HIPHOP chemogenomics database

YER011W / TIR1

Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking

Zygosity: Homozygous strain

fixedexpanded
Profile for YER011W / TIR1

Click on Significant Values for Screen Details

Top fitness defect scores for YER011W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1717	st033143	7.73	58.0 µM	9.04E-17		6	5.21E-15
2	SGTC_524	r073-0010	5.21	27.8 µM	1.28E-8		23	9.21E-8
3	SGTC_2365	9042475	5.00	200.0 µM	4.56E-8		15	2.85E-7
4	SGTC_3009	9080819	4.44	71.4 µM	1.01E-6		10	4.47E-6
5	SGTC_2290	7904846	4.29	200.0 µM	2.20E-6		14	8.93E-6
6	SGTC_1131	3454-3128	3.65	32.3 µM	4.48E-5		58	1.30E-4
7	SGTC_3135	9127742	3.61	49.5 µM	5.29E-5		32	1.50E-4
8	SGTC_2281	7943571	3.61	200.0 µM	5.34E-5		17	1.51E-4
9	SGTC_646	4092-0839	3.54	27.3 µM	7.16E-5	plasma membrane duress	36	1.97E-4
10	SGTC_1037	k284-1091	3.41	78.7 µM	1.25E-4		23	3.22E-4
11	SGTC_815	1582-0027	3.28	36.9 µM	2.15E-4		65	5.23E-4
12	SGTC_1479	0549-0158	3.24	134.0 µM	2.54E-4		65	6.04E-4
13	SGTC_1409	3909-8004	3.20	61.9 µM	2.88E-4		55	6.76E-4
14	SGTC_2246	7293507	3.11	91.6 µM	4.18E-4		71	9.41E-4
15	SGTC_1568	digitonin	3.09	820.0 nM	4.46E-4	sphingolipid biosynthesis & PDR1	68	9.97E-4
16	SGTC_2254	7938975	3.05	95.2 µM	5.22E-4		93	0.00115
17	SGTC_279	1273-0055	3.03	2.9 µM	5.54E-4	azole & statin	78	0.00121
18	SGTC_67	0335-0847	3.02	266.0 µM	5.73E-4	ubiquinone biosynthesis & proteasome	180	0.00125
19	SGTC_770	0389-1121	3.01	67.2 µM	6.05E-4	RPP1 & pyrimidine depletion	68	0.00131
20	SGTC_2529	gangaleoidin	2.95	93.6 µM	7.63E-4		53	0.00161

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.338	3.48E-90	YLR401C	DUS3	hom	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.186	1.43E-27	YGR185C	TYS1	het	Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.185	2.33E-27	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.180	6.56E-26	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.174	2.89E-24	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.169	7.10E-23	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.167	2.45E-22	YKL022C	CDC16	het	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.166	4.97E-22	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.165	5.86E-22	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.163	2.31E-21	YGR216C	GPI1	het	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.162	4.29E-21	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162	4.70E-21	YKR023W_p	YKR023W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160	1.21E-20	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.159	1.57E-20	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.159	2.12E-20	YJR092W	BUD4	hom	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p