YDR512C / EMI1

Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR512C / EMI1

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:6.54|P-value:1.16E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:3.76|P-value:1.27E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.10|P-value:3.07E-61 ID:SGTC_310|Compound:1273-0058|FD-Score:3.17|P-value:9.77E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.07|P-value:5.53E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.38|P-value:6.74E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.17|P-value:9.77E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.29|P-value:6.65E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.27|P-value:9.54E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.30|P-value:8.77E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.57|P-value:3.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.87|P-value:8.18E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.51|P-value:4.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.03|P-value:6.49E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.82|P-value:1.42E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.10|P-value:1.65E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.34|P-value:5.52E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.77|P-value:2.79E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.73|P-value:1.98E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-4.83|P-value:2.06E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.96|P-value:3.75E-9 ID:SGTC_1725|Compound:st036284|FD-Score:9.82|P-value:1.11E-21 ID:SGTC_1728|Compound:st035614|FD-Score:4.96|P-value:7.20E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-7.24|P-value:2.35E-12 ID:SGTC_1742|Compound:st038235|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:1.13E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:4.12E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.63|P-value:2.01E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.95|P-value:8.63E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.98|P-value:3.31E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.59|P-value:3.29E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.20|P-value:3.57E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.89|P-value:7.64E-5 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.26|P-value:9.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.85|P-value:1.27E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.70|P-value:3.74E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.15|P-value:4.03E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-3.38|P-value:6.81E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.77|P-value:1.74E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.40|P-value:6.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.98|P-value:7.78E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:2.07E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.75|P-value:1.29E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.12|P-value:3.10E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.94|P-value:6.33E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.54|P-value:1.16E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:3.76|P-value:1.27E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.59|P-value:2.32E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.10|P-value:3.07E-61 ID:SGTC_310|Compound:1273-0058|FD-Score:3.17|P-value:9.77E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.68|P-value:1.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.07|P-value:5.53E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.38|P-value:6.74E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.17|P-value:9.77E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.29|P-value:6.65E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.27|P-value:9.54E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.30|P-value:8.77E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.57|P-value:3.50E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.87|P-value:8.18E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.51|P-value:4.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.03|P-value:6.49E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.82|P-value:1.42E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.10|P-value:1.65E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.34|P-value:5.52E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.77|P-value:2.79E-6 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.73|P-value:1.98E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-4.83|P-value:2.06E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.96|P-value:3.75E-9 ID:SGTC_1725|Compound:st036284|FD-Score:9.82|P-value:1.11E-21 ID:SGTC_1728|Compound:st035614|FD-Score:4.96|P-value:7.20E-7 ID:SGTC_1733|Compound:st037357|FD-Score:-7.24|P-value:2.35E-12 ID:SGTC_1742|Compound:st038235|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:1.13E-6 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:4.12E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.21|P-value:8.64E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.50|P-value:3.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.63|P-value:2.01E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.95|P-value:8.63E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.98|P-value:3.31E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.59|P-value:3.29E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.20|P-value:3.57E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.89|P-value:7.64E-5 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.18|P-value:9.59E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.26|P-value:9.97E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.85|P-value:1.27E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.70|P-value:3.74E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.15|P-value:4.03E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-3.38|P-value:6.81E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.77|P-value:1.74E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.40|P-value:6.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.98|P-value:7.78E-5 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:2.07E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.75|P-value:1.29E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.12|P-value:3.10E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.94|P-value:6.33E-5

Top fitness defect scores for YDR512C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 17.10 5.3 µM 3.07E-61 75 1.16E-65
2 SGTC_1725 st036284 9.82 20.6 µM 1.11E-21 2 4.49E-23
3 SGTC_149 3970-0822 6.54 46.1 µM 1.16E-10 tubulin folding & SWR complex 30 3.03E-11
4 SGTC_1294 1000-1494 6.10 117.0 µM 1.65E-9 16 5.20E-10
5 SGTC_2564 betulinic acid 5.98 100.0 µM 3.31E-9 7 1.10E-9
6 SGTC_1359 1582-0056 5.96 520.0 nM 3.75E-9 1 1.25E-9
7 SGTC_1728 st035614 4.96 33.8 µM 7.20E-7 24 3.47E-7
8 SGTC_3309 9129340 4.12 25.8 µM 3.10E-5 11 1.93E-5
9 SGTC_3344 9148862 3.94 3.9 µM 6.33E-5 9 4.12E-5
10 SGTC_2638 epoxomicin 3.89 18.0 µM 7.64E-5 37 5.03E-5
11 SGTC_1020 4335-0961 3.87 93.3 µM 8.18E-5 17 5.41E-5
12 SGTC_163 1327-0036 3.76 7.5 µM 1.27E-4 117 8.62E-5
13 SGTC_3225 9130819 3.75 49.5 µM 1.29E-4 amide catabolism 32 8.78E-5
14 SGTC_1742 st038235 3.69 28.9 µM 1.62E-4 mitochondrial stress 127 1.12E-4
15 SGTC_410 α-linolenic acid 3.68 100.0 µM 1.70E-4 excess fatty acid 44 1.18E-4
16 SGTC_2523 spermine 3.63 47.7 µM 2.01E-4 calcium & mitochondrial duress 34 1.41E-4
17 SGTC_212 3807-4682 3.59 38.8 µM 2.32E-4 tubulin folding & SWR complex 91 1.64E-4
18 SGTC_2514 salinomycin 3.50 42.7 µM 3.20E-4 72 2.31E-4
19 SGTC_1902 st060212 3.43 70.5 µM 4.12E-4 24 3.02E-4
20 SGTC_1306 1185-0270 3.34 9.0 µM 5.52E-4 Golgi 70 4.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.382 8.55E-117 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.378 2.79E-114 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.368 8.09E-108 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.368 6.11E-108 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.361 1.46E-103 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.359 2.19E-102 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.358 5.61E-102 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.357 1.07E-101 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.346 7.59E-95 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.341 7.02E-92 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.332 5.56E-87 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.326 8.29E-84 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.325 2.93E-83 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.325 5.20E-83 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.321 2.84E-81 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex