HIPHOP chemogenomics database

YDR492W / IZH1

Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR492W / IZH1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR492W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1803	st050068	11.50	52.4 µM	3.18E-32	NEO1-PIK1	17	3.92E-31
2	SGTC_1760	st045453	8.58	10.4 µM	1.15E-18	NEO1-PIK1	44	4.67E-18
3	SGTC_1801	st050089	7.79	28.4 µM	1.06E-15	NEO1-PIK1	29	3.38E-15
4	SGTC_1800	st050079	7.75	29.1 µM	1.40E-15	NEO1-PIK1	13	4.43E-15
5	SGTC_1754	st042065	6.60	16.1 µM	8.94E-12	NEO1-PIK1	81	2.07E-11
6	SGTC_1712	st032288	5.38	53.4 µM	2.08E-8	calcium & mitochondrial duress	95	3.67E-8
7	SGTC_3255	9139072	5.12	49.5 µM	9.28E-8		3	1.55E-7
8	SGTC_267	4-Nitroquinoline-1-oxide (4-NQO)	4.64	44.4 nM	1.11E-6	DNA damage response	23	1.70E-6
9	SGTC_649	1123-0311	4.57	367.0 µM	1.65E-6	endomembrane recycling	47	2.49E-6
10	SGTC_2021	4019055	4.52	173.0 µM	2.02E-6	endomembrane recycling	92	3.04E-6
11	SGTC_1266	0828-0227	4.48	32.9 µM	2.45E-6		14	3.65E-6
12	SGTC_1677	st019204	4.15	53.9 µM	1.17E-5		14	1.65E-5
13	SGTC_3312	9133330	4.05	71.4 µM	1.82E-5		4	2.53E-5
14	SGTC_1411	3909-8223	4.02	150.0 µM	2.09E-5		11	2.90E-5
15	SGTC_313	3474-0040	3.89	5.0 µM	3.66E-5	NEO1-PIK1	74	4.97E-5
16	SGTC_1409	3909-8004	3.87	61.9 µM	4.07E-5		20	5.51E-5
17	SGTC_260	nsc-65238	3.86	4.0 µM	4.23E-5	endomembrane recycling	18	5.71E-5
18	SGTC_3316	9136639	3.82	10.6 µM	4.93E-5		14	6.63E-5
19	SGTC_955	1216-0110	3.77	33.0 µM	6.13E-5	sphingolipid biosynthesis & PDR1	78	8.18E-5
20	SGTC_1423	4048-0112	3.75	5.6 µM	6.68E-5		28	8.89E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.434	1.62E-154	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.418	7.22E-142	YPR091C	NVJ2	hom	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.417	5.78E-141	YPR092W_d	YPR092W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.393	4.38E-124	YNL267W	PIK1	het	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.382	7.56E-117	YOR357C	SNX3	hom	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.364	1.69E-105	YDR491C_d	YDR491C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.354	7.16E-100	YML097C	VPS9	hom	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.352	1.05E-98	YGL035C	MIG1	hom	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.342	6.59E-93	YDR084C	TVP23	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.337	7.45E-90	YAR042W	SWH1	hom	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.337	1.27E-89	YBR246W	RRT2	hom	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.336	2.65E-89	YDR093W	DNF2	hom	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.336	3.71E-89	YML037C_p	YML037C_p	hom	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.333	7.00E-88	YNL183C	NPR1	hom	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.328	7.26E-85	YHR108W	GGA2	hom	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin