YEL068C_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL068C / YEL068C

Click on Significant Values for Screen Details ID:SGTC_343|Compound:4130-2827|FD-Score:-3.69|P-value:7.67E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.97|P-value:2.57E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.89|P-value:3.26E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.70|P-value:7.78E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.04|P-value:1.83E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.78|P-value:5.31E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-2.96|P-value:2.67E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.87|P-value:2.56E-6 ID:SGTC_1656|Compound:st012921|FD-Score:2.95|P-value:2.52E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.07|P-value:1.49E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.74|P-value:6.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.93|P-value:1.85E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.70|P-value:7.22E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.81|P-value:5.01E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.80|P-value:4.85E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.17|P-value:4.51E-7 ID:SGTC_2823|Compound:7987624|FD-Score:3.28|P-value:5.54E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-2.77|P-value:5.97E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.51|P-value:1.78E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-2.92|P-value:3.15E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.74|P-value:6.86E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.69|P-value:7.67E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.97|P-value:2.57E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.89|P-value:3.26E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.70|P-value:7.78E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.04|P-value:1.83E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.78|P-value:5.31E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-2.96|P-value:2.67E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.87|P-value:2.56E-6 ID:SGTC_1656|Compound:st012921|FD-Score:2.95|P-value:2.52E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.07|P-value:1.49E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.74|P-value:6.13E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.93|P-value:1.85E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.70|P-value:7.22E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.81|P-value:5.01E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.80|P-value:4.85E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.17|P-value:4.51E-7 ID:SGTC_2823|Compound:7987624|FD-Score:3.28|P-value:5.54E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-2.77|P-value:5.97E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.51|P-value:1.78E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-2.92|P-value:3.15E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.74|P-value:6.86E-4

Top fitness defect scores for YEL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2669 eugenol 4.17 100.0 µM 4.51E-7 9 1.49E-5
2 SGTC_2052 5265182 3.93 7.1 µM 1.85E-6 30 4.20E-5
3 SGTC_1586 deoxycorticosterone acetate 3.87 53.7 µM 2.56E-6 11 5.34E-5
4 SGTC_3003 9075612 3.51 71.4 µM 1.78E-5 30 2.22E-4
5 SGTC_2823 7987624 3.28 58.4 µM 5.54E-5 68 5.13E-4
6 SGTC_1686 st019653 3.07 115.5 µM 1.49E-4 mitochondrial processes 32 0.00106
7 SGTC_1656 st012921 2.95 11.0 µM 2.52E-4 68 0.00157
8 SGTC_437 s-farnesyl-l-cysteine methyl ester 2.89 6.7 µM 3.26E-4 63 0.00190
9 SGTC_2667 digitoxin 2.80 100.0 µM 4.85E-4 30 0.00255
10 SGTC_1000 4048-0884 2.78 8.7 µM 5.31E-4 copper-dependent oxidative stress 91 0.00273
11 SGTC_2050 5263056 2.74 171.0 µM 6.13E-4 fatty acid desaturase (OLE1) 121 0.00303
12 SGTC_2107 5363541 2.70 170.2 µM 7.22E-4 67 0.00342
13 SGTC_359 0081-0058 2.60 15.9 µM 0.00108 60S ribosome export 145 0.00462
14 SGTC_1194 1488-0194 2.60 225.0 µM 0.00109 125 0.00464
15 SGTC_2296 7971656 2.58 126.5 µM 0.00118 127 0.00492
16 SGTC_1642 st009582 2.55 77.7 µM 0.00132 RPP1 & pyrimidine depletion 96 0.00534
17 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 2.54 62.6 µM 0.00140 TSC3-RPN4 86 0.00558
18 SGTC_479 n-linoleoylglycine 2.52 10.0 µM 0.00147 76 0.00581
19 SGTC_24 0417-1663 2.51 219.0 µM 0.00156 89 0.00606
20 SGTC_1635 st007035 2.48 42.4 µM 0.00172 367 0.00652

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.87E-14 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.121 2.32E-12 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.118 6.54E-12 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.111 1.01E-10 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.108 2.97E-10 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.108 3.04E-10 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.105 8.92E-10 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.103 2.13E-9 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.102 3.07E-9 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.099 1.03E-8 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.095 3.30E-8 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.093 6.36E-8 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.092 8.50E-8 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.092 1.04E-7 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.090 1.75E-7 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p