YDR504C / SPG3

Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR504C / SPG3

Click on Significant Values for Screen Details ID:SGTC_181|Compound:1447-1644|FD-Score:3.05|P-value:3.44E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.16|P-value:2.18E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.39|P-value:8.15E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.45|P-value:3.70E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.05|P-value:3.41E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.24|P-value:1.58E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.28|P-value:1.29E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.95|P-value:5.17E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.17|P-value:1.62E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.81|P-value:1.08E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.19|P-value:1.94E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.73|P-value:1.67E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.04|P-value:3.47E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:4.60E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.44|P-value:6.32E-5 ID:SGTC_2012|Compound:4023501|FD-Score:2.96|P-value:4.91E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-4.27|P-value:9.44E-7 ID:SGTC_2217|Compound:6934799|FD-Score:3.15|P-value:2.24E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-6.25|P-value:1.61E-12 ID:SGTC_2312|Compound:7706453|FD-Score:8.50|P-value:1.53E-21 ID:SGTC_2314|Compound:7727897|FD-Score:3.08|P-value:3.10E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.54|P-value:3.96E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.03|P-value:3.59E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.20|P-value:1.88E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.50|P-value:4.79E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.09|P-value:2.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.24|P-value:1.52E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.88|P-value:6.51E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.10|P-value:2.77E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.87|P-value:7.02E-4 ID:SGTC_3217|Compound:9129673|FD-Score:2.93|P-value:5.58E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.95|P-value:5.03E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-4.12|P-value:2.19E-6 ID:SGTC_3240|Compound:9133527|FD-Score:2.78|P-value:9.74E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.50|P-value:4.95E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-3.12|P-value:2.46E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.05|P-value:3.44E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.16|P-value:2.18E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.39|P-value:8.15E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.45|P-value:3.70E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.05|P-value:3.41E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.24|P-value:1.58E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.28|P-value:1.29E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.95|P-value:5.17E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.17|P-value:1.62E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.81|P-value:1.08E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.19|P-value:1.94E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.73|P-value:1.67E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.04|P-value:3.47E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.97|P-value:4.60E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.44|P-value:6.32E-5 ID:SGTC_2012|Compound:4023501|FD-Score:2.96|P-value:4.91E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-4.27|P-value:9.44E-7 ID:SGTC_2217|Compound:6934799|FD-Score:3.15|P-value:2.24E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-6.25|P-value:1.61E-12 ID:SGTC_2312|Compound:7706453|FD-Score:8.50|P-value:1.53E-21 ID:SGTC_2314|Compound:7727897|FD-Score:3.08|P-value:3.10E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.54|P-value:3.96E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.03|P-value:3.59E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.20|P-value:1.88E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.50|P-value:4.79E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.09|P-value:2.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.24|P-value:1.52E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.88|P-value:6.51E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.10|P-value:2.77E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.87|P-value:7.02E-4 ID:SGTC_3217|Compound:9129673|FD-Score:2.93|P-value:5.58E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.95|P-value:5.03E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-4.12|P-value:2.19E-6 ID:SGTC_3240|Compound:9133527|FD-Score:2.78|P-value:9.74E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.50|P-value:4.95E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-3.12|P-value:2.46E-4

Top fitness defect scores for YDR504C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2312 7706453 8.50 155.7 µM 1.53E-21 5 9.85E-18
2 SGTC_546 peri-Naphthalide 4.45 147.0 µM 3.70E-7 DNA damage response 12 4.35E-6
3 SGTC_2408 sulbentine 4.03 18.4 µM 3.59E-6 48 2.76E-5
4 SGTC_1215 3852-0577 3.73 11.2 µM 1.67E-5 21 9.68E-5
5 SGTC_3273 9137859 3.50 49.5 µM 4.95E-5 14 2.34E-4
6 SGTC_374 0880-0231 3.39 82.3 µM 8.15E-5 iron homeostasis 47 3.52E-4
7 SGTC_707 0865-0008 3.28 204.0 µM 1.29E-4 DNA damage response 21 5.13E-4
8 SGTC_2842 9000675 3.24 19.5 µM 1.52E-4 48 5.88E-4
9 SGTC_695 3505-6186 3.24 243.0 µM 1.58E-4 50 6.05E-4
10 SGTC_1728 st035614 3.22 33.8 µM 1.70E-4 91 6.43E-4
11 SGTC_2472 5377652 3.20 49.4 µM 1.88E-4 TRP & mitochondrial translation 96 6.97E-4
12 SGTC_1053 3366-3204 3.19 134.0 µM 1.94E-4 cell wall 65 7.16E-4
13 SGTC_285 1486-1325 3.16 46.0 µM 2.18E-4 46 7.87E-4
14 SGTC_2217 6934799 3.15 96.1 µM 2.24E-4 TSC3-RPN4 20 8.04E-4
15 SGTC_3075 9116269 3.10 49.5 µM 2.77E-4 47 9.59E-4
16 SGTC_2833 9001315 3.09 45.5 µM 2.93E-4 amide catabolism 95 0.00100
17 SGTC_2314 7727897 3.08 200.0 µM 3.10E-4 58 0.00105
18 SGTC_667 1498-1044 3.05 59.0 µM 3.41E-4 RPP1 & pyrimidine depletion 62 0.00114
19 SGTC_181 1447-1644 3.05 8.1 µM 3.44E-4 endomembrane recycling 70 0.00114
20 SGTC_2012 4023501 2.96 200.0 µM 4.91E-4 83 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.89E-16 YGR187C HGH1 hom Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
0.138 8.20E-16 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.128 9.98E-14 YDR282C_p YDR282C_p hom Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation
0.125 4.40E-13 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.116 1.77E-11 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.111 1.43E-10 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.101 4.63E-9 YFR023W PES4 hom Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication
0.098 1.23E-8 YJR112W NNF1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.098 1.39E-8 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.094 4.50E-8 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.43E-7 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.088 3.19E-7 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.088 3.76E-7 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.085 8.09E-7 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.084 1.19E-6 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication