YDR502C / SAM2

S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR502C / SAM2

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:6.96|P-value:2.72E-15 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.96|P-value:4.43E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.90|P-value:5.78E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.89|P-value:5.90E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.83|P-value:7.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-2.76|P-value:9.76E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.91|P-value:5.34E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.37|P-value:7.67E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.91|P-value:5.40E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.91|P-value:5.68E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.11|P-value:2.40E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.75|P-value:9.77E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.11|P-value:2.33E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.83|P-value:7.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.88|P-value:1.91E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.27|P-value:9.42E-13 ID:SGTC_1563|Compound:conessine|FD-Score:3.53|P-value:3.71E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.46|P-value:5.08E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-2.77|P-value:9.07E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.48|P-value:4.51E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.98|P-value:4.19E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.02|P-value:3.53E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.10|P-value:2.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.13|P-value:2.21E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.54|P-value:3.42E-5 ID:SGTC_2270|Compound:7924575|FD-Score:2.91|P-value:5.35E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.77|P-value:9.49E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.16|P-value:1.88E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.45|P-value:5.39E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.97|P-value:4.26E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.87|P-value:6.32E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.38|P-value:7.11E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.88|P-value:6.55E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.25|P-value:1.31E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.17|P-value:3.19E-9 ID:SGTC_2848|Compound:9016370|FD-Score:3.81|P-value:9.37E-6 ID:SGTC_2898|Compound:9056270|FD-Score:3.33|P-value:9.20E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.21|P-value:1.56E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.54|P-value:3.54E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.06|P-value:2.91E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.96|P-value:2.72E-15 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.96|P-value:4.43E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.90|P-value:5.78E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.89|P-value:5.90E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.83|P-value:7.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-2.76|P-value:9.76E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.91|P-value:5.34E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.37|P-value:7.67E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.91|P-value:5.40E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.91|P-value:5.68E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.11|P-value:2.40E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.75|P-value:9.77E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.11|P-value:2.33E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.83|P-value:7.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.88|P-value:1.91E-11 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.27|P-value:9.42E-13 ID:SGTC_1563|Compound:conessine|FD-Score:3.53|P-value:3.71E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.46|P-value:5.08E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-2.77|P-value:9.07E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.48|P-value:4.51E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.98|P-value:4.19E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.02|P-value:3.53E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.10|P-value:2.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.13|P-value:2.21E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.54|P-value:3.42E-5 ID:SGTC_2270|Compound:7924575|FD-Score:2.91|P-value:5.35E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.77|P-value:9.49E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:2.23E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.16|P-value:1.88E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.45|P-value:5.39E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.97|P-value:4.26E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.87|P-value:6.32E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.38|P-value:7.11E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.88|P-value:6.55E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.25|P-value:1.31E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.17|P-value:3.19E-9 ID:SGTC_2848|Compound:9016370|FD-Score:3.81|P-value:9.37E-6 ID:SGTC_2898|Compound:9056270|FD-Score:3.33|P-value:9.20E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.21|P-value:1.56E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.54|P-value:3.54E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.06|P-value:2.91E-4 ID:SGTC_3314|Compound:9135860|FD-Score:2.96|P-value:4.50E-4

Top fitness defect scores for YDR502C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 6.96 7.5 µM 2.72E-15 28 1.70E-12
2 SGTC_2814 7977482 5.17 43.0 µM 3.19E-9 15 1.16E-7
3 SGTC_2770 toltrazuril 3.97 17.5 µM 4.26E-6 26 3.67E-5
4 SGTC_1192 1488-0095 3.91 21.4 µM 5.68E-6 15 4.62E-5
5 SGTC_2848 9016370 3.81 26.0 µM 9.37E-6 28 6.90E-5
6 SGTC_2955 9076254 3.54 12.2 µM 3.54E-5 24 2.01E-4
7 SGTC_1563 conessine 3.53 56.1 µM 3.71E-5 28 2.08E-4
8 SGTC_1569 carminic acid 3.46 40.6 µM 5.08E-5 36 2.68E-4
9 SGTC_2516 gossypol 3.45 71.5 µM 5.39E-5 29 2.81E-4
10 SGTC_1119 parthenolide 3.37 318.5 nM 7.67E-5 TSC3-RPN4 68 3.73E-4
11 SGTC_2898 9056270 3.33 58.4 µM 9.20E-5 10 4.32E-4
12 SGTC_2811 7967822 3.25 32.5 µM 1.31E-4 39 5.74E-4
13 SGTC_2918 7977171 3.21 22.1 µM 1.56E-4 49 6.62E-4
14 SGTC_2125 5246583 3.13 200.0 µM 2.21E-4 tubulin folding & SWR complex 91 8.74E-4
15 SGTC_2359 9039622 3.13 200.0 µM 2.23E-4 endomembrane recycling 61 8.80E-4
16 SGTC_1251 0490-5699 3.11 265.0 µM 2.40E-4 74 9.33E-4
17 SGTC_2123 5259487 3.10 200.0 µM 2.46E-4 48 9.54E-4
18 SGTC_2118 5526350 3.02 200.0 µM 3.53E-4 49 0.00127
19 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 2.98 62.6 µM 4.19E-4 TSC3-RPN4 45 0.00146
20 SGTC_261 5-fluorouridine 2.96 15.4 µM 4.43E-4 exosome 57 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 4.20E-81 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.291 1.48E-66 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.291 3.47E-66 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.291 2.45E-66 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.280 2.53E-61 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.279 4.35E-61 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.274 9.85E-59 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.267 8.63E-56 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.250 4.36E-49 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.248 2.32E-48 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.229 4.42E-41 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.229 5.04E-41 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.226 5.81E-40 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.225 6.43E-40 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.224 1.45E-39 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C