HIPHOP chemogenomics database

YEL053C / MAK10

Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible

Zygosity: Homozygous strain

fixedexpanded
Profile for YEL053C / MAK10

Click on Significant Values for Screen Details

Top fitness defect scores for YEL053C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_98	0074-0023	9.68	107.7 µM	4.27E-24	Golgi	3	1.77E-22
2	SGTC_528	3492-0019	7.60	172.0 µM	1.51E-15	calcium & mitochondrial duress	85	1.49E-14
3	SGTC_188	3229-0966	5.56	278.5 µM	4.03E-9		13	1.37E-8
4	SGTC_124	0136-0217	5.53	7.1 µM	4.84E-9	mitochondrial stress	27	1.63E-8
5	SGTC_2642	cholecalciferol	5.10	100.0 µM	5.93E-8		14	1.67E-7
6	SGTC_2737	bleomycin	4.80	30.5 nM	3.13E-7	Golgi	63	7.82E-7
7	SGTC_3308	9128332	4.51	17.6 µM	1.45E-6	plasma membrane duress	60	3.25E-6
8	SGTC_2954	9074818	4.49	52.7 µM	1.63E-6		25	3.63E-6
9	SGTC_2314	7727897	4.37	200.0 µM	2.86E-6		12	6.12E-6
10	SGTC_3118	9124250	4.15	49.5 µM	8.47E-6		11	1.68E-5
11	SGTC_337	1315-0038	4.15	354.0 µM	8.50E-6	amide catabolism	25	1.68E-5
12	SGTC_748	0136-0228	4.11	77.9 µM	9.96E-6	redox potentiating	73	1.95E-5
13	SGTC_2989	9073649	4.06	71.4 µM	1.29E-5		34	2.48E-5
14	SGTC_1687	st020778	4.03	55.4 µM	1.49E-5		171	2.83E-5
15	SGTC_2651	1327-0036	3.87	5.0 µM	2.98E-5		164	5.42E-5
16	SGTC_1679	4130-1276	3.83	6.7 µM	3.58E-5	Golgi	69	6.42E-5
17	SGTC_878	0828-0289	3.79	13.7 µM	4.22E-5		53	7.49E-5
18	SGTC_2474	5321570	3.79	43.3 µM	4.26E-5		17	7.54E-5
19	SGTC_2363	9053361	3.76	176.0 µM	4.75E-5	Golgi	35	8.36E-5
20	SGTC_2994	9053520	3.65	71.4 µM	7.72E-5	RPP1 & pyrimidine depletion	34	1.31E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.266	1.56E-55	YJL004C	SYS1	hom	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.234	4.64E-43	YPL051W	ARL3	hom	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.206	1.71E-33	YPR050C_d	YPR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.200	1.74E-31	YBR164C	ARL1	hom	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.182	2.78E-26	YOR036W	PEP12	hom	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.180	9.11E-26	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.173	6.34E-24	YOR109W	INP53	hom	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.167	1.64E-22	YOR068C	VAM10	hom	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.167	2.22E-22	YDR093W	DNF2	hom	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.159	2.46E-20	YDL192W	ARF1	hom	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.158	3.25E-20	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152	9.27E-19	YJL164C	TPK1	hom	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.148	7.27E-18	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.145	2.93E-17	YDR495C	VPS3	hom	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.143	6.56E-17	YJL024C	APS3	hom	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress