YER030W / CHZ1

Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER030W / CHZ1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.03|P-value:1.89E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.74|P-value:6.70E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.30|P-value:5.59E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.63|P-value:2.99E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.48|P-value:2.35E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.44|P-value:2.74E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:2.88|P-value:3.70E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.57|P-value:4.28E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.17|P-value:9.96E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.24|P-value:7.49E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.48|P-value:7.40E-8 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.27|P-value:6.44E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:2.89|P-value:3.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.19|P-value:2.20E-13 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.86|P-value:3.06E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-2.99|P-value:2.29E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.72|P-value:7.19E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.25|P-value:7.00E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.10|P-value:1.39E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.41|P-value:3.15E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.79|P-value:5.45E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.86|P-value:3.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.12|P-value:1.33E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.96|P-value:1.80E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.68|P-value:2.21E-8 ID:SGTC_2016|Compound:5121758|FD-Score:-3.07|P-value:1.65E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.16|P-value:1.08E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.17|P-value:5.30E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.39|P-value:3.57E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.25|P-value:6.91E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.26|P-value:6.65E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.96|P-value:3.28E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.68|P-value:8.63E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.67|P-value:9.02E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.99|P-value:2.31E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.22|P-value:3.75E-7 ID:SGTC_2846|Compound:9008642|FD-Score:2.72|P-value:7.18E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.13|P-value:1.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.31|P-value:5.30E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.08|P-value:1.56E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.14|P-value:1.17E-4 ID:SGTC_3196|Compound:9111891|FD-Score:2.85|P-value:4.22E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.44|P-value:2.76E-5 ID:SGTC_3336|Compound:9143619|FD-Score:2.73|P-value:6.89E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.03|P-value:1.89E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.74|P-value:6.70E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.30|P-value:5.59E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.63|P-value:2.99E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.48|P-value:2.35E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.44|P-value:2.74E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:2.88|P-value:3.70E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.57|P-value:4.28E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.17|P-value:9.96E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.24|P-value:7.49E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.48|P-value:7.40E-8 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.27|P-value:6.44E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:2.89|P-value:3.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.19|P-value:2.20E-13 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.86|P-value:3.06E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-2.99|P-value:2.29E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.72|P-value:7.19E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.25|P-value:7.00E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.10|P-value:1.39E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.41|P-value:3.15E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.79|P-value:5.45E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.86|P-value:3.94E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.12|P-value:1.33E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.96|P-value:1.80E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.68|P-value:2.21E-8 ID:SGTC_2016|Compound:5121758|FD-Score:-3.07|P-value:1.65E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.16|P-value:1.08E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.17|P-value:5.30E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.39|P-value:3.57E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.25|P-value:6.91E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.26|P-value:6.65E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.96|P-value:3.28E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.68|P-value:8.63E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.67|P-value:9.02E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.99|P-value:2.31E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.22|P-value:3.75E-7 ID:SGTC_2846|Compound:9008642|FD-Score:2.72|P-value:7.18E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.13|P-value:1.21E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.31|P-value:5.30E-5 ID:SGTC_2986|Compound:9022445|FD-Score:3.08|P-value:1.56E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.14|P-value:1.17E-4 ID:SGTC_3196|Compound:9111891|FD-Score:2.85|P-value:4.22E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.44|P-value:2.76E-5 ID:SGTC_3336|Compound:9143619|FD-Score:2.73|P-value:6.89E-4

Top fitness defect scores for YER030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_806 3966-4455 4.57 5.9 µM 4.28E-8 10 2.44E-6
2 SGTC_916 4466-0038 4.48 42.0 nM 7.40E-8 cell wall 52 3.66E-6
3 SGTC_2693 st077581 4.22 40.7 µM 3.75E-7 26 1.21E-5
4 SGTC_354 2783-3500 3.44 4.9 µM 2.74E-5 cell wall 67 2.89E-4
5 SGTC_3198 9112019 3.44 49.5 µM 2.76E-5 mitochondrial processes 30 2.91E-4
6 SGTC_1395 3486-0190 3.41 4.3 µM 3.15E-5 30 3.20E-4
7 SGTC_2415 st077333 3.39 57.7 µM 3.57E-5 79 3.52E-4
8 SGTC_180 1486-1293 3.30 102.8 µM 5.59E-5 59 4.91E-4
9 SGTC_2491 paeonol 3.25 100.0 µM 6.91E-5 18 5.74E-4
10 SGTC_1301 naphtanilide LB 3.25 4.8 µM 7.00E-5 heme requiring 27 5.80E-4
11 SGTC_811 0416-0114 3.17 265.0 µM 9.96E-5 58 7.53E-4
12 SGTC_2103 5378138 3.16 10.0 µM 1.08E-4 51 8.01E-4
13 SGTC_3045 9092950 3.14 49.5 µM 1.17E-4 46 8.48E-4
14 SGTC_2871 9038510 3.13 13.0 µM 1.21E-4 48 8.72E-4
15 SGTC_1332 1480-0653 3.10 17.5 µM 1.39E-4 TSC3-RPN4 42 9.62E-4
16 SGTC_2986 9022445 3.08 71.4 µM 1.56E-4 46 0.00105
17 SGTC_41 0478-0632 3.03 82.6 µM 1.89E-4 73 0.00121
18 SGTC_2692 st077426 2.99 47.7 µM 2.31E-4 69 0.00141
19 SGTC_1083 didemethylchlorpromazine sulfoxide 2.95 707.4 nM 2.72E-4 redox potentiating 153 0.00159
20 SGTC_1104 tacrolimus 2.89 29.8 µM 3.51E-4 81 0.00192

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 4.05E-79 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.265 3.52E-55 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.237 5.98E-44 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.217 4.23E-37 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.212 2.15E-35 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.207 1.00E-33 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.205 3.32E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.204 9.42E-33 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.201 9.16E-32 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.194 8.57E-30 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.187 9.28E-28 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.185 3.59E-27 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.183 9.02E-27 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.181 3.95E-26 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.175 1.64E-24 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication