YDR533C / HSP31

Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR533C / HSP31

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.38|P-value:1.23E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.71|P-value:5.66E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.31|P-value:1.62E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.70|P-value:5.73E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.34|P-value:6.99E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.17|P-value:4.35E-13 ID:SGTC_119|Compound:0121-0043|FD-Score:3.88|P-value:3.35E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.58|P-value:3.02E-14 ID:SGTC_168|Compound:3970-0862|FD-Score:7.08|P-value:2.82E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:6.95|P-value:5.78E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:18.30|P-value:6.77E-58 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.70|P-value:4.44E-21 ID:SGTC_343|Compound:4130-2827|FD-Score:5.66|P-value:3.51E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.57|P-value:9.63E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.01|P-value:1.60E-15 ID:SGTC_419|Compound:nsc-638432|FD-Score:-5.38|P-value:1.45E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.52|P-value:8.07E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.59|P-value:8.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.70|P-value:6.69E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.10|P-value:3.95E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.64|P-value:6.99E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.76|P-value:5.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.41|P-value:5.47E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.13|P-value:3.51E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.45|P-value:5.62E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.93|P-value:6.46E-10 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.77|P-value:5.34E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.35|P-value:1.36E-8 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.56|P-value:8.93E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.95|P-value:2.60E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.38|P-value:6.04E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.68|P-value:6.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.80|P-value:3.09E-25 ID:SGTC_1742|Compound:st038235|FD-Score:5.31|P-value:1.64E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:8.36E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.53|P-value:9.61E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.14|P-value:1.43E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.95|P-value:2.99E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.71|P-value:1.83E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.69|P-value:2.35E-9 ID:SGTC_2283|Compound:7944793|FD-Score:3.84|P-value:3.78E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:5.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.53|P-value:9.66E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.58|P-value:9.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.56|P-value:8.80E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.27|P-value:9.11E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.98|P-value:2.75E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.80|P-value:1.29E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:5.38|P-value:1.23E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.71|P-value:5.66E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.31|P-value:1.62E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.70|P-value:5.73E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.34|P-value:6.99E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.17|P-value:4.35E-13 ID:SGTC_119|Compound:0121-0043|FD-Score:3.88|P-value:3.35E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.58|P-value:3.02E-14 ID:SGTC_168|Compound:3970-0862|FD-Score:7.08|P-value:2.82E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:6.95|P-value:5.78E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:18.30|P-value:6.77E-58 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.70|P-value:4.44E-21 ID:SGTC_343|Compound:4130-2827|FD-Score:5.66|P-value:3.51E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.57|P-value:9.63E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.01|P-value:1.60E-15 ID:SGTC_419|Compound:nsc-638432|FD-Score:-5.38|P-value:1.45E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.52|P-value:8.07E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.59|P-value:8.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.70|P-value:6.69E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.10|P-value:3.95E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.64|P-value:6.99E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.76|P-value:5.47E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.41|P-value:5.47E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.13|P-value:3.51E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.45|P-value:5.62E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.93|P-value:6.46E-10 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.77|P-value:5.34E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.35|P-value:1.36E-8 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.56|P-value:8.93E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.95|P-value:2.60E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.38|P-value:6.04E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.68|P-value:6.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.80|P-value:3.09E-25 ID:SGTC_1742|Compound:st038235|FD-Score:5.31|P-value:1.64E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:8.36E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.53|P-value:9.61E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.14|P-value:1.43E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.95|P-value:2.99E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.71|P-value:1.83E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.69|P-value:2.35E-9 ID:SGTC_2283|Compound:7944793|FD-Score:3.84|P-value:3.78E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:5.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.53|P-value:9.66E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.58|P-value:9.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.56|P-value:8.80E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.27|P-value:9.11E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.98|P-value:2.75E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.80|P-value:1.29E-5

Top fitness defect scores for YDR533C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 18.30 5.3 µM 6.77E-58 67 3.67E-75
2 SGTC_1635 st007035 11.80 42.4 µM 3.09E-25 61 2.08E-32
3 SGTC_275 trichlorophene 10.70 5.7 µM 4.44E-21 mitochondrial stress 36 5.67E-27
4 SGTC_386 1509-0011 9.01 3.1 µM 1.60E-15 53 1.02E-19
5 SGTC_134 0269-0018 8.58 6.9 µM 3.02E-14 54 4.74E-18
6 SGTC_70 0141-0289 8.17 43.3 µM 4.35E-13 mitochondrial stress 38 1.54E-16
7 SGTC_168 3970-0862 7.08 530.5 µM 2.82E-10 28 7.08E-13
8 SGTC_173 1273-0061 6.95 2.7 µM 5.78E-10 mitochondrial stress 89 1.80E-12
9 SGTC_908 3448-7491 6.93 47.7 µM 6.46E-10 mitochondrial stress 27 2.08E-12
10 SGTC_2250 alverine citrate 6.69 130.0 µM 2.35E-9 39 1.12E-11
11 SGTC_1188 1403-0014 6.35 4.6 µM 1.36E-8 mitochondrial stress 16 1.10E-10
12 SGTC_343 4130-2827 5.66 29.8 µM 3.51E-7 6 7.44E-9
13 SGTC_10 0279-0212 5.38 42.6 µM 1.23E-6 TRP & mitochondrial translation 45 3.78E-8
14 SGTC_38 0929-0051 5.31 58.3 µM 1.62E-6 5 5.43E-8
15 SGTC_1742 st038235 5.31 28.9 µM 1.64E-6 mitochondrial stress 68 5.49E-8
16 SGTC_767 0929-0023 5.13 86.0 µM 3.51E-6 TRP & mitochondrial translation 32 1.48E-7
17 SGTC_596 1155-0152 5.10 116.0 µM 3.95E-6 TRP & mitochondrial translation 14 1.72E-7
18 SGTC_3338 9144300 4.80 39.6 µM 1.29E-5 Golgi 11 7.96E-7
19 SGTC_2238 6671620 4.71 73.2 µM 1.83E-5 14 1.24E-6
20 SGTC_748 0136-0228 4.41 77.9 µM 5.47E-5 redox potentiating 64 5.14E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.617 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.603 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.595 5.05E-320 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.582 5.38E-303 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.567 3.69E-285 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.563 7.96E-280 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.560 1.80E-276 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.547 2.24E-261 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.545 4.24E-259 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.544 3.72E-258 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.540 1.90E-253 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.540 6.49E-253 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.533 2.60E-245 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.528 1.26E-240 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.526 9.99E-239 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit