YEL034W / HYP2

Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YEL034W / HYP2

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.65|P-value:2.82E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:6.06|P-value:5.51E-7 ID:SGTC_26|Compound:0302-0163|FD-Score:5.92|P-value:9.79E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:6.92E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:8.30|P-value:1.27E-11 ID:SGTC_69|Compound:0096-0274|FD-Score:13.90|P-value:3.99E-29 ID:SGTC_86|Compound:0417-1630|FD-Score:5.35|P-value:8.58E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:9.49E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.74|P-value:7.13E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:11.70|P-value:2.39E-21 ID:SGTC_123|Compound:0083-0120|FD-Score:3.89|P-value:8.79E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.92|P-value:8.15E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.06|P-value:5.52E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.14|P-value:4.39E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.27|P-value:2.96E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.14|P-value:3.94E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:6.11|P-value:4.53E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:9.36|P-value:2.70E-14 ID:SGTC_586|Compound:0957-0265|FD-Score:9.18|P-value:8.16E-14 ID:SGTC_602|Compound:3130-1533|FD-Score:4.37|P-value:2.17E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.87|P-value:9.35E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.15|P-value:4.24E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:12.50|P-value:3.76E-24 ID:SGTC_839|Compound:0122-0028|FD-Score:4.61|P-value:1.05E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:9.40|P-value:2.10E-14 ID:SGTC_849|Compound:0386-0493|FD-Score:4.27|P-value:2.97E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.25|P-value:2.55E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:6.83|P-value:1.99E-8 ID:SGTC_858|Compound:0438-0351|FD-Score:4.03|P-value:5.99E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.88|P-value:9.05E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.65|P-value:2.72E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.67|P-value:8.73E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.55|P-value:1.31E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.26|P-value:2.40E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.83|P-value:5.16E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:26.90|P-value:1.28E-103 ID:SGTC_1103|Compound:duloxetine|FD-Score:9.85|P-value:1.21E-15 ID:SGTC_1109|Compound:tnp00067|FD-Score:-4.22|P-value:3.48E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:13.30|P-value:8.05E-27 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.25|P-value:3.19E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.33|P-value:2.51E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.05|P-value:5.61E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:3.71E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.97|P-value:3.19E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.79|P-value:6.08E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.87|P-value:1.17E-6 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.94|P-value:3.52E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:6.10|P-value:4.63E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.92|P-value:8.14E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.92|P-value:8.18E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.01|P-value:6.25E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:5.56E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.52|P-value:4.59E-6 ID:SGTC_1723|Compound:st034307|FD-Score:5.94|P-value:8.99E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-5.03|P-value:2.70E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.36|P-value:2.28E-4 ID:SGTC_1831|Compound:st055328|FD-Score:7.37|P-value:1.53E-9 ID:SGTC_1843|Compound:st055809|FD-Score:4.77|P-value:6.32E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.97|P-value:7.09E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.65|P-value:9.12E-5 ID:SGTC_2001|Compound:4023502|FD-Score:4.08|P-value:5.15E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.90|P-value:1.44E-8 ID:SGTC_2006|Compound:4011487|FD-Score:3.87|P-value:9.29E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.05|P-value:5.60E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-7.44|P-value:1.15E-9 ID:SGTC_2052|Compound:5265182|FD-Score:4.32|P-value:2.56E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:13.00|P-value:8.69E-26 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.49|P-value:1.58E-4 ID:SGTC_2225|Compound:6654152|FD-Score:11.80|P-value:1.74E-21 ID:SGTC_2239|Compound:6685329|FD-Score:5.08|P-value:2.19E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.78|P-value:1.67E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-5.12|P-value:2.00E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.22|P-value:3.50E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.70|P-value:7.95E-5 ID:SGTC_2312|Compound:7706453|FD-Score:4.09|P-value:5.03E-4 ID:SGTC_2326|Compound:6164455|FD-Score:7.85|P-value:1.37E-10 ID:SGTC_2344|Compound:7990960|FD-Score:13.50|P-value:1.09E-27 ID:SGTC_2397|Compound:5161689|FD-Score:-3.92|P-value:8.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.39|P-value:2.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:1.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.66|P-value:8.80E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:6.31|P-value:1.93E-7 ID:SGTC_2534|Compound:helenine|FD-Score:4.02|P-value:6.08E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.35|P-value:2.33E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.49|P-value:5.15E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.37|P-value:2.17E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.77|P-value:6.29E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:6.72|P-value:3.23E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.50|P-value:1.48E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.94|P-value:8.81E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.71|P-value:7.51E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.53|P-value:1.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.28|P-value:2.91E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.62|P-value:5.19E-8 ID:SGTC_3055|Compound:9094636|FD-Score:3.96|P-value:7.24E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.07|P-value:5.26E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.20|P-value:3.78E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:5.65|P-value:2.82E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:6.06|P-value:5.51E-7 ID:SGTC_26|Compound:0302-0163|FD-Score:5.92|P-value:9.79E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:6.92E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:8.30|P-value:1.27E-11 ID:SGTC_69|Compound:0096-0274|FD-Score:13.90|P-value:3.99E-29 ID:SGTC_86|Compound:0417-1630|FD-Score:5.35|P-value:8.58E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:9.49E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.74|P-value:7.13E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:11.70|P-value:2.39E-21 ID:SGTC_123|Compound:0083-0120|FD-Score:3.89|P-value:8.79E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.92|P-value:8.15E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:4.06|P-value:5.52E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.14|P-value:4.39E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.27|P-value:2.96E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.14|P-value:3.94E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:6.11|P-value:4.53E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:9.36|P-value:2.70E-14 ID:SGTC_586|Compound:0957-0265|FD-Score:9.18|P-value:8.16E-14 ID:SGTC_602|Compound:3130-1533|FD-Score:4.37|P-value:2.17E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.87|P-value:9.35E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.15|P-value:4.24E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:12.50|P-value:3.76E-24 ID:SGTC_839|Compound:0122-0028|FD-Score:4.61|P-value:1.05E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:9.40|P-value:2.10E-14 ID:SGTC_849|Compound:0386-0493|FD-Score:4.27|P-value:2.97E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:6.25|P-value:2.55E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:6.83|P-value:1.99E-8 ID:SGTC_858|Compound:0438-0351|FD-Score:4.03|P-value:5.99E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.88|P-value:9.05E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.65|P-value:2.72E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.67|P-value:8.73E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.55|P-value:1.31E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.26|P-value:2.40E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.83|P-value:5.16E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:26.90|P-value:1.28E-103 ID:SGTC_1103|Compound:duloxetine|FD-Score:9.85|P-value:1.21E-15 ID:SGTC_1109|Compound:tnp00067|FD-Score:-4.22|P-value:3.48E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:13.30|P-value:8.05E-27 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.25|P-value:3.19E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.33|P-value:2.51E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.05|P-value:5.61E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:3.71E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.97|P-value:3.19E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.79|P-value:6.08E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.87|P-value:1.17E-6 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.94|P-value:3.52E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:6.10|P-value:4.63E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.92|P-value:8.14E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.92|P-value:8.18E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.01|P-value:6.25E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:5.56E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.52|P-value:4.59E-6 ID:SGTC_1723|Compound:st034307|FD-Score:5.94|P-value:8.99E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-5.03|P-value:2.70E-5 ID:SGTC_1773|Compound:st048542|FD-Score:4.36|P-value:2.28E-4 ID:SGTC_1831|Compound:st055328|FD-Score:7.37|P-value:1.53E-9 ID:SGTC_1843|Compound:st055809|FD-Score:4.77|P-value:6.32E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.97|P-value:7.09E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.65|P-value:9.12E-5 ID:SGTC_2001|Compound:4023502|FD-Score:4.08|P-value:5.15E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.90|P-value:1.44E-8 ID:SGTC_2006|Compound:4011487|FD-Score:3.87|P-value:9.29E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.05|P-value:5.60E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-7.44|P-value:1.15E-9 ID:SGTC_2052|Compound:5265182|FD-Score:4.32|P-value:2.56E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:13.00|P-value:8.69E-26 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.49|P-value:1.58E-4 ID:SGTC_2225|Compound:6654152|FD-Score:11.80|P-value:1.74E-21 ID:SGTC_2239|Compound:6685329|FD-Score:5.08|P-value:2.19E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.78|P-value:1.67E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-5.12|P-value:2.00E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.22|P-value:3.50E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.70|P-value:7.95E-5 ID:SGTC_2312|Compound:7706453|FD-Score:4.09|P-value:5.03E-4 ID:SGTC_2326|Compound:6164455|FD-Score:7.85|P-value:1.37E-10 ID:SGTC_2344|Compound:7990960|FD-Score:13.50|P-value:1.09E-27 ID:SGTC_2397|Compound:5161689|FD-Score:-3.92|P-value:8.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.39|P-value:2.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:1.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.66|P-value:8.80E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:6.31|P-value:1.93E-7 ID:SGTC_2534|Compound:helenine|FD-Score:4.02|P-value:6.08E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.35|P-value:2.33E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.49|P-value:5.15E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.37|P-value:2.17E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.77|P-value:6.29E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:6.72|P-value:3.23E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.50|P-value:1.48E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.94|P-value:8.81E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.71|P-value:7.51E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.53|P-value:1.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.28|P-value:2.91E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.62|P-value:5.19E-8 ID:SGTC_3055|Compound:9094636|FD-Score:3.96|P-value:7.24E-4 ID:SGTC_3101|Compound:9120531|FD-Score:4.07|P-value:5.26E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.20|P-value:3.78E-4

Top fitness defect scores for YEL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1098 clofazimine 26.90 15.1 µM 1.28E-103 heme biosynthesis & mitochondrial translocase 1 3.53E-159 14.80
2 SGTC_69 0096-0274 13.90 206.7 µM 3.99E-29 mitochondrial processes 1 5.53E-44 1.83
3 SGTC_2344 7990960 13.50 77.0 µM 1.09E-27 3 9.18E-42 0.91
4 SGTC_1113 artemisinin 13.30 1.2 µM 8.05E-27 heme biosynthesis & mitochondrial translocase 4 2.00E-40 4.38
5 SGTC_2129 girgensonine 13.00 121.0 µM 8.69E-26 heme biosynthesis & mitochondrial translocase 2 7.87E-39 2.17
6 SGTC_745 0469-0705 12.50 296.0 µM 3.76E-24 mitochondrial processes 1 2.63E-36 2.36
7 SGTC_2225 6654152 11.80 15.4 µM 1.74E-21 6 3.40E-32 0.15
8 SGTC_120 rhodamine 6G 11.70 52.3 µM 2.39E-21 mitochondrial processes 1 5.54E-32 3.36
9 SGTC_1103 duloxetine 9.85 36.1 µM 1.21E-15 1 3.44E-23 4.74
10 SGTC_842 0271-0008 9.40 11.1 µM 2.10E-14 heme biosynthesis & mitochondrial translocase 4 2.78E-21 2.88
11 SGTC_576 1073-0113 9.36 22.7 µM 2.70E-14 redox potentiating 6 4.09E-21 0.48
12 SGTC_586 0957-0265 9.18 8.2 µM 8.16E-14 cell wall 9 2.25E-20 0.12
13 SGTC_64 000l-0018 8.30 272.1 µM 1.27E-11 ubiquinone biosynthesis & proteasome 17 5.26E-17 0.22
14 SGTC_2326 6164455 7.85 177.6 µM 1.37E-10 mitochondrial processes 2 2.05E-15 1.79
15 SGTC_1831 st055328 7.37 12.0 µM 1.53E-9 heme biosynthesis & mitochondrial translocase 4 8.31E-14 0.19
16 SGTC_2004 4023728 6.90 41.9 µM 1.44E-8 13 2.57E-12 0.21
17 SGTC_853 0419-0306 6.83 21.0 µM 1.99E-8 2 4.24E-12 1.93
18 SGTC_2626 ethyl orsellinate 6.72 100.0 µM 3.23E-8 2 8.89E-12 1.25
19 SGTC_3037 9091026 6.62 49.5 µM 5.19E-8 NEO1-PIK1 10 1.84E-11 0.56
20 SGTC_2510 benzyl isothiocyanate 6.31 8.3 µM 1.93E-7 7 1.37E-10 0.34

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.333 2.44E-87 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.332 5.55E-87 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.312 7.49E-77 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.286 5.06E-64 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.272 4.40E-58 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.268 5.31E-56 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.263 3.99E-54 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.256 5.81E-51 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.245 5.22E-47 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
0.235 1.98E-43 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.226 3.24E-40 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.226 4.80E-40 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.215 2.32E-36 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.212 2.02E-35 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.199 2.60E-31 YIL075C RPN2 het Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress