YEL049W / PAU2

Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL049W / PAU2

Click on Significant Values for Screen Details ID:SGTC_531|Compound:3788-1495|FD-Score:-3.11|P-value:3.47E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.64|P-value:3.50E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:2.04E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.78|P-value:9.73E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.85|P-value:7.62E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.14|P-value:2.44E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.81|P-value:8.66E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.93|P-value:6.91E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.14|P-value:3.14E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.87|P-value:8.89E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.42|P-value:6.60E-7 ID:SGTC_2314|Compound:7727897|FD-Score:-3.92|P-value:9.08E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.77|P-value:8.79E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.90|P-value:6.20E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.80|P-value:9.10E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.78|P-value:9.82E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.11|P-value:3.47E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.64|P-value:3.50E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.25|P-value:1.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:2.04E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.78|P-value:9.73E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.85|P-value:7.62E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.14|P-value:2.44E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.81|P-value:8.66E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.93|P-value:6.91E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.14|P-value:3.14E-4 ID:SGTC_1739|Compound:st037196|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.87|P-value:8.89E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.42|P-value:6.60E-7 ID:SGTC_2314|Compound:7727897|FD-Score:-3.92|P-value:9.08E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.77|P-value:8.79E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.90|P-value:6.20E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.80|P-value:9.10E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.78|P-value:9.82E-4

Top fitness defect scores for YEL049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1286 0929-0070 3.14 131.0 µM 2.44E-4 53 8.58E-4
2 SGTC_1739 st037196 2.96 92.5 µM 5.04E-4 69 0.00156
3 SGTC_2753 fluvastatin 2.90 17.1 µM 6.20E-4 azole & statin 84 0.00186
4 SGTC_1271 0832-2808 2.85 169.0 µM 7.62E-4 60 0.00220
5 SGTC_1291 0993-0025 2.81 5.8 µM 8.66E-4 47 0.00245
6 SGTC_2970 9090938 2.80 41.9 µM 9.10E-4 RNA processing & uracil transport 129 0.00255
7 SGTC_1270 0831-1170 2.78 17.3 µM 9.73E-4 66 0.00270
8 SGTC_2973 9094665 2.78 18.0 µM 9.82E-4 NEO1 102 0.00272
9 SGTC_1758 st042942 2.77 75.2 µM 0.00100 69 0.00277
10 SGTC_39 0986-0283 2.77 58.4 µM 0.00102 calcium & mitochondrial duress 107 0.00280
11 SGTC_1246 0422-0085 2.76 105.0 µM 0.00106 107 0.00289
12 SGTC_2004 4023728 2.70 41.9 µM 0.00130 108 0.00344
13 SGTC_1748 st037455 2.63 53.6 µM 0.00168 121 0.00423
14 SGTC_376 3970-0862 2.61 59.1 µM 0.00183 99 0.00455
15 SGTC_1579 chlormadinone acetate 2.58 49.4 µM 0.00202 84 0.00495
16 SGTC_822 1487-0950 2.56 154.0 µM 0.00219 89 0.00528
17 SGTC_2986 9022445 2.46 71.4 µM 0.00302 123 0.00690
18 SGTC_780 0109-0199 2.44 192.0 µM 0.00325 135 0.00734
19 SGTC_2792 7535235 2.44 81.8 µM 0.00326 fatty acid desaturase (OLE1) 130 0.00735
20 SGTC_807 1315-0151 2.42 48.0 µM 0.00348 148 0.00777

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.400 1.81E-129 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.366 5.90E-107 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.314 1.88E-77 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.298 1.57E-69 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.285 7.61E-64 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.275 2.72E-59 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.258 3.49E-52 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.250 8.13E-49 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.244 8.38E-47 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.243 3.35E-46 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.242 9.10E-46 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.234 3.68E-43 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.232 3.59E-42 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.227 1.70E-40 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.224 1.70E-39 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants