YEL044W / IES6

Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL044W / IES6

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:5.35|P-value:3.12E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.05|P-value:1.33E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.68|P-value:6.66E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.50|P-value:5.74E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:8.57E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.12|P-value:6.49E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.48|P-value:1.58E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.57|P-value:4.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.58|P-value:7.94E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:4.12|P-value:6.59E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.48|P-value:2.55E-19 ID:SGTC_360|Compound:0957-0399|FD-Score:4.09|P-value:7.25E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.02|P-value:9.37E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.55|P-value:5.03E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.35|P-value:2.62E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.63|P-value:3.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:9.16|P-value:6.31E-18 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:1.66E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.40|P-value:7.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.35|P-value:9.57E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.58|P-value:1.00E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:6.91|P-value:5.98E-11 ID:SGTC_951|Compound:1171-0579|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.73|P-value:2.71E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.26|P-value:2.72E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.80|P-value:1.65E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:7.86|P-value:1.16E-13 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.05|P-value:6.62E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.84|P-value:1.85E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.24|P-value:4.08E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.03|P-value:9.14E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.70|P-value:2.94E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.40|P-value:1.64E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.64|P-value:8.11E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-4.60|P-value:7.26E-6 ID:SGTC_1603|Compound:st002045|FD-Score:4.66|P-value:7.47E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.57|P-value:4.66E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.90|P-value:2.56E-6 ID:SGTC_1612|Compound:st002233|FD-Score:-3.32|P-value:8.37E-4 ID:SGTC_1622|Compound:st003707|FD-Score:8.51|P-value:1.02E-15 ID:SGTC_1750|Compound:st081859|FD-Score:7.54|P-value:1.01E-12 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.45|P-value:1.34E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.93|P-value:1.31E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.87|P-value:1.63E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.85|P-value:2.43E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.44|P-value:1.81E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.15|P-value:5.79E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:5.77|P-value:3.92E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.75|P-value:5.04E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.57|P-value:1.06E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.81|P-value:1.59E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.35|P-value:9.39E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.87|P-value:1.62E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.90|P-value:6.52E-11 ID:SGTC_2858|Compound:9025781|FD-Score:7.74|P-value:2.70E-13 ID:SGTC_2896|Compound:9052656|FD-Score:-5.32|P-value:2.65E-7 ID:SGTC_2912|Compound:7964298|FD-Score:9.54|P-value:2.69E-19 ID:SGTC_2949|Compound:9072542|FD-Score:4.03|P-value:9.09E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.41|P-value:7.73E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.32|P-value:3.00E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.35|P-value:7.77E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.70|P-value:2.94E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.01|P-value:1.59E-6 ID:SGTC_3285|Compound:9112818|FD-Score:4.93|P-value:2.30E-6 ID:SGTC_3289|Compound:9119912|FD-Score:-3.65|P-value:2.80E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.44|P-value:6.35E-19 ID:SGTC_3321|Compound:9137793|FD-Score:4.64|P-value:8.11E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.45|P-value:1.75E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.06|P-value:8.30E-9 ID:SGTC_3356|Compound:9151811|FD-Score:5.07|P-value:1.18E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:5.35|P-value:3.12E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.05|P-value:1.33E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.68|P-value:6.66E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.50|P-value:5.74E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:8.57E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.12|P-value:6.49E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.48|P-value:1.58E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.57|P-value:4.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.58|P-value:7.94E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:4.12|P-value:6.59E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.48|P-value:2.55E-19 ID:SGTC_360|Compound:0957-0399|FD-Score:4.09|P-value:7.25E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.34|P-value:9.69E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.02|P-value:9.37E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.55|P-value:5.03E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.35|P-value:2.62E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.63|P-value:3.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:9.16|P-value:6.31E-18 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:1.66E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.40|P-value:7.98E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.35|P-value:9.57E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.58|P-value:1.00E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:6.91|P-value:5.98E-11 ID:SGTC_951|Compound:1171-0579|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.73|P-value:2.71E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.26|P-value:2.72E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.80|P-value:1.65E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:7.86|P-value:1.16E-13 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.77|P-value:2.34E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.05|P-value:6.62E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.84|P-value:1.85E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.24|P-value:4.08E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.03|P-value:9.14E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.70|P-value:2.94E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.40|P-value:1.64E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:4.64|P-value:8.11E-6 ID:SGTC_1602|Compound:st001878|FD-Score:-4.60|P-value:7.26E-6 ID:SGTC_1603|Compound:st002045|FD-Score:4.66|P-value:7.47E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.57|P-value:4.66E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.90|P-value:2.56E-6 ID:SGTC_1612|Compound:st002233|FD-Score:-3.32|P-value:8.37E-4 ID:SGTC_1622|Compound:st003707|FD-Score:8.51|P-value:1.02E-15 ID:SGTC_1750|Compound:st081859|FD-Score:7.54|P-value:1.01E-12 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.45|P-value:1.34E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.37|P-value:7.17E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.93|P-value:1.31E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.87|P-value:1.63E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.85|P-value:2.43E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.44|P-value:1.81E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.15|P-value:5.79E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:5.77|P-value:3.92E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.75|P-value:5.04E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.57|P-value:1.06E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.81|P-value:1.59E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.35|P-value:9.39E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.87|P-value:1.62E-4 ID:SGTC_2853|Compound:9015042|FD-Score:6.90|P-value:6.52E-11 ID:SGTC_2858|Compound:9025781|FD-Score:7.74|P-value:2.70E-13 ID:SGTC_2896|Compound:9052656|FD-Score:-5.32|P-value:2.65E-7 ID:SGTC_2912|Compound:7964298|FD-Score:9.54|P-value:2.69E-19 ID:SGTC_2949|Compound:9072542|FD-Score:4.03|P-value:9.09E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.41|P-value:7.73E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.32|P-value:3.00E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.35|P-value:7.77E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.70|P-value:2.94E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.01|P-value:1.59E-6 ID:SGTC_3285|Compound:9112818|FD-Score:4.93|P-value:2.30E-6 ID:SGTC_3289|Compound:9119912|FD-Score:-3.65|P-value:2.80E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.44|P-value:6.35E-19 ID:SGTC_3321|Compound:9137793|FD-Score:4.64|P-value:8.11E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.45|P-value:1.75E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.06|P-value:8.30E-9 ID:SGTC_3356|Compound:9151811|FD-Score:5.07|P-value:1.18E-6

Top fitness defect scores for YEL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2912 7964298 9.54 10.9 µM 2.69E-19 cell wall 18 7.09E-22
2 SGTC_3311 9131146 9.44 2.9 µM 6.35E-19 cell wall 19 1.89E-21
3 SGTC_800 3448-7362 9.16 155.0 µM 6.31E-18 translation 11 2.61E-20
4 SGTC_1622 st003707 8.51 19.4 µM 1.02E-15 calcium & mitochondrial duress 8 8.72E-18
5 SGTC_1006 4099-6547 7.86 255.0 µM 1.16E-13 1 1.94E-15
6 SGTC_2858 9025781 7.74 9.0 µM 2.70E-13 sphingolipid biosynthesis & PDR1 29 5.10E-15
7 SGTC_1750 st081859 7.54 2.4 µM 1.01E-12 endomembrane recycling 78 2.30E-14
8 SGTC_928 2764-0428 6.91 58.7 µM 5.98E-11 cell wall 10 2.43E-12
9 SGTC_2853 9015042 6.90 58.4 µM 6.52E-11 1 2.69E-12
10 SGTC_994 3910-0338 6.26 138.0 µM 2.72E-9 calcium & mitochondrial duress 12 1.91E-10
11 SGTC_3350 9150499 6.06 3.6 µM 8.30E-9 cell wall 13 6.82E-10
12 SGTC_2507 purpurin 5.77 79.7 µM 3.92E-8 copper-dependent oxidative stress 15 4.02E-9
13 SGTC_863 0466-0191 5.58 129.0 µM 1.00E-7 cell wall 33 1.17E-8
14 SGTC_108 0509-0257 5.35 621.1 µM 3.12E-7 18 4.29E-8
15 SGTC_3356 9151811 5.07 4.5 µM 1.18E-6 cell wall 9 1.96E-7
16 SGTC_138 0850-0259 5.05 40.9 µM 1.33E-6 cell wall 143 2.24E-7
17 SGTC_3266 9136860 5.01 49.5 µM 1.59E-6 cell wall 28 2.76E-7
18 SGTC_3285 9112818 4.93 20.9 µM 2.30E-6 cell wall 18 4.19E-7
19 SGTC_1610 st001799 4.90 48.1 µM 2.56E-6 3 4.75E-7
20 SGTC_2540 epiandrosterone 4.75 100.0 µM 5.04E-6 37 1.03E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.302 1.33E-71 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.267 7.02E-56 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.262 1.48E-53 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.255 7.57E-51 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.237 6.50E-44 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.233 1.50E-42 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.229 5.90E-41 YNL059C ARP5 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.228 6.83E-41 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.225 1.17E-39 YML128C MSC1 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
0.220 6.60E-38 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.217 6.62E-37 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.213 9.33E-36 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.211 3.33E-35 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.205 4.04E-33 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.201 6.95E-32 YLR371W ROM2 hom GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p