HIPHOP chemogenomics database

YDR513W / GRX2

Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR513W / GRX2

Click on Significant Values for Screen Details

Top fitness defect scores for YDR513W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1718	roemerine	7.00	11.9 µM	4.02E-14	redox potentiating	12	1.31E-12
2	SGTC_2584	androsterone	5.86	48.7 µM	1.94E-10	cell wall	62	2.30E-9
3	SGTC_2586	curcumin	5.28	80.0 µM	8.46E-9	iron homeostasis	28	6.39E-8
4	SGTC_3211	9128781	5.14	49.5 µM	1.99E-8		33	1.36E-7
5	SGTC_2696	st077691	4.99	74.3 µM	4.82E-8		15	2.97E-7
6	SGTC_940	3232-1287	4.93	54.8 µM	6.96E-8	NEO1	15	4.10E-7
7	SGTC_946	3434-1334	4.89	87.4 µM	8.77E-8		12	5.02E-7
8	SGTC_939	1165-0479	4.84	45.3 µM	1.14E-7		12	6.35E-7
9	SGTC_607	4491-0986	4.75	66.8 µM	1.98E-7	heme requiring	13	1.03E-6
10	SGTC_1825	st052143	4.29	62.6 µM	2.24E-6		9	8.76E-6
11	SGTC_608	k048-0125	4.20	159.0 µM	3.69E-6		24	1.36E-5
12	SGTC_803	4488-1585	3.69	147.0 µM	4.02E-5		18	1.12E-4
13	SGTC_1004	4084-0029	3.58	199.0 µM	6.46E-5		26	1.70E-4
14	SGTC_988	1497-1057	3.39	103.0 µM	1.43E-4		22	3.43E-4
15	SGTC_2324	6149169	3.31	200.0 µM	2.00E-4		32	4.62E-4
16	SGTC_1350	1495-0454	3.26	146.0 µM	2.44E-4		59	5.52E-4
17	SGTC_212	3807-4682	3.21	38.8 µM	2.97E-4	tubulin folding & SWR complex	120	6.56E-4
18	SGTC_1885	st057546	3.15	99.9 µM	3.81E-4		44	8.18E-4
19	SGTC_2004	4023728	3.14	41.9 µM	3.92E-4		66	8.39E-4
20	SGTC_1334	1486-0610	3.01	236.0 µM	6.50E-4	60S ribosome export	57	0.00131

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.164	1.12E-21	YKL185W	ASH1	hom	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.162	4.49E-21	YDR376W	ARH1	het	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.143	8.68E-17	YLR363W-A	YLR363W-A	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.138	8.24E-16	YOR195W	SLK19	hom	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.129	5.34E-14	YER069W	ARG5,6	hom	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.128	9.68E-14	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.128	1.02E-13	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.126	2.22E-13	YHR042W	NCP1	het	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.118	6.03E-12	YOL140W	ARG8	hom	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.118	5.82E-12	YGR123C	PPT1	hom	Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.116	1.72E-11	YJR149W_p	YJR149W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.116	1.75E-11	YDR514C	YDR514C	hom	Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
0.114	3.06E-11	YGL047W	ALG13	het	Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress
0.112	7.19E-11	YBL085W	BOI1	hom	Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.109	2.72E-10	YDL224C	WHI4	hom	Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication