YEL004W / YEA4

Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL004W / YEA4

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.65|P-value:1.53E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.37|P-value:7.95E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:2.90|P-value:4.38E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:4.84|P-value:1.68E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.77|P-value:0.00100 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.59|P-value:1.28E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:2.86|P-value:5.27E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.04|P-value:3.45E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.42|P-value:6.46E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.98|P-value:3.20E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.03|P-value:2.55E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.00|P-value:2.97E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.06|P-value:2.33E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.71|P-value:9.26E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.72|P-value:9.12E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.93|P-value:5.22E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.72|P-value:9.16E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.71|P-value:9.33E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.02|P-value:3.75E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.77|P-value:1.17E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.30|P-value:1.09E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.50|P-value:1.41E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.37|P-value:5.77E-5 ID:SGTC_2935|Compound:9038016|FD-Score:2.91|P-value:4.32E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.64|P-value:1.60E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.65|P-value:1.53E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.37|P-value:7.95E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:2.90|P-value:4.38E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:4.84|P-value:1.68E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.77|P-value:0.00100 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.59|P-value:1.28E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:2.86|P-value:5.27E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.04|P-value:3.45E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.42|P-value:6.46E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.98|P-value:3.20E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.03|P-value:2.55E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.00|P-value:2.97E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.06|P-value:2.33E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.71|P-value:9.26E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.72|P-value:9.12E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.93|P-value:5.22E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.72|P-value:9.16E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.71|P-value:9.33E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.02|P-value:3.75E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.77|P-value:1.17E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.30|P-value:1.09E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.50|P-value:1.41E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.37|P-value:5.77E-5 ID:SGTC_2935|Compound:9038016|FD-Score:2.91|P-value:4.32E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.64|P-value:1.60E-5

Top fitness defect scores for YEL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_284 0988-0104 4.84 32.6 µM 1.68E-8 heme requiring 6 6.40E-7
2 SGTC_2288 7946289 4.50 167.3 µM 1.41E-7 16 3.38E-6
3 SGTC_67 0335-0847 3.65 266.0 µM 1.53E-5 ubiquinone biosynthesis & proteasome 136 1.33E-4
4 SGTC_3202 9113761 3.64 49.5 µM 1.60E-5 59 1.38E-4
5 SGTC_2605 digitonin 3.37 300.0 nM 5.77E-5 54 3.75E-4
6 SGTC_1284 0929-0043 3.06 16.0 µM 2.33E-4 66 0.00112
7 SGTC_1270 0831-1170 3.03 17.3 µM 2.55E-4 46 0.00121
8 SGTC_1276 0871-0068 3.00 94.2 µM 2.97E-4 51 0.00136
9 SGTC_1231 0242-0792 2.98 125.0 µM 3.20E-4 64 0.00144
10 SGTC_2935 9038016 2.91 30.0 µM 4.32E-4 67 0.00182
11 SGTC_279 1273-0055 2.90 2.9 µM 4.38E-4 azole & statin 93 0.00184
12 SGTC_763 3453-1109 2.86 128.0 µM 5.27E-4 66 0.00213
13 SGTC_1343 1487-0095 2.72 224.0 µM 9.12E-4 53 0.00328
14 SGTC_1521 st012942 2.72 49.4 µM 9.16E-4 117 0.00329
15 SGTC_1332 1480-0653 2.71 17.5 µM 9.26E-4 TSC3-RPN4 86 0.00332
16 SGTC_1600 coumarin 106 2.71 71.1 µM 9.33E-4 94 0.00334
17 SGTC_2970 9090938 2.64 41.9 µM 0.00121 RNA processing & uracil transport 155 0.00410
18 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 2.63 67.5 µM 0.00130 138 0.00433
19 SGTC_249 wiskostatin 2.60 11.2 µM 0.00141 77 0.00463
20 SGTC_2932 9016711 2.59 44.5 µM 0.00146 153 0.00475

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.275 3.23E-59 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.257 1.64E-51 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.249 1.30E-48 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.246 1.68E-47 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.244 1.11E-46 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.234 7.97E-43 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.219 1.10E-37 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.217 3.50E-37 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.216 1.04E-36 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.215 1.62E-36 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.213 1.04E-35 YLR267W_p BOP2_p hom Protein of unknown function
0.210 6.79E-35 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.210 8.52E-35 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.208 4.40E-34 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.204 9.86E-33 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder