YDR503C / LPP1

Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR503C / LPP1

Click on Significant Values for Screen Details ID:SGTC_260|Compound:nsc-65238|FD-Score:2.80|P-value:9.99E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.92|P-value:6.79E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.28|P-value:1.46E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_499|Compound:genistein|FD-Score:2.95|P-value:5.74E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.39|P-value:9.04E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.53|P-value:2.75E-7 ID:SGTC_707|Compound:0865-0008|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.03|P-value:3.76E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.62|P-value:3.14E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.01|P-value:4.23E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:3.52|P-value:4.97E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.25|P-value:1.64E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.26|P-value:1.23E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.36|P-value:9.44E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.10|P-value:3.11E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-2.95|P-value:5.11E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.82|P-value:8.48E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.60|P-value:3.52E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.38|P-value:9.35E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.03|P-value:4.05E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.22|P-value:1.86E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.17|P-value:2.18E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.19|P-value:2.16E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.81|P-value:9.55E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.35|P-value:9.97E-5 ID:SGTC_2206|Compound:7254556|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.08|P-value:3.30E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.87|P-value:9.70E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.22|P-value:1.87E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.50|P-value:5.16E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.76|P-value:1.47E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_2821|Compound:7996764|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.71|P-value:9.67E-8 ID:SGTC_3124|Compound:9127567|FD-Score:3.09|P-value:3.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.18|P-value:1.74E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.35|P-value:9.74E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.35|P-value:9.68E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.47|P-value:6.22E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.80|P-value:9.99E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.92|P-value:6.79E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.28|P-value:1.46E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_499|Compound:genistein|FD-Score:2.95|P-value:5.74E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.39|P-value:9.04E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.53|P-value:2.75E-7 ID:SGTC_707|Compound:0865-0008|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.03|P-value:3.76E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.62|P-value:3.14E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.01|P-value:4.23E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:3.52|P-value:4.97E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.25|P-value:1.64E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.26|P-value:1.23E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.36|P-value:9.44E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.10|P-value:3.11E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-2.95|P-value:5.11E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-2.82|P-value:8.48E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.60|P-value:3.52E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.38|P-value:9.35E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.03|P-value:4.05E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.22|P-value:1.86E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.17|P-value:2.18E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.19|P-value:2.16E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.81|P-value:9.55E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.35|P-value:9.97E-5 ID:SGTC_2206|Compound:7254556|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.08|P-value:3.30E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.87|P-value:9.70E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.22|P-value:1.87E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.50|P-value:5.16E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.76|P-value:1.47E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_2821|Compound:7996764|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.71|P-value:9.67E-8 ID:SGTC_3124|Compound:9127567|FD-Score:3.09|P-value:3.26E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.18|P-value:1.74E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.35|P-value:9.74E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.35|P-value:9.68E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.47|P-value:6.22E-5

Top fitness defect scores for YDR503C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2939 9044578 4.71 71.4 µM 9.67E-8 27 1.24E-6
2 SGTC_669 0108-0021 4.53 26.2 µM 2.75E-7 fatty acid desaturase (OLE1) 57 2.93E-6
3 SGTC_1135 dihydrocapsaicin 4.26 536.7 nM 1.23E-6 28 1.01E-5
4 SGTC_2419 paclitaxel 3.87 166.5 µM 9.70E-6 44 5.52E-5
5 SGTC_818 4072-2707 3.62 53.5 µM 3.14E-5 23 1.46E-4
6 SGTC_1348 1493-0373 3.60 93.8 µM 3.52E-5 20 1.60E-4
7 SGTC_963 1269-2853 3.52 151.0 µM 4.97E-5 38 2.13E-4
8 SGTC_3224 9130643 3.47 49.5 µM 6.22E-5 RPP1 & pyrimidine depletion 45 2.56E-4
9 SGTC_521 r062-0005 3.39 13.8 µM 9.04E-5 27 3.49E-4
10 SGTC_1359 1582-0056 3.38 520.0 nM 9.35E-5 37 3.59E-4
11 SGTC_423 5-fluorouracil 3.28 457.0 µM 1.46E-4 exosome 50 5.17E-4
12 SGTC_1119 parthenolide 3.25 318.5 nM 1.64E-4 TSC3-RPN4 79 5.71E-4
13 SGTC_1624 st003710 3.22 6.2 µM 1.86E-4 calcium & mitochondrial duress 72 6.35E-4
14 SGTC_2722 naftopidil 3.22 47.2 µM 1.87E-4 22 6.35E-4
15 SGTC_707 0865-0008 3.20 204.0 µM 2.01E-4 DNA damage response 25 6.76E-4
16 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.20 8.0 µM 2.08E-4 53 6.94E-4
17 SGTC_2031 5180455 3.19 200.0 µM 2.16E-4 35 7.17E-4
18 SGTC_1225 1216-0074 3.10 20.6 µM 3.11E-4 63 9.70E-4
19 SGTC_2818 7996756 3.09 13.0 µM 3.17E-4 41 9.85E-4
20 SGTC_3124 9127567 3.09 49.5 µM 3.26E-4 DNA damage response 45 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 5.53E-20 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.82E-14 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.126 2.54E-13 YDL094C_d YDL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential
0.124 5.90E-13 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.122 1.23E-12 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.116 1.70E-11 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.115 2.85E-11 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.109 2.14E-10 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.096 2.79E-8 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.53E-8 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.094 5.49E-8 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.091 1.31E-7 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.089 2.17E-7 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.089 2.30E-7 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.088 2.97E-7 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species