HIPHOP chemogenomics database

YEL026W / SNU13

RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein

Zygosity: Heterozygous strain

fixedexpanded
Profile for YEL026W / SNU13

Click on Significant Values for Screen Details

Top fitness defect scores for YEL026W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_518	1021-0119	4.09	62.6 µM	2.93E-6	ERG2	7	2.12E-5	0.08
2	SGTC_1666	st014829	4.04	29.0 µM	3.92E-6	calcium & mitochondrial duress	5	2.69E-5	0.20
3	SGTC_953	1188-0045	3.77	9.7 µM	1.52E-5	60S ribosome export	7	8.24E-5	0.09
4	SGTC_2808	7946468	3.70	45.5 µM	2.10E-5		7	1.07E-4	0.04
5	SGTC_584	0986-0246	3.50	15.4 µM	5.42E-5	heme requiring	30	2.35E-4	0.00
6	SGTC_1079	idarubicin	3.34	2.4 µM	1.08E-4	DNA damage response	11	4.13E-4	0.21
7	SGTC_2608	thymoquinone	3.30	42.7 µM	1.30E-4		9	4.84E-4	0.10
8	SGTC_1370	2001-0092	3.17	44.6 µM	2.30E-4		11	7.73E-4	0.17
9	SGTC_1381	2324-0066	3.04	62.1 µM	3.83E-4		19	0.00118	0.02
10	SGTC_669	0108-0021	3.02	26.2 µM	4.12E-4	fatty acid desaturase (OLE1)	23	0.00125	0.05
11	SGTC_1153	4055-0057	2.99	267.0 µM	4.73E-4		22	0.00141	0.05
12	SGTC_2573	2',4'-dihydroxychalcone	2.93	15.0 µM	5.98E-4		23	0.00171	0.02
13	SGTC_891	0929-0073	2.92	133.0 µM	6.10E-4		14	0.00173	0.01
14	SGTC_519	k048-0011	2.90	62.8 µM	6.78E-4		23	0.00189	0.02
15	SGTC_1737	st035557	2.83	69.7 µM	8.78E-4		22	0.00235	0.08
16	SGTC_1714	st033236	2.78	13.6 µM	0.00106		22	0.00275	6.45E-4
17	SGTC_2577	2',4'-dihydroxy-4-methoxychalcone	2.75	15.3 µM	0.00117		18	0.00298	0.03
18	SGTC_2289	7946404	2.74	165.1 µM	0.00122		41	0.00309	0.07
19	SGTC_1296	1068-0102	2.72	11.9 µM	0.00129		9	0.00323	0.00
20	SGTC_2616	abietic acid	2.70	100.0 µM	0.00138		15	0.00342	0.04

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.201	6.59E-32	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.161	5.96E-21	YKL066W_d	YKL066W_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.155	1.67E-19	YOR238W_p	YOR238W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.145	2.45E-17	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.144	5.84E-17	YBR090C_p	YBR090C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.142	1.57E-16	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.140	4.79E-16	YOR082C_d	YOR082C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.138	9.84E-16	YGL096W	TOS8	hom	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.134	6.19E-15	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.133	8.69E-15	YNL042W-B_p	YNL042W-B_p	hom	Putative protein of unknown function
0.133	9.21E-15	YNR039C	ZRG17	hom	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.129	7.37E-14	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.128	1.00E-13	YCL076W_d	YCL076W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.126	2.22E-13	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.123	8.85E-13	YDR232W	HEM1	het	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p