YEL042W / GDA1

Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL042W / GDA1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:5.53E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:7.36|P-value:1.18E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:3.30|P-value:3.17E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.22|P-value:6.33E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.04|P-value:8.27E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.37|P-value:2.47E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.28|P-value:4.25E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.44|P-value:1.71E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.68|P-value:6.35E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.55|P-value:1.10E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.02|P-value:9.02E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.70|P-value:6.36E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.69|P-value:2.14E-12 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.47|P-value:1.66E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.31|P-value:4.13E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.80|P-value:4.16E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.26|P-value:5.28E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.56|P-value:1.15E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.06|P-value:1.79E-10 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.08|P-value:6.70E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.21|P-value:4.58E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:7.57|P-value:2.25E-15 ID:SGTC_825|Compound:1988-2224|FD-Score:6.47|P-value:1.01E-11 ID:SGTC_833|Compound:3852-0053|FD-Score:4.85|P-value:2.64E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.04|P-value:8.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.14|P-value:9.16E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.12|P-value:6.38E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.09|P-value:7.11E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.60|P-value:9.69E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.76|P-value:5.12E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.32|P-value:3.02E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.08|P-value:6.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.36|P-value:2.28E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.15|P-value:5.74E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.35|P-value:2.66E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.07|P-value:6.81E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.73|P-value:4.92E-7 ID:SGTC_1948|Compound:st076329|FD-Score:3.06|P-value:7.87E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.04|P-value:7.65E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.00|P-value:9.66E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.62|P-value:9.08E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.96|P-value:2.76E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-4.79|P-value:3.13E-7 ID:SGTC_2041|Compound:5107442|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.23|P-value:3.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.47|P-value:4.94E-15 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.24|P-value:2.93E-8 ID:SGTC_2678|Compound:equilin|FD-Score:3.68|P-value:7.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.83|P-value:7.62E-13 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.52|P-value:1.37E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.19|P-value:4.48E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_2915|Compound:7971052|FD-Score:4.30|P-value:4.36E-6 ID:SGTC_2953|Compound:9074162|FD-Score:4.39|P-value:2.78E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.11|P-value:6.42E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.70|P-value:6.58E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.16|P-value:5.38E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.53|P-value:1.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.74|P-value:5.53E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:7.36|P-value:1.18E-14 ID:SGTC_117|Compound:lucigenin|FD-Score:3.30|P-value:3.17E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.22|P-value:6.33E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.04|P-value:8.27E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.37|P-value:2.47E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-4.28|P-value:4.25E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.44|P-value:1.71E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.68|P-value:6.35E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.55|P-value:1.10E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.02|P-value:9.02E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.70|P-value:6.36E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.69|P-value:2.14E-12 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.47|P-value:1.66E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:4.31|P-value:4.13E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.80|P-value:4.16E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.26|P-value:5.28E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:3.56|P-value:1.15E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.06|P-value:1.79E-10 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.08|P-value:6.70E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.21|P-value:4.58E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:7.57|P-value:2.25E-15 ID:SGTC_825|Compound:1988-2224|FD-Score:6.47|P-value:1.01E-11 ID:SGTC_833|Compound:3852-0053|FD-Score:4.85|P-value:2.64E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:3.04|P-value:8.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.14|P-value:9.16E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.12|P-value:6.38E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.09|P-value:7.11E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.60|P-value:9.69E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.76|P-value:5.12E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.32|P-value:3.02E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.08|P-value:6.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.36|P-value:2.28E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.15|P-value:5.74E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.35|P-value:2.66E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.07|P-value:6.81E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.73|P-value:4.92E-7 ID:SGTC_1948|Compound:st076329|FD-Score:3.06|P-value:7.87E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.04|P-value:7.65E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.00|P-value:9.66E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.62|P-value:9.08E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.21|P-value:4.46E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.96|P-value:2.76E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-4.79|P-value:3.13E-7 ID:SGTC_2041|Compound:5107442|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.23|P-value:3.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.47|P-value:4.94E-15 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.24|P-value:2.93E-8 ID:SGTC_2678|Compound:equilin|FD-Score:3.68|P-value:7.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.83|P-value:7.62E-13 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.52|P-value:1.37E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.19|P-value:4.48E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_2915|Compound:7971052|FD-Score:4.30|P-value:4.36E-6 ID:SGTC_2953|Compound:9074162|FD-Score:4.39|P-value:2.78E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.11|P-value:6.42E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.70|P-value:6.58E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.16|P-value:5.38E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.53|P-value:1.32E-4

Top fitness defect scores for YEL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_819 1013-0258 7.57 27.7 µM 2.25E-15 15 1.91E-14
2 SGTC_2582 agaric acid 7.47 100.0 µM 4.94E-15 redox potentiating 115 3.99E-14
3 SGTC_70 0141-0289 7.36 43.3 µM 1.18E-14 mitochondrial stress 49 8.98E-14
4 SGTC_2688 kanamycin b 6.83 96.7 µM 7.62E-13 calcium & mitochondrial duress 113 4.35E-12
5 SGTC_453 enantio-paf c16 6.69 10.0 µM 2.14E-12 30 1.14E-11
6 SGTC_825 1988-2224 6.47 89.6 µM 1.01E-11 cell wall signaling 12 4.83E-11
7 SGTC_800 3448-7362 6.06 155.0 µM 1.79E-10 translation 46 7.02E-10
8 SGTC_2658 polymyxin b sulfate 5.24 77.0 µM 2.93E-8 NEO1 27 8.14E-8
9 SGTC_833 3852-0053 4.85 558.0 µM 2.64E-7 7 6.32E-7
10 SGTC_1939 st074455 4.73 53.6 µM 4.92E-7 15 1.13E-6
11 SGTC_2953 9074162 4.39 66.5 µM 2.78E-6 16 5.69E-6
12 SGTC_593 1203-0218 4.31 61.7 µM 4.13E-6 6 8.23E-6
13 SGTC_2915 7971052 4.30 15.2 µM 4.36E-6 3 8.67E-6
14 SGTC_625 k213-0058 4.26 121.0 µM 5.28E-6 translation 84 1.04E-5
15 SGTC_138 0850-0259 4.22 40.9 µM 6.33E-6 cell wall 181 1.23E-5
16 SGTC_999 4022-0066 4.14 22.7 µM 9.16E-6 Golgi 33 1.73E-5
17 SGTC_605 1315-0399 3.80 119.0 µM 4.16E-5 Golgi 28 7.13E-5
18 SGTC_1496 4469-0713 3.76 57.4 µM 5.12E-5 27 8.66E-5
19 SGTC_58 0957-0393 3.74 9.0 µM 5.53E-5 cell wall 398 9.30E-5
20 SGTC_435 c-PAF 3.70 6.7 µM 6.36E-5 55 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 1.89E-71 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.226 3.86E-40 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213 1.31E-35 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.207 1.20E-33 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.206 2.32E-33 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.190 1.32E-28 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.186 2.24E-27 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.185 3.20E-27 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.182 2.16E-26 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.176 7.94E-25 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.176 8.70E-25 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.173 4.65E-24 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.170 2.79E-23 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.170 3.64E-23 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.170 4.26E-23 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane