HIPHOP chemogenomics database

YDR512C / EMI1

Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR512C / EMI1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR512C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	17.10	5.3 µM	3.07E-61		75	1.16E-65
2	SGTC_1725	st036284	9.82	20.6 µM	1.11E-21		2	4.49E-23
3	SGTC_149	3970-0822	6.54	46.1 µM	1.16E-10	tubulin folding & SWR complex	30	3.03E-11
4	SGTC_1294	1000-1494	6.10	117.0 µM	1.65E-9		16	5.20E-10
5	SGTC_2564	betulinic acid	5.98	100.0 µM	3.31E-9		7	1.10E-9
6	SGTC_1359	1582-0056	5.96	520.0 nM	3.75E-9		1	1.25E-9
7	SGTC_1728	st035614	4.96	33.8 µM	7.20E-7		24	3.47E-7
8	SGTC_3309	9129340	4.12	25.8 µM	3.10E-5		11	1.93E-5
9	SGTC_3344	9148862	3.94	3.9 µM	6.33E-5		9	4.12E-5
10	SGTC_2638	epoxomicin	3.89	18.0 µM	7.64E-5		37	5.03E-5
11	SGTC_1020	4335-0961	3.87	93.3 µM	8.18E-5		17	5.41E-5
12	SGTC_163	1327-0036	3.76	7.5 µM	1.27E-4		117	8.62E-5
13	SGTC_3225	9130819	3.75	49.5 µM	1.29E-4	amide catabolism	32	8.78E-5
14	SGTC_1742	st038235	3.69	28.9 µM	1.62E-4	mitochondrial stress	127	1.12E-4
15	SGTC_410	α-linolenic acid	3.68	100.0 µM	1.70E-4	excess fatty acid	44	1.18E-4
16	SGTC_2523	spermine	3.63	47.7 µM	2.01E-4	calcium & mitochondrial duress	34	1.41E-4
17	SGTC_212	3807-4682	3.59	38.8 µM	2.32E-4	tubulin folding & SWR complex	91	1.64E-4
18	SGTC_2514	salinomycin	3.50	42.7 µM	3.20E-4		72	2.31E-4
19	SGTC_1902	st060212	3.43	70.5 µM	4.12E-4		24	3.02E-4
20	SGTC_1306	1185-0270	3.34	9.0 µM	5.52E-4	Golgi	70	4.12E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.382	8.55E-117	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.378	2.79E-114	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.368	8.09E-108	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.368	6.11E-108	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.361	1.46E-103	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.359	2.19E-102	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.358	5.61E-102	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.357	1.07E-101	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.346	7.59E-95	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.341	7.02E-92	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.332	5.56E-87	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.326	8.29E-84	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.325	2.93E-83	YLL033W	IRC19	hom	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.325	5.20E-83	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit
0.321	2.84E-81	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex