HIPHOP chemogenomics database

YDR523C / SPS1

Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR523C / SPS1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR523C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3195	9113082	4.27	49.5 µM	6.53E-8		13	9.75E-6
2	SGTC_1313	1220-0047	3.66	237.0 µM	3.03E-6		50	1.26E-4
3	SGTC_696	1560-0013	3.43	611.0 µM	1.12E-5		39	3.02E-4
4	SGTC_2835	9006588	3.22	71.4 µM	3.48E-5		81	6.45E-4
5	SGTC_426	0988-0037	3.17	14.6 µM	4.52E-5	ERAD & cell cycle	68	7.68E-4
6	SGTC_2768	sulfasalazine	3.12	50.2 µM	5.87E-5		48	9.16E-4
7	SGTC_1563	conessine	3.10	56.1 µM	6.36E-5		46	9.66E-4
8	SGTC_1143	3454-2408	3.09	5.1 µM	6.64E-5	60S ribosome export	17	9.95E-4
9	SGTC_3189	9110682	3.07	49.5 µM	7.38E-5		69	0.00107
10	SGTC_1146	3579-1023	3.03	7.0 µM	9.24E-5		51	0.00124
11	SGTC_431	k089-0097	3.01	107.0 µM	9.95E-5	iron homeostasis	101	0.00131
12	SGTC_2002	4023503	2.99	131.0 µM	1.08E-4	mitochondrial processes	91	0.00138
13	SGTC_1287	0971-0001	2.91	34.6 µM	1.59E-4	sphingolipid biosynthesis & PDR1	102	0.00179
14	SGTC_3042	9091578	2.87	49.5 µM	1.93E-4	ERG2	36	0.00204
15	SGTC_1376	2910-0861	2.65	41.3 µM	5.23E-4		103	0.00400
16	SGTC_735	3076-0345	2.62	636.0 µM	6.06E-4		131	0.00442
17	SGTC_1230	0170-0365	2.59	3.8 µM	6.77E-4	endomembrane recycling	208	0.00477
18	SGTC_2091	4-phenylthiadiazole	2.59	200.0 µM	6.96E-4		96	0.00486
19	SGTC_637	1181-0519	2.58	7.3 µM	7.03E-4	fatty acid desaturase (OLE1)	214	0.00489
20	SGTC_267	4-Nitroquinoline-1-oxide (4-NQO)	2.58	44.4 nM	7.09E-4	DNA damage response	99	0.00492

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.139	6.93E-16	YHL006C	SHU1	hom	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.124	5.82E-13	YCR030C	SYP1	hom	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.110	1.81E-10	YGR067C_p	YGR067C_p	hom	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.107	4.82E-10	YDR171W	HSP42	hom	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.098	1.40E-8	YOL123W	HRP1	het	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
0.095	3.78E-8	YDR094W_d	YDR094W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.092	9.96E-8	YBL065W_d	YBL065W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.090	1.57E-7	YMR039C	SUB1	hom	Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.089	2.12E-7	YGL210W	YPT32	hom	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.089	2.56E-7	YBR256C	RIB5	het	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.089	2.88E-7	YDR277C	MTH1	hom	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.085	8.52E-7	YFL052W_p	YFL052W_p	hom	Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.084	9.54E-7	YNL074C	MLF3	hom	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.084	1.16E-6	YFL007W	BLM10	hom	Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.083	1.40E-6	YBR197C	YBR197C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication