YDR530C / APA2

Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR530C / APA2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.11|P-value:5.30E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.64|P-value:5.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:5.22|P-value:3.84E-11 ID:SGTC_264|Compound:promethazine|FD-Score:-2.68|P-value:4.24E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:2.51|P-value:8.56E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.98|P-value:3.49E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.68|P-value:4.25E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.81|P-value:2.32E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.01|P-value:8.59E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:2.51|P-value:8.89E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.04|P-value:7.63E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.61|P-value:1.29E-12 ID:SGTC_715|Compound:0868-0130|FD-Score:-2.91|P-value:1.47E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.71|P-value:3.77E-4 ID:SGTC_918|Compound:glabranin|FD-Score:2.51|P-value:8.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.25|P-value:5.73E-8 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.54|P-value:7.65E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.96|P-value:4.02E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.32|P-value:1.79E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.58|P-value:6.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.46|P-value:5.03E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.38|P-value:1.07E-11 ID:SGTC_1518|Compound:st038567|FD-Score:-2.67|P-value:4.52E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.19|P-value:3.39E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.68|P-value:4.24E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.59|P-value:6.21E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-2.59|P-value:6.37E-4 ID:SGTC_2218|Compound:6965428|FD-Score:2.71|P-value:3.70E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.30|P-value:1.94E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.17|P-value:9.73E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:3.03|P-value:7.91E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.62|P-value:5.53E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.78|P-value:2.66E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:2.51|P-value:8.81E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.79|P-value:2.56E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.45|P-value:8.23E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-5.13|P-value:8.13E-11 ID:SGTC_2913|Compound:7966556|FD-Score:-2.78|P-value:2.74E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.48|P-value:9.75E-4 ID:SGTC_2941|Compound:9056145|FD-Score:2.72|P-value:3.42E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.87|P-value:1.75E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-2.91|P-value:1.42E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.08|P-value:6.33E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-2.80|P-value:2.41E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.65|P-value:4.84E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-2.81|P-value:2.37E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.11|P-value:5.30E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.64|P-value:5.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:5.22|P-value:3.84E-11 ID:SGTC_264|Compound:promethazine|FD-Score:-2.68|P-value:4.24E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:2.51|P-value:8.56E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.98|P-value:3.49E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.68|P-value:4.25E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-2.81|P-value:2.32E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.01|P-value:8.59E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:2.51|P-value:8.89E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.04|P-value:7.63E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.61|P-value:1.29E-12 ID:SGTC_715|Compound:0868-0130|FD-Score:-2.91|P-value:1.47E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.71|P-value:3.77E-4 ID:SGTC_918|Compound:glabranin|FD-Score:2.51|P-value:8.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.25|P-value:5.73E-8 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.54|P-value:7.65E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.96|P-value:4.02E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.32|P-value:1.79E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.58|P-value:6.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.46|P-value:5.03E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.38|P-value:1.07E-11 ID:SGTC_1518|Compound:st038567|FD-Score:-2.67|P-value:4.52E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.19|P-value:3.39E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.68|P-value:4.24E-4 ID:SGTC_1774|Compound:st048371|FD-Score:2.59|P-value:6.21E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-2.59|P-value:6.37E-4 ID:SGTC_2218|Compound:6965428|FD-Score:2.71|P-value:3.70E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.30|P-value:1.94E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.17|P-value:9.73E-8 ID:SGTC_2563|Compound:tomatine|FD-Score:3.03|P-value:7.91E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.62|P-value:5.53E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.78|P-value:2.66E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:2.51|P-value:8.81E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.79|P-value:2.56E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.45|P-value:8.23E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-5.13|P-value:8.13E-11 ID:SGTC_2913|Compound:7966556|FD-Score:-2.78|P-value:2.74E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.48|P-value:9.75E-4 ID:SGTC_2941|Compound:9056145|FD-Score:2.72|P-value:3.42E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.87|P-value:1.75E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-2.91|P-value:1.42E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.08|P-value:6.33E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-2.80|P-value:2.41E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-2.65|P-value:4.84E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-2.81|P-value:2.37E-4

Top fitness defect scores for YDR530C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_513 4245-1575 5.61 41.7 µM 1.29E-12 unfolded protein response 58 9.92E-9
2 SGTC_226 1,3-diallylurea 5.22 8.3 mM 3.84E-11 5 9.02E-8
3 SGTC_1043 0916-0009 4.25 19.3 µM 5.73E-8 17 1.06E-5
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.17 3.7 µM 9.73E-8 73 1.50E-5
5 SGTC_1153 4055-0057 3.96 267.0 µM 4.02E-7 25 3.80E-5
6 SGTC_2844 9010103 3.45 26.0 µM 8.23E-6 48 2.76E-4
7 SGTC_1553 gossypol 3.19 38.6 µM 3.39E-5 7 7.02E-4
8 SGTC_6 0844-0013 3.11 19.8 µM 5.30E-5 188 9.41E-4
9 SGTC_480 am 92016 3.04 50.0 µM 7.63E-5 50 0.00120
10 SGTC_2563 tomatine 3.03 8.5 µM 7.91E-5 107 0.00123
11 SGTC_418 lividomycin a 3.01 100.0 µM 8.59E-5 46 0.00130
12 SGTC_2989 9073649 2.87 71.4 µM 1.75E-4 111 0.00207
13 SGTC_2941 9056145 2.72 11.2 µM 3.42E-4 59 0.00324
14 SGTC_2218 6965428 2.71 193.0 µM 3.70E-4 TSC3-RPN4 49 0.00341
15 SGTC_1774 st048371 2.59 48.5 µM 6.21E-4 RNA processing & uracil transport 111 0.00482
16 SGTC_1244 0416-0015 2.58 52.5 µM 6.46E-4 ERG2 136 0.00495
17 SGTC_1138 3761-0006 2.54 1.0 µM 7.65E-4 56 0.00554
18 SGTC_327 1273-0057 2.51 4.0 µM 8.56E-4 azole & statin 109 0.00597
19 SGTC_918 glabranin 2.51 770.7 nM 8.72E-4 125 0.00604
20 SGTC_2659 sanguinarine 2.51 24.2 µM 8.81E-4 100 0.00608

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.378 2.47E-114 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.323 1.70E-82 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.317 7.41E-79 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.306 1.86E-73 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.292 6.65E-67 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.289 1.66E-65 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.275 2.85E-59 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.273 1.67E-58 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.273 3.21E-58 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.271 1.82E-57 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.255 7.81E-51 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.254 3.02E-50 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.252 9.34E-50 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.246 1.50E-47 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.246 1.56E-47 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress