YER019C-A / SBH2

Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER019C-A / SBH2

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:6.53|P-value:3.51E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:12.20|P-value:2.00E-34 ID:SGTC_67|Compound:0335-0847|FD-Score:5.45|P-value:2.55E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.33|P-value:5.00E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:9.39|P-value:3.80E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:7.97|P-value:9.14E-16 ID:SGTC_142|Compound:0335-0849|FD-Score:8.77|P-value:1.13E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:4.84|P-value:6.62E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:11.80|P-value:2.68E-32 ID:SGTC_163|Compound:1327-0036|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.59|P-value:2.43E-11 ID:SGTC_188|Compound:3229-0966|FD-Score:3.90|P-value:4.89E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.78|P-value:8.89E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:8.53|P-value:8.69E-18 ID:SGTC_373|Compound:0844-0104|FD-Score:7.56|P-value:2.23E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:6.52|P-value:3.77E-11 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.60|P-value:1.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.52|P-value:3.90E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.62|P-value:2.37E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.71|P-value:1.05E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.97|P-value:3.60E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.70|P-value:1.06E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.84|P-value:6.18E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.14|P-value:4.32E-10 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.81|P-value:6.88E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.57|P-value:2.49E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.34|P-value:4.09E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.21|P-value:7.39E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.73|P-value:1.12E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.34|P-value:7.02E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.27|P-value:5.26E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.69|P-value:1.28E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.25|P-value:6.51E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.34|P-value:4.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.31|P-value:4.59E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.68|P-value:1.35E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.07|P-value:2.34E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.86|P-value:5.57E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.92|P-value:5.07E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.51|P-value:2.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:6.13|P-value:4.63E-10 ID:SGTC_16|Compound:erodoxin|FD-Score:4.07|P-value:2.40E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:6.53|P-value:3.51E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:12.20|P-value:2.00E-34 ID:SGTC_67|Compound:0335-0847|FD-Score:5.45|P-value:2.55E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.33|P-value:5.00E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:9.39|P-value:3.80E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:7.97|P-value:9.14E-16 ID:SGTC_142|Compound:0335-0849|FD-Score:8.77|P-value:1.13E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:4.84|P-value:6.62E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:11.80|P-value:2.68E-32 ID:SGTC_163|Compound:1327-0036|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.59|P-value:2.43E-11 ID:SGTC_188|Compound:3229-0966|FD-Score:3.90|P-value:4.89E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.78|P-value:8.89E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:8.53|P-value:8.69E-18 ID:SGTC_373|Compound:0844-0104|FD-Score:7.56|P-value:2.23E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:6.52|P-value:3.77E-11 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.60|P-value:1.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.52|P-value:3.90E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.62|P-value:2.37E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:3.71|P-value:1.05E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.97|P-value:3.60E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.70|P-value:1.06E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.84|P-value:6.18E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.14|P-value:4.32E-10 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.81|P-value:6.88E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.57|P-value:2.49E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.64|P-value:1.56E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.34|P-value:4.09E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.21|P-value:7.39E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.73|P-value:1.12E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.34|P-value:7.02E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.27|P-value:5.26E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.69|P-value:1.28E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.25|P-value:6.51E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.34|P-value:4.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.31|P-value:4.59E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.68|P-value:1.35E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.07|P-value:2.34E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.86|P-value:5.57E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.92|P-value:5.07E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.51|P-value:2.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:6.13|P-value:4.63E-10

Top fitness defect scores for YER019C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 12.20 272.1 µM 2.00E-34 ubiquinone biosynthesis & proteasome 29 1.23E-34
2 SGTC_158 k038-0087 11.80 26.4 µM 2.68E-32 ubiquinone biosynthesis & proteasome 21 1.72E-32
3 SGTC_103 0844-0104 9.39 51.8 µM 3.80E-21 ERAD & cell cycle 34 2.98E-21
4 SGTC_142 0335-0849 8.77 62.7 µM 1.13E-18 ubiquinone biosynthesis & proteasome 40 9.26E-19
5 SGTC_216 k038-0035 8.53 28.4 µM 8.69E-18 ubiquinone biosynthesis & proteasome 10 7.21E-18
6 SGTC_137 0438-0332 7.97 85.4 µM 9.14E-16 ubiquinone biosynthesis & proteasome 37 7.84E-16
7 SGTC_373 0844-0104 7.56 25.9 µM 2.23E-14 ERAD & cell cycle 13 1.96E-14
8 SGTC_165 k038-0023 6.59 64.4 µM 2.43E-11 ubiquinone biosynthesis & proteasome 17 2.23E-11
9 SGTC_36 0335-0881 6.53 14.2 µM 3.51E-11 ubiquinone biosynthesis & proteasome 51 3.24E-11
10 SGTC_384 k007-0144 6.52 5.2 µM 3.77E-11 ERAD & cell cycle 20 3.48E-11
11 SGTC_513 4245-1575 6.52 41.7 µM 3.90E-11 unfolded protein response 40 3.60E-11
12 SGTC_1161 k007-0610 6.14 110.0 µM 4.32E-10 ERAD & cell cycle 58 4.05E-10
13 SGTC_3182 9108849 6.13 49.5 µM 4.63E-10 RPP1 & pyrimidine depletion 1 4.34E-10
14 SGTC_67 0335-0847 5.45 266.0 µM 2.55E-8 ubiquinone biosynthesis & proteasome 75 2.45E-8
15 SGTC_86 0417-1630 5.33 471.9 µM 5.00E-8 ubiquinone biosynthesis & proteasome 103 4.83E-8
16 SGTC_152 4469-0003 4.84 551.2 µM 6.62E-7 11 6.49E-7
17 SGTC_200 k038-0079 4.78 37.5 µM 8.89E-7 ubiquinone biosynthesis & proteasome 42 8.73E-7
18 SGTC_1437 4092-1038 4.73 11.6 µM 1.12E-6 7 1.10E-6
19 SGTC_1239 0337-0584 4.57 35.4 µM 2.49E-6 unfolded protein response 38 2.46E-6
20 SGTC_1717 st033143 4.34 58.0 µM 7.02E-6 28 6.97E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.532 4.83E-244 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.497 7.17E-209 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.485 4.06E-197 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.463 1.13E-177 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.463 1.59E-177 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.459 1.37E-174 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.458 8.57E-174 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.455 5.29E-171 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.454 4.04E-170 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.454 6.02E-170 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.445 1.12E-162 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.445 1.11E-162 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.441 1.04E-159 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.432 2.72E-152 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.423 2.29E-145 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)