YDR523C / SPS1

Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR523C / SPS1

Click on Significant Values for Screen Details ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.58|P-value:7.09E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.61|P-value:6.46E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.17|P-value:4.52E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.01|P-value:9.95E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:2.58|P-value:7.03E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.74|P-value:3.57E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.43|P-value:1.12E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.16|P-value:4.74E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:2.62|P-value:6.06E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.09|P-value:6.64E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.03|P-value:9.24E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.59|P-value:6.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-2.62|P-value:6.17E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-2.59|P-value:6.76E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.70|P-value:4.18E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:2.91|P-value:1.59E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.58|P-value:7.20E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.66|P-value:3.03E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.65|P-value:5.23E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.52|P-value:9.13E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-2.91|P-value:1.65E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.10|P-value:6.36E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.16|P-value:1.38E-7 ID:SGTC_1897|Compound:st060201|FD-Score:-3.29|P-value:2.43E-5 ID:SGTC_1953|Compound:st076800|FD-Score:2.54|P-value:8.38E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.99|P-value:1.08E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:2.59|P-value:6.96E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.99|P-value:1.12E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.83|P-value:2.35E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.12|P-value:5.87E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.62|P-value:6.10E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.17|P-value:4.55E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.41|P-value:1.28E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.22|P-value:3.48E-5 ID:SGTC_3042|Compound:9091578|FD-Score:2.87|P-value:1.93E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.07|P-value:7.38E-5 ID:SGTC_3195|Compound:9113082|FD-Score:4.27|P-value:6.53E-8 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.58|P-value:7.09E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-2.61|P-value:6.46E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.17|P-value:4.52E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.01|P-value:9.95E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:2.58|P-value:7.03E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.74|P-value:3.57E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.43|P-value:1.12E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.16|P-value:4.74E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:2.62|P-value:6.06E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.09|P-value:6.64E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.03|P-value:9.24E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.59|P-value:6.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-2.62|P-value:6.17E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-2.59|P-value:6.76E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-2.70|P-value:4.18E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:2.91|P-value:1.59E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.58|P-value:7.20E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.66|P-value:3.03E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.65|P-value:5.23E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:2.52|P-value:9.13E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-2.91|P-value:1.65E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.10|P-value:6.36E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-4.16|P-value:1.38E-7 ID:SGTC_1897|Compound:st060201|FD-Score:-3.29|P-value:2.43E-5 ID:SGTC_1953|Compound:st076800|FD-Score:2.54|P-value:8.38E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.99|P-value:1.08E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:2.59|P-value:6.96E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.99|P-value:1.12E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.83|P-value:2.35E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.12|P-value:5.87E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.62|P-value:6.10E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.17|P-value:4.55E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.41|P-value:1.28E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.22|P-value:3.48E-5 ID:SGTC_3042|Compound:9091578|FD-Score:2.87|P-value:1.93E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.07|P-value:7.38E-5 ID:SGTC_3195|Compound:9113082|FD-Score:4.27|P-value:6.53E-8

Top fitness defect scores for YDR523C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3195 9113082 4.27 49.5 µM 6.53E-8 13 9.75E-6
2 SGTC_1313 1220-0047 3.66 237.0 µM 3.03E-6 50 1.26E-4
3 SGTC_696 1560-0013 3.43 611.0 µM 1.12E-5 39 3.02E-4
4 SGTC_2835 9006588 3.22 71.4 µM 3.48E-5 81 6.45E-4
5 SGTC_426 0988-0037 3.17 14.6 µM 4.52E-5 ERAD & cell cycle 68 7.68E-4
6 SGTC_2768 sulfasalazine 3.12 50.2 µM 5.87E-5 48 9.16E-4
7 SGTC_1563 conessine 3.10 56.1 µM 6.36E-5 46 9.66E-4
8 SGTC_1143 3454-2408 3.09 5.1 µM 6.64E-5 60S ribosome export 17 9.95E-4
9 SGTC_3189 9110682 3.07 49.5 µM 7.38E-5 69 0.00107
10 SGTC_1146 3579-1023 3.03 7.0 µM 9.24E-5 51 0.00124
11 SGTC_431 k089-0097 3.01 107.0 µM 9.95E-5 iron homeostasis 101 0.00131
12 SGTC_2002 4023503 2.99 131.0 µM 1.08E-4 mitochondrial processes 91 0.00138
13 SGTC_1287 0971-0001 2.91 34.6 µM 1.59E-4 sphingolipid biosynthesis & PDR1 102 0.00179
14 SGTC_3042 9091578 2.87 49.5 µM 1.93E-4 ERG2 36 0.00204
15 SGTC_1376 2910-0861 2.65 41.3 µM 5.23E-4 103 0.00400
16 SGTC_735 3076-0345 2.62 636.0 µM 6.06E-4 131 0.00442
17 SGTC_1230 0170-0365 2.59 3.8 µM 6.77E-4 endomembrane recycling 208 0.00477
18 SGTC_2091 4-phenylthiadiazole 2.59 200.0 µM 6.96E-4 96 0.00486
19 SGTC_637 1181-0519 2.58 7.3 µM 7.03E-4 fatty acid desaturase (OLE1) 214 0.00489
20 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 2.58 44.4 nM 7.09E-4 DNA damage response 99 0.00492

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.93E-16 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.124 5.82E-13 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.110 1.81E-10 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.107 4.82E-10 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.098 1.40E-8 YOL123W HRP1 het Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
0.095 3.78E-8 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.092 9.96E-8 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.090 1.57E-7 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.089 2.12E-7 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.089 2.56E-7 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.089 2.88E-7 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.085 8.52E-7 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.084 9.54E-7 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.084 1.16E-6 YFL007W BLM10 hom Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.083 1.40E-6 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication