YEL001C / IRC22

Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL001C / IRC22

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:2.80|P-value:6.31E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.70|P-value:7.92E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.57|P-value:5.08E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.29|P-value:7.30E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.72|P-value:2.58E-15 ID:SGTC_180|Compound:1486-1293|FD-Score:3.08|P-value:1.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.75|P-value:6.04E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:1.01E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.33|P-value:5.13E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.89|P-value:4.19E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.07|P-value:1.73E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.81|P-value:5.14E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.95|P-value:3.27E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.80|P-value:6.15E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.99|P-value:2.37E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.82|P-value:5.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-2.88|P-value:3.85E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.95|P-value:2.45E-6 ID:SGTC_1795|Compound:st049545|FD-Score:2.77|P-value:7.02E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.75|P-value:7.54E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.75|P-value:6.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.71|P-value:7.62E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.85|P-value:5.01E-4 ID:SGTC_2338|Compound:7999974|FD-Score:5.23|P-value:6.99E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.08|P-value:1.64E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.89|P-value:3.75E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:1.82E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.70|P-value:8.02E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.35|P-value:4.66E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.17|P-value:1.26E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.13|P-value:1.50E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.35|P-value:5.47E-5 ID:SGTC_2839|Compound:9003951|FD-Score:4.32|P-value:2.88E-7 ID:SGTC_2840|Compound:9008771|FD-Score:2.84|P-value:5.20E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.64|P-value:1.29E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.88|P-value:4.40E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.72|P-value:8.60E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:2.80|P-value:6.31E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.70|P-value:7.92E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.57|P-value:5.08E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:3.29|P-value:7.30E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.72|P-value:2.58E-15 ID:SGTC_180|Compound:1486-1293|FD-Score:3.08|P-value:1.86E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.75|P-value:6.04E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:1.01E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.33|P-value:5.13E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.89|P-value:4.19E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.07|P-value:1.73E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.81|P-value:5.14E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.95|P-value:3.27E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.80|P-value:6.15E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.99|P-value:2.37E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.82|P-value:5.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:-2.88|P-value:3.85E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.95|P-value:2.45E-6 ID:SGTC_1795|Compound:st049545|FD-Score:2.77|P-value:7.02E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.75|P-value:7.54E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.75|P-value:6.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.71|P-value:7.62E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.85|P-value:5.01E-4 ID:SGTC_2338|Compound:7999974|FD-Score:5.23|P-value:6.99E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.08|P-value:1.64E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.89|P-value:3.75E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:1.82E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.70|P-value:8.02E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.35|P-value:4.66E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.17|P-value:1.26E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.13|P-value:1.50E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.35|P-value:5.47E-5 ID:SGTC_2839|Compound:9003951|FD-Score:4.32|P-value:2.88E-7 ID:SGTC_2840|Compound:9008771|FD-Score:2.84|P-value:5.20E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.64|P-value:1.29E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.88|P-value:4.40E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.72|P-value:8.60E-4

Top fitness defect scores for YEL001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2338 7999974 5.23 200.0 µM 6.99E-10 5 8.28E-8
2 SGTC_2839 9003951 4.32 26.0 µM 2.88E-7 7 7.65E-6
3 SGTC_2453 5731132 4.01 22.2 µM 1.82E-6 21 3.08E-5
4 SGTC_1714 st033236 3.95 13.6 µM 2.45E-6 22 3.85E-5
5 SGTC_2843 9000894 3.64 45.5 µM 1.29E-5 15 1.35E-4
6 SGTC_2810 7959871 3.35 45.5 µM 5.47E-5 copper-dependent oxidative stress 65 4.04E-4
7 SGTC_163 1327-0036 3.29 7.5 µM 7.30E-5 160 5.03E-4
8 SGTC_940 3232-1287 3.22 54.8 µM 1.01E-4 NEO1 70 6.46E-4
9 SGTC_2692 st077426 3.17 47.7 µM 1.26E-4 55 7.60E-4
10 SGTC_2693 st077581 3.13 40.7 µM 1.50E-4 82 8.67E-4
11 SGTC_180 1486-1293 3.08 102.8 µM 1.86E-4 80 0.00102
12 SGTC_1311 1190-0148 2.95 100.0 µM 3.27E-4 azole & statin 71 0.00157
13 SGTC_1246 0422-0085 2.89 105.0 µM 4.19E-4 94 0.00190
14 SGTC_2847 9005661 2.88 71.4 µM 4.40E-4 30 0.00197
15 SGTC_2336 9001819 2.85 198.7 µM 5.01E-4 heme biosynthesis & mitochondrial translocase 122 0.00218
16 SGTC_2840 9008771 2.84 71.4 µM 5.20E-4 47 0.00224
17 SGTC_1379 2144-0755 2.80 36.5 µM 6.15E-4 81 0.00255
18 SGTC_63 0099-0242 2.80 26.7 µM 6.31E-4 mitochondrial stress 174 0.00259
19 SGTC_1795 st049545 2.77 62.3 µM 7.02E-4 TSC3-RPN4 62 0.00281
20 SGTC_1996 st072960 2.75 66.8 µM 7.54E-4 70 0.00297

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 7.45E-59 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.224 3.00E-39 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.219 1.34E-37 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.209 1.85E-34 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.206 1.71E-33 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.190 1.01E-28 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.186 1.31E-27 YOL055C THI20 hom Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
0.180 6.81E-26 YGL255W ZRT1 hom High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.162 2.90E-21 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.157 7.15E-20 YBR071W YBR071W hom Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
0.156 1.15E-19 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.154 2.63E-19 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.150 3.17E-18 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.149 4.63E-18 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.131 2.76E-14 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres