65E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.57|P-value:1.40E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.96|P-value:2.82E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.77|P-value:6.13E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.09|P-value:8.05E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.48|P-value:1.97E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.45|P-value:3.00E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.48|P-value:2.45E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.87|P-value:4.07E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.02|P-value:2.09E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:1.73E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.20|P-value:5.64E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.00|P-value:2.36E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:-4.69|P-value:8.95E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.02|P-value:4.46E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.05|P-value:1.35E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.38|P-value:2.08E-8 ID:SGTC_1754|Compound:st042065|FD-Score:6.60|P-value:8.94E-12 ID:SGTC_1760|Compound:st045453|FD-Score:8.58|P-value:1.15E-18 ID:SGTC_1800|Compound:st050079|FD-Score:7.75|P-value:1.40E-15 ID:SGTC_1801|Compound:st050089|FD-Score:7.79|P-value:1.06E-15 ID:SGTC_1803|Compound:st050068|FD-Score:11.50|P-value:3.18E-32 ID:SGTC_1818|Compound:st052136|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.52|P-value:2.02E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.11|P-value:7.75E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_2534|Compound:helenine|FD-Score:3.16|P-value:6.49E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.43|P-value:2.39E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.74|P-value:7.03E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.46|P-value:2.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.06|P-value:8.96E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.66|P-value:9.64E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-5.52|P-value:9.51E-9 ID:SGTC_3155|Compound:9099265|FD-Score:3.20|P-value:5.53E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.60|P-value:1.39E-6 ID:SGTC_3227|Compound:9130768|FD-Score:-3.61|P-value:1.18E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.08|P-value:8.53E-4 ID:SGTC_3255|Compound:9139072|FD-Score:5.12|P-value:9.28E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_3312|Compound:9133330|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.82|P-value:4.93E-5

Top fitness defect scores for YDR492W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1803 st050068 11.50 52.4 µM 3.18E-32 NEO1-PIK1 17 3.92E-31
2 SGTC_1760 st045453 8.58 10.4 µM 1.15E-18 NEO1-PIK1 44 4.67E-18
3 SGTC_1801 st050089 7.79 28.4 µM 1.06E-15 NEO1-PIK1 29 3.38E-15
4 SGTC_1800 st050079 7.75 29.1 µM 1.40E-15 NEO1-PIK1 13 4.43E-15
5 SGTC_1754 st042065 6.60 16.1 µM 8.94E-12 NEO1-PIK1 81 2.07E-11
6 SGTC_1712 st032288 5.38 53.4 µM 2.08E-8 calcium & mitochondrial duress 95 3.67E-8
7 SGTC_3255 9139072 5.12 49.5 µM 9.28E-8 3 1.55E-7
8 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.64 44.4 nM 1.11E-6 DNA damage response 23 1.70E-6
9 SGTC_649 1123-0311 4.57 367.0 µM 1.65E-6 endomembrane recycling 47 2.49E-6
10 SGTC_2021 4019055 4.52 173.0 µM 2.02E-6 endomembrane recycling 92 3.04E-6
11 SGTC_1266 0828-0227 4.48 32.9 µM 2.45E-6 14 3.65E-6
12 SGTC_1677 st019204 4.15 53.9 µM 1.17E-5 14 1.65E-5
13 SGTC_3312 9133330 4.05 71.4 µM 1.82E-5 4 2.53E-5
14 SGTC_1411 3909-8223 4.02 150.0 µM 2.09E-5 11 2.90E-5
15 SGTC_313 3474-0040 3.89 5.0 µM 3.66E-5 NEO1-PIK1 74 4.97E-5
16 SGTC_1409 3909-8004 3.87 61.9 µM 4.07E-5 20 5.51E-5
17 SGTC_260 nsc-65238 3.86 4.0 µM 4.23E-5 endomembrane recycling 18 5.71E-5
18 SGTC_3316 9136639 3.82 10.6 µM 4.93E-5 14 6.63E-5
19 SGTC_955 1216-0110 3.77 33.0 µM 6.13E-5 sphingolipid biosynthesis & PDR1 78 8.18E-5
20 SGTC_1423 4048-0112 3.75 5.6 µM 6.68E-5 28 8.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.434 1.62E-154 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.418 7.22E-142 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.417 5.78E-141 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.393 4.38E-124 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.382 7.56E-117 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.364 1.69E-105 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.354 7.16E-100 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.352 1.05E-98 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.342 6.59E-93 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.337 7.45E-90 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.337 1.27E-89 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.336 2.65E-89 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.336 3.71E-89 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.333 7.00E-88 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.328 7.26E-85 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin