HIPHOP chemogenomics database
YEL065W / SIT1 
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YEL065W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.156 | 9.26E-20 | YOL130W | ALR1 | het | Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions |
| 0.130 | 3.59E-14 | YML131W | YML131W | hom | Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
| 0.110 | 1.72E-10 | YPR170C_d | YPR170C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B |
| 0.107 | 4.82E-10 | YML050W | AIM32 | hom | Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
| 0.104 | 1.78E-9 | YDL091C | UBX3 | hom | Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10 |
| 0.101 | 5.07E-9 | YDR370C | DXO1 | hom | Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p |
| 0.100 | 7.38E-9 | YAL040C | CLN3 | hom | G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis |
| 0.098 | 1.70E-8 | YMR088C | VBA1 | hom | Permease of basic amino acids in the vacuolar membrane |
| 0.095 | 3.82E-8 | YJL010C | NOP9 | het | Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain |
| 0.094 | 5.24E-8 | YNR061C | YNR061C | hom | Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress |
| 0.093 | 6.00E-8 | YER153C | PET122 | hom | Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane |
| 0.093 | 6.47E-8 | YDR089W | YDR089W | hom | Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress |
| 0.091 | 1.46E-7 | YKL173W | SNU114 | het | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 |
| 0.090 | 1.62E-7 | YKR092C | SRP40 | hom | Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
| 0.089 | 2.21E-7 | YGL007W_d | BRP1_d | hom | Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 |