YER011W / TIR1

Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking

Zygosity: Homozygous strain
fixedexpanded
Profile for YER011W / TIR1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.84|P-value:3.11E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.16|P-value:5.06E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:5.54E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.08|P-value:6.68E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.21|P-value:1.28E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-4.32|P-value:3.11E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.47|P-value:1.50E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.88|P-value:2.51E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.54|P-value:7.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:2.93|P-value:8.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.66|P-value:6.80E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.01|P-value:6.05E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.28|P-value:2.15E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.02|P-value:8.37E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.17|P-value:4.83E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.83|P-value:3.62E-13 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.20|P-value:2.88E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.24|P-value:2.54E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.09|P-value:4.46E-4 ID:SGTC_1717|Compound:st033143|FD-Score:7.73|P-value:9.04E-17 ID:SGTC_1818|Compound:st052136|FD-Score:-3.21|P-value:4.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.20|P-value:4.24E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.32|P-value:2.69E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.54|P-value:1.12E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.11|P-value:4.18E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.61|P-value:5.34E-5 ID:SGTC_2282|Compound:7944268|FD-Score:2.94|P-value:7.73E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.29|P-value:2.20E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.15|P-value:5.27E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.00|P-value:4.56E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:2.95|P-value:7.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.41|P-value:1.88E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.10|P-value:6.27E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.44|P-value:1.01E-6 ID:SGTC_3135|Compound:9127742|FD-Score:3.61|P-value:5.29E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.01|P-value:8.72E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.02|P-value:5.73E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.84|P-value:3.11E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.16|P-value:5.06E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:5.54E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.08|P-value:6.68E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.21|P-value:1.28E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-4.32|P-value:3.11E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.47|P-value:1.50E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.88|P-value:2.51E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.54|P-value:7.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:2.93|P-value:8.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.66|P-value:6.80E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.01|P-value:6.05E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.28|P-value:2.15E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.02|P-value:8.37E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.17|P-value:4.83E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.83|P-value:3.62E-13 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.20|P-value:2.88E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.24|P-value:2.54E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.09|P-value:4.46E-4 ID:SGTC_1717|Compound:st033143|FD-Score:7.73|P-value:9.04E-17 ID:SGTC_1818|Compound:st052136|FD-Score:-3.21|P-value:4.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.20|P-value:4.24E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.32|P-value:2.69E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.54|P-value:1.12E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.11|P-value:4.18E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.61|P-value:5.34E-5 ID:SGTC_2282|Compound:7944268|FD-Score:2.94|P-value:7.73E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.29|P-value:2.20E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.15|P-value:5.27E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.00|P-value:4.56E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:2.95|P-value:7.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.41|P-value:1.88E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.10|P-value:6.27E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.44|P-value:1.01E-6 ID:SGTC_3135|Compound:9127742|FD-Score:3.61|P-value:5.29E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.01|P-value:8.72E-4

Top fitness defect scores for YER011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 7.73 58.0 µM 9.04E-17 6 5.21E-15
2 SGTC_524 r073-0010 5.21 27.8 µM 1.28E-8 23 9.21E-8
3 SGTC_2365 9042475 5.00 200.0 µM 4.56E-8 15 2.85E-7
4 SGTC_3009 9080819 4.44 71.4 µM 1.01E-6 10 4.47E-6
5 SGTC_2290 7904846 4.29 200.0 µM 2.20E-6 14 8.93E-6
6 SGTC_1131 3454-3128 3.65 32.3 µM 4.48E-5 58 1.30E-4
7 SGTC_3135 9127742 3.61 49.5 µM 5.29E-5 32 1.50E-4
8 SGTC_2281 7943571 3.61 200.0 µM 5.34E-5 17 1.51E-4
9 SGTC_646 4092-0839 3.54 27.3 µM 7.16E-5 plasma membrane duress 36 1.97E-4
10 SGTC_1037 k284-1091 3.41 78.7 µM 1.25E-4 23 3.22E-4
11 SGTC_815 1582-0027 3.28 36.9 µM 2.15E-4 65 5.23E-4
12 SGTC_1479 0549-0158 3.24 134.0 µM 2.54E-4 65 6.04E-4
13 SGTC_1409 3909-8004 3.20 61.9 µM 2.88E-4 55 6.76E-4
14 SGTC_2246 7293507 3.11 91.6 µM 4.18E-4 71 9.41E-4
15 SGTC_1568 digitonin 3.09 820.0 nM 4.46E-4 sphingolipid biosynthesis & PDR1 68 9.97E-4
16 SGTC_2254 7938975 3.05 95.2 µM 5.22E-4 93 0.00115
17 SGTC_279 1273-0055 3.03 2.9 µM 5.54E-4 azole & statin 78 0.00121
18 SGTC_67 0335-0847 3.02 266.0 µM 5.73E-4 ubiquinone biosynthesis & proteasome 180 0.00125
19 SGTC_770 0389-1121 3.01 67.2 µM 6.05E-4 RPP1 & pyrimidine depletion 68 0.00131
20 SGTC_2529 gangaleoidin 2.95 93.6 µM 7.63E-4 53 0.00161

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.338 3.48E-90 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.186 1.43E-27 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.185 2.33E-27 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.180 6.56E-26 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.174 2.89E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.169 7.10E-23 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.167 2.45E-22 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.166 4.97E-22 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.165 5.86E-22 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.163 2.31E-21 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.162 4.29E-21 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 4.70E-21 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160 1.21E-20 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.159 1.57E-20 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.159 2.12E-20 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p