YDR505C / PSP1

Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR505C / PSP1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.15|P-value:3.97E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.26|P-value:2.59E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.53|P-value:8.21E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.99|P-value:1.09E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.10|P-value:4.70E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:15.90|P-value:5.58E-65 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.02|P-value:9.28E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.11|P-value:2.57E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.95|P-value:8.40E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.12|P-value:4.48E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.98|P-value:7.53E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.30|P-value:2.35E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.00|P-value:9.94E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-3.09|P-value:4.95E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.12|P-value:4.45E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.00|P-value:6.99E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.96|P-value:8.28E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.66|P-value:5.01E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.32|P-value:3.82E-19 ID:SGTC_2909|Compound:7941780|FD-Score:3.03|P-value:6.28E-4 ID:SGTC_2978|Compound:9011784|FD-Score:5.18|P-value:1.73E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-4.52|P-value:7.06E-7 ID:SGTC_3080|Compound:9117754|FD-Score:3.40|P-value:1.52E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-5.03|P-value:4.12E-8 ID:SGTC_32|Compound:0928-0142|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.15|P-value:3.97E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.26|P-value:2.59E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.53|P-value:8.21E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.99|P-value:1.09E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.10|P-value:4.70E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:15.90|P-value:5.58E-65 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.02|P-value:9.28E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.11|P-value:2.57E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.95|P-value:8.40E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.12|P-value:4.48E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.98|P-value:7.53E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.30|P-value:2.35E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.00|P-value:9.94E-6 ID:SGTC_2000|Compound:st075254|FD-Score:-3.09|P-value:4.95E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.12|P-value:4.45E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.00|P-value:6.99E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.96|P-value:8.28E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.66|P-value:5.01E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.32|P-value:3.82E-19 ID:SGTC_2909|Compound:7941780|FD-Score:3.03|P-value:6.28E-4 ID:SGTC_2978|Compound:9011784|FD-Score:5.18|P-value:1.73E-8 ID:SGTC_3078|Compound:9116413|FD-Score:-4.52|P-value:7.06E-7 ID:SGTC_3080|Compound:9117754|FD-Score:3.40|P-value:1.52E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-5.03|P-value:4.12E-8

Top fitness defect scores for YDR505C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 15.90 1.8 µM 5.58E-65 3 1.43E-57
2 SGTC_2978 9011784 5.18 43.0 µM 1.73E-8 11 1.08E-7
3 SGTC_1741 st038134 4.30 10.2 µM 2.35E-6 24 8.43E-6
4 SGTC_1030 k029-0042 4.02 36.7 µM 9.28E-6 TSC3-RPN4 25 2.85E-5
5 SGTC_647 0140-0236 3.99 81.0 µM 1.09E-5 8 3.28E-5
6 SGTC_2693 st077581 3.82 40.7 µM 2.37E-5 40 6.55E-5
7 SGTC_2367 9070478 3.66 135.4 µM 5.01E-5 cell wall 43 1.27E-4
8 SGTC_603 3794-0023 3.42 45.9 µM 1.37E-4 21 3.12E-4
9 SGTC_3080 9117754 3.40 49.5 µM 1.52E-4 35 3.42E-4
10 SGTC_2514 salinomycin 3.39 42.7 µM 1.55E-4 79 3.48E-4
11 SGTC_1027 k015-0025 3.35 8.7 µM 1.84E-4 50 4.06E-4
12 SGTC_32 0928-0142 3.29 34.1 µM 2.35E-4 TSC3-RPN4 18 5.03E-4
13 SGTC_1333 1482-0047 3.20 286.0 µM 3.35E-4 44 6.91E-4
14 SGTC_1412 3909-8563 3.12 178.0 µM 4.48E-4 35 8.94E-4
15 SGTC_2909 7941780 3.03 10.5 µM 6.28E-4 52 0.00121
16 SGTC_1520 flindersine 3.03 88.0 µM 6.35E-4 73 0.00122
17 SGTC_2359 9039622 2.96 200.0 µM 8.28E-4 endomembrane recycling 74 0.00155
18 SGTC_1262 0737-0114 2.95 49.6 µM 8.40E-4 66 0.00157
19 SGTC_515 4092-1064 2.90 102.0 µM 0.00102 plasma membrane duress 120 0.00185
20 SGTC_2736 butenafine 2.85 14.7 µM 0.00122 84 0.00219

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.598 9.88E-324 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.443 2.68E-161 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.431 1.59E-151 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.428 1.89E-149 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.398 3.94E-127 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.369 9.10E-109 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.358 6.62E-102 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.353 5.41E-99 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.348 6.29E-96 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.342 3.54E-92 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.313 7.12E-77 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.309 3.65E-75 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.303 6.68E-72 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.294 5.42E-68 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.293 2.13E-67 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C