YEL059C-A / SOM1

Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL059C-A / SOM1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.90|P-value:3.07E-31 ID:SGTC_146|Compound:3448-8650|FD-Score:3.21|P-value:3.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.50|P-value:2.52E-95 ID:SGTC_386|Compound:1509-0011|FD-Score:12.70|P-value:8.29E-42 ID:SGTC_413|Compound:propylparaben|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.45|P-value:1.24E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.54|P-value:7.56E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:2.96|P-value:8.51E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.29|P-value:2.78E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.90|P-value:1.80E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.05|P-value:6.16E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.50|P-value:1.06E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.95|P-value:1.44E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.03|P-value:6.73E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.59|P-value:7.31E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.34|P-value:2.10E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.19|P-value:3.70E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.85|P-value:2.24E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.41|P-value:1.55E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.09|P-value:7.39E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.50|P-value:1.40E-173 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.20|P-value:4.36E-6 ID:SGTC_1990|Compound:st072050|FD-Score:4.65|P-value:4.11E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.08|P-value:5.53E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.94|P-value:9.43E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.10|P-value:6.91E-6 ID:SGTC_2957|Compound:9076800|FD-Score:2.98|P-value:7.85E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.64|P-value:5.66E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.33|P-value:2.13E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.73|P-value:2.68E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.71|P-value:3.03E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.90|P-value:3.07E-31 ID:SGTC_146|Compound:3448-8650|FD-Score:3.21|P-value:3.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.50|P-value:2.52E-95 ID:SGTC_386|Compound:1509-0011|FD-Score:12.70|P-value:8.29E-42 ID:SGTC_413|Compound:propylparaben|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.45|P-value:1.24E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.54|P-value:7.56E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:2.96|P-value:8.51E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.29|P-value:2.78E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.90|P-value:1.80E-5 ID:SGTC_877|Compound:0771-0151|FD-Score:3.43|P-value:1.38E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.05|P-value:6.16E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.50|P-value:1.06E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.95|P-value:1.44E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.03|P-value:6.73E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.59|P-value:7.31E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.34|P-value:2.10E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.19|P-value:3.70E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.85|P-value:2.24E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.41|P-value:1.55E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.09|P-value:7.39E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.50|P-value:1.40E-173 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-4.20|P-value:4.36E-6 ID:SGTC_1990|Compound:st072050|FD-Score:4.65|P-value:4.11E-7 ID:SGTC_2161|Compound:5662504|FD-Score:3.08|P-value:5.53E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.94|P-value:9.43E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.10|P-value:6.91E-6 ID:SGTC_2957|Compound:9076800|FD-Score:2.98|P-value:7.85E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.64|P-value:5.66E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.33|P-value:2.13E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.73|P-value:2.68E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.71|P-value:3.03E-7

Top fitness defect scores for YEL059C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 26.50 42.4 µM 1.40E-173 12 5.38E-155
2 SGTC_236 1509-0011 19.50 5.3 µM 2.52E-95 58 3.23E-85
3 SGTC_386 1509-0011 12.70 3.1 µM 8.29E-42 31 1.73E-37
4 SGTC_134 0269-0018 10.90 6.9 µM 3.07E-31 35 4.64E-28
5 SGTC_3201 9113999 4.73 49.5 µM 2.68E-7 18 1.11E-6
6 SGTC_1990 st072050 4.65 59.8 µM 4.11E-7 7 1.63E-6
7 SGTC_432 NS 1619 4.45 61.3 µM 1.24E-6 18 4.38E-6
8 SGTC_1094 duloxetine 4.34 25.4 µM 2.10E-6 RPP1 & pyrimidine depletion 9 7.01E-6
9 SGTC_2926 9010726 4.10 65.2 µM 6.91E-6 30 2.04E-5
10 SGTC_1380 2291-0730 4.09 164.0 µM 7.39E-6 21 2.16E-5
11 SGTC_1888 azatryptophan 4.00 97.5 µM 1.12E-5 13 3.13E-5
12 SGTC_981 1488-1094 3.95 54.9 µM 1.44E-5 22 3.93E-5
13 SGTC_874 0599-0792 3.90 117.0 µM 1.80E-5 29 4.80E-5
14 SGTC_1307 1187-1599 3.85 12.2 µM 2.24E-5 PDR1 13 5.83E-5
15 SGTC_3153 9100258 3.64 49.5 µM 5.66E-5 32 1.34E-4
16 SGTC_810 3825-7150 3.48 143.0 µM 1.13E-4 60S ribosome export 16 2.49E-4
17 SGTC_1200 1643-0193 3.48 18.4 µM 1.14E-4 29 2.52E-4
18 SGTC_806 3966-4455 3.46 5.9 µM 1.22E-4 40 2.67E-4
19 SGTC_413 propylparaben 3.45 100.0 µM 1.27E-4 amide catabolism 36 2.78E-4
20 SGTC_1982 st072467 3.45 71.9 µM 1.29E-4 58 2.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.788 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.741 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.739 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.729 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.719 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.712 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.702 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.686 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.662 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.661 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.648 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.646 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.646 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.646 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.640 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain