YEL065W / SIT1

Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL065W / SIT1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:2.86|P-value:6.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.82|P-value:7.15E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.79|P-value:8.49E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.28|P-value:1.05E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-2.78|P-value:8.40E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.78|P-value:1.02E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.94|P-value:4.59E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.82|P-value:7.04E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.51|P-value:3.72E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.35|P-value:8.07E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:2.87|P-value:6.05E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:2.94|P-value:4.61E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:2.94|P-value:4.56E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.30|P-value:9.22E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.87|P-value:5.76E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.87|P-value:6.18E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.44|P-value:5.28E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:2.81|P-value:7.59E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.80|P-value:8.18E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.07|P-value:2.61E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.02|P-value:3.13E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-2.83|P-value:6.71E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-2.94|P-value:4.32E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-2.97|P-value:3.92E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.02|P-value:3.17E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.82|P-value:2.58E-11 ID:SGTC_1925|Compound:st057770|FD-Score:2.76|P-value:9.24E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.21|P-value:2.10E-9 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.65|P-value:1.80E-5 ID:SGTC_2179|Compound:6298986|FD-Score:2.93|P-value:4.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:2.88|P-value:5.92E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.64|P-value:1.99E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-2.78|P-value:8.33E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.17|P-value:1.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.74|P-value:9.53E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.50|P-value:3.70E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.10|P-value:2.37E-4 ID:SGTC_3045|Compound:9092950|FD-Score:2.95|P-value:4.42E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-2.79|P-value:8.00E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.13|P-value:1.63E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.12|P-value:2.22E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.84|P-value:6.77E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:2.86|P-value:6.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.82|P-value:7.15E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:2.79|P-value:8.49E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.28|P-value:1.05E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-2.78|P-value:8.40E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.78|P-value:1.02E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:2.94|P-value:4.59E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.82|P-value:7.04E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.51|P-value:3.72E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.35|P-value:8.07E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:2.87|P-value:6.05E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:2.94|P-value:4.61E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:2.94|P-value:4.56E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.30|P-value:9.22E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.87|P-value:5.76E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.87|P-value:6.18E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.44|P-value:5.28E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:2.81|P-value:7.59E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.80|P-value:8.18E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.07|P-value:2.61E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.02|P-value:3.13E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-2.83|P-value:6.71E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-2.94|P-value:4.32E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-2.97|P-value:3.92E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.02|P-value:3.17E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.82|P-value:2.58E-11 ID:SGTC_1925|Compound:st057770|FD-Score:2.76|P-value:9.24E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.21|P-value:2.10E-9 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.65|P-value:1.80E-5 ID:SGTC_2179|Compound:6298986|FD-Score:2.93|P-value:4.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:2.88|P-value:5.92E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.64|P-value:1.99E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-2.78|P-value:8.33E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.17|P-value:1.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.74|P-value:9.53E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.50|P-value:3.70E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.10|P-value:2.37E-4 ID:SGTC_3045|Compound:9092950|FD-Score:2.95|P-value:4.42E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-2.79|P-value:8.00E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.13|P-value:1.63E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.12|P-value:2.22E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.84|P-value:6.77E-4

Top fitness defect scores for YEL065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1921 5740136 5.82 50.0 µM 2.58E-11 TRP & mitochondrial translation 17 2.93E-9
2 SGTC_1929 genistein trimethyl ether 5.21 50.5 µM 2.10E-9 5 9.46E-8
3 SGTC_3145 9085516 4.13 49.5 µM 1.63E-6 fatty acid desaturase (OLE1) 23 1.83E-5
4 SGTC_445 e6 berbamine 3.78 66.0 µM 1.02E-5 NEO1-PIK1 118 7.89E-5
5 SGTC_2372 9071633 3.64 200.0 µM 1.99E-5 15 1.34E-4
6 SGTC_815 1582-0027 3.51 36.9 µM 3.72E-5 49 2.20E-4
7 SGTC_1257 0669-0121 3.44 16.0 µM 5.28E-5 44 2.91E-4
8 SGTC_823 0417-1665 3.35 178.0 µM 8.07E-5 57 4.08E-4
9 SGTC_2594 a-mangostin 3.17 100.0 µM 1.75E-4 65 7.57E-4
10 SGTC_3197 9113331 3.12 49.5 µM 2.22E-4 81 9.15E-4
11 SGTC_3006 9075424 3.10 71.4 µM 2.37E-4 41 9.64E-4
12 SGTC_3045 9092950 2.95 49.5 µM 4.42E-4 59 0.00158
13 SGTC_1121 fusaric acid 2.94 630.5 nM 4.56E-4 80 0.00162
14 SGTC_450 aminopyrene 2.94 156.0 nM 4.59E-4 89 0.00163
15 SGTC_962 1254-0300 2.94 21.5 µM 4.61E-4 64 0.00164
16 SGTC_2179 6298986 2.93 200.0 µM 4.83E-4 heme requiring 56 0.00170
17 SGTC_2294 7971431 2.88 200.0 µM 5.92E-4 60 0.00200
18 SGTC_950 1165-0508 2.87 94.1 µM 6.05E-4 76 0.00204
19 SGTC_1245 0418-0076 2.87 17.2 µM 6.18E-4 ERG2 81 0.00207
20 SGTC_20 0481-0013 2.86 4.9 µM 6.48E-4 80 0.00215

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 9.26E-20 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.130 3.59E-14 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.110 1.72E-10 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.107 4.82E-10 YML050W AIM32 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.104 1.78E-9 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.101 5.07E-9 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.100 7.38E-9 YAL040C CLN3 hom G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
0.098 1.70E-8 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.095 3.82E-8 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.094 5.24E-8 YNR061C YNR061C hom Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.093 6.00E-8 YER153C PET122 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
0.093 6.47E-8 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.091 1.46E-7 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.090 1.62E-7 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.089 2.21E-7 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1