YDR534C / FIT1

Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR534C / FIT1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.39|P-value:6.20E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.94|P-value:4.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.87|P-value:5.52E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.71|P-value:9.95E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.21|P-value:1.35E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.71|P-value:3.16E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.35|P-value:1.26E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.06|P-value:5.14E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.73|P-value:1.23E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.96|P-value:3.92E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.90|P-value:4.77E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.03|P-value:5.93E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.89|P-value:4.95E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-2.94|P-value:8.33E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.82|P-value:6.68E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.78|P-value:7.59E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.92|P-value:4.51E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:5.35E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.48|P-value:4.05E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.94|P-value:4.37E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.79|P-value:7.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.76|P-value:8.12E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.92|P-value:4.37E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.28|P-value:9.98E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.39|P-value:6.20E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:2.94|P-value:4.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.87|P-value:5.52E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.71|P-value:9.95E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.21|P-value:1.35E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.71|P-value:3.16E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.35|P-value:1.26E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.30|P-value:1.97E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.06|P-value:5.14E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.73|P-value:1.23E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.96|P-value:3.92E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.90|P-value:4.77E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.03|P-value:5.93E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.89|P-value:4.95E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-2.94|P-value:8.33E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.82|P-value:6.68E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.78|P-value:7.59E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.92|P-value:4.51E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.42|P-value:5.35E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.48|P-value:4.05E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.94|P-value:4.37E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.79|P-value:7.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.76|P-value:8.12E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.92|P-value:4.37E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.28|P-value:9.98E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.03|P-value:5.95E-4

Top fitness defect scores for YDR534C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1271 0832-2808 3.96 169.0 µM 3.92E-6 11 3.77E-5
2 SGTC_2563 tomatine 3.94 8.5 µM 4.37E-6 46 4.12E-5
3 SGTC_1004 4084-0029 3.73 199.0 µM 1.23E-5 20 9.53E-5
4 SGTC_2335 9018011 3.48 154.2 µM 4.05E-5 41 2.50E-4
5 SGTC_2331 7980721 3.42 200.0 µM 5.35E-5 42 3.14E-4
6 SGTC_38 0929-0051 3.39 58.3 µM 6.20E-5 40 3.54E-4
7 SGTC_3153 9100258 3.28 49.5 µM 9.98E-5 52 5.20E-4
8 SGTC_1581 himbacine 3.25 57.9 µM 1.15E-4 Golgi 66 5.82E-4
9 SGTC_366 0181-0206 3.21 4.3 µM 1.35E-4 Golgi 77 6.64E-4
10 SGTC_39 0986-0283 2.94 58.4 µM 4.08E-4 calcium & mitochondrial duress 90 0.00163
11 SGTC_2859 9028643 2.92 45.5 µM 4.37E-4 52 0.00172
12 SGTC_2298 7976326 2.92 193.8 µM 4.51E-4 36 0.00177
13 SGTC_1291 0993-0025 2.90 5.8 µM 4.77E-4 41 0.00185
14 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 2.89 66.5 µM 4.95E-4 50 0.00191
15 SGTC_41 0478-0632 2.87 82.6 µM 5.52E-4 90 0.00208
16 SGTC_1705 st027868 2.82 56.3 µM 6.68E-4 60 0.00243
17 SGTC_2567 aureobasidin a 2.79 60.0 nM 7.51E-4 182 0.00267
18 SGTC_1716 st033144 2.78 30.6 µM 7.59E-4 76 0.00269
19 SGTC_2784 7567673 2.76 72.7 µM 8.12E-4 iron homeostasis 100 0.00285
20 SGTC_266 formosanin C 2.71 406.0 nM 9.95E-4 sphingolipid biosynthesis & PDR1 155 0.00336

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.44E-45 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.193 2.31E-29 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.172 1.35E-23 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.167 1.87E-22 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.161 7.91E-21 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.149 3.28E-18 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.147 9.31E-18 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.147 1.22E-17 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.143 8.10E-17 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.141 2.28E-16 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.141 2.70E-16 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.135 4.73E-15 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.134 6.97E-15 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.131 2.62E-14 YLL060C GTT2 hom Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
0.128 8.65E-14 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock