YER028C / MIG3

Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER028C / MIG3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.56|P-value:2.02E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.15|P-value:9.37E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:5.59|P-value:7.56E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:1.42E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.45|P-value:1.77E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.19|P-value:6.44E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.18|P-value:1.18E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.00|P-value:4.29E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.57|P-value:9.67E-15 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.10|P-value:8.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:13.50|P-value:6.58E-43 ID:SGTC_394|Compound:menadione|FD-Score:-3.42|P-value:2.78E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.14|P-value:7.50E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.06|P-value:9.88E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.02|P-value:2.32E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.17|P-value:6.70E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.15|P-value:7.10E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.51|P-value:1.94E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.64|P-value:8.96E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.81|P-value:5.82E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.86|P-value:4.77E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.26|P-value:4.84E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.51|P-value:2.22E-11 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.19|P-value:6.27E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.93|P-value:3.51E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.57|P-value:1.87E-6 ID:SGTC_1755|Compound:st041960|FD-Score:3.71|P-value:8.56E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.61|P-value:1.29E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.07|P-value:9.51E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.95|P-value:3.23E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.26|P-value:4.98E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-5.05|P-value:1.66E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.27|P-value:1.14E-10 ID:SGTC_2318|Compound:6029776|FD-Score:3.47|P-value:2.24E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.33|P-value:3.79E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.85|P-value:4.78E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.84|P-value:4.99E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.33|P-value:3.75E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.39|P-value:4.45E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:12.90|P-value:1.78E-39 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.96|P-value:3.14E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.19|P-value:6.33E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.26|P-value:1.19E-10 ID:SGTC_2896|Compound:9052656|FD-Score:-3.73|P-value:8.35E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.83|P-value:5.35E-5 ID:SGTC_3169|Compound:9102970|FD-Score:3.15|P-value:7.21E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.17|P-value:6.75E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.51|P-value:2.48E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.66|P-value:1.10E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.30|P-value:6.83E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.28|P-value:4.44E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.56|P-value:2.02E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.15|P-value:9.37E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:5.59|P-value:7.56E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:5.07|P-value:1.42E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.45|P-value:1.77E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.19|P-value:6.44E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.18|P-value:1.18E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.00|P-value:4.29E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.57|P-value:9.67E-15 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.10|P-value:8.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:13.50|P-value:6.58E-43 ID:SGTC_394|Compound:menadione|FD-Score:-3.42|P-value:2.78E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.10|P-value:8.58E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.14|P-value:7.50E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.06|P-value:9.88E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.02|P-value:2.32E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.17|P-value:6.70E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.61|P-value:1.30E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.15|P-value:7.10E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.51|P-value:1.94E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.64|P-value:8.96E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.67|P-value:1.03E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.81|P-value:5.82E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.86|P-value:4.77E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.26|P-value:4.84E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.51|P-value:2.22E-11 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.19|P-value:6.27E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.93|P-value:3.51E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.57|P-value:1.87E-6 ID:SGTC_1755|Compound:st041960|FD-Score:3.71|P-value:8.56E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.61|P-value:1.29E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.07|P-value:9.51E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.95|P-value:3.23E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.26|P-value:4.98E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-5.05|P-value:1.66E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.27|P-value:1.14E-10 ID:SGTC_2318|Compound:6029776|FD-Score:3.47|P-value:2.24E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.33|P-value:3.79E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.85|P-value:4.78E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.84|P-value:4.99E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.33|P-value:3.75E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.39|P-value:4.45E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:12.90|P-value:1.78E-39 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.96|P-value:3.14E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.19|P-value:6.33E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.26|P-value:1.19E-10 ID:SGTC_2896|Compound:9052656|FD-Score:-3.73|P-value:8.35E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.83|P-value:5.35E-5 ID:SGTC_3169|Compound:9102970|FD-Score:3.15|P-value:7.21E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.17|P-value:6.75E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.51|P-value:2.48E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.66|P-value:1.10E-4 ID:SGTC_3314|Compound:9135860|FD-Score:4.30|P-value:6.83E-6 ID:SGTC_3322|Compound:9139058|FD-Score:3.28|P-value:4.44E-4

Top fitness defect scores for YER028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 13.50 1.1 µM 6.58E-43 mitochondrial stress 14 5.48E-42
2 SGTC_2533 agelasine 12.90 13.7 µM 1.78E-39 ERG2 2 1.25E-38
3 SGTC_236 1509-0011 9.00 5.3 µM 4.29E-20 221 1.11E-19
4 SGTC_275 trichlorophene 7.57 5.7 µM 9.67E-15 mitochondrial stress 83 1.91E-14
5 SGTC_1144 3486-0183 6.64 12.5 µM 8.96E-12 2 1.52E-11
6 SGTC_1371 2421-0008 6.51 32.7 µM 2.22E-11 mitochondrial processes 5 3.71E-11
7 SGTC_2232 chlorophetanol 6.27 41.5 µM 1.14E-10 TRP & mitochondrial translation 38 1.83E-10
8 SGTC_2688 kanamycin b 6.26 96.7 µM 1.19E-10 calcium & mitochondrial duress 139 1.92E-10
9 SGTC_63 0099-0242 5.59 26.7 µM 7.56E-9 mitochondrial stress 34 1.11E-8
10 SGTC_70 0141-0289 5.45 43.3 µM 1.77E-8 mitochondrial stress 100 2.54E-8
11 SGTC_58 0957-0393 5.15 9.0 µM 9.37E-8 cell wall 268 1.30E-7
12 SGTC_68 0986-0284 5.07 82.8 µM 1.42E-7 27 1.96E-7
13 SGTC_1742 st038235 4.57 28.9 µM 1.87E-6 mitochondrial stress 94 2.42E-6
14 SGTC_10 0279-0212 4.56 42.6 µM 2.02E-6 TRP & mitochondrial translation 89 2.61E-6
15 SGTC_3210 9128157 4.51 49.5 µM 2.48E-6 34 3.20E-6
16 SGTC_2526 patulin 4.39 37.6 µM 4.45E-6 68 5.67E-6
17 SGTC_3314 9135860 4.30 59.4 µM 6.83E-6 9 8.63E-6
18 SGTC_173 1273-0061 4.18 2.7 µM 1.18E-5 mitochondrial stress 179 1.48E-5
19 SGTC_679 0422-0091 4.17 41.4 µM 1.20E-5 Golgi 26 1.50E-5
20 SGTC_832 4083-0019 4.02 164.0 µM 2.32E-5 translation 91 2.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.433 8.35E-153 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.423 4.59E-145 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.422 2.38E-145 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.412 1.26E-137 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.404 6.77E-132 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.403 3.29E-131 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.402 3.42E-130 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.398 7.79E-128 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.390 3.10E-122 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.389 1.39E-121 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.389 2.04E-121 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.388 5.24E-121 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.385 2.85E-119 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.382 3.31E-117 YFR019W FAB1 hom 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
0.382 9.83E-117 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets