YER042W / MXR1

Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan

Zygosity: Homozygous strain
fixedexpanded
Profile for YER042W / MXR1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.29|P-value:3.22E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:3.95|P-value:1.16E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.59|P-value:4.06E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.43|P-value:6.90E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.87|P-value:1.43E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.50|P-value:5.51E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.25|P-value:4.74E-7 ID:SGTC_696|Compound:1560-0013|FD-Score:3.87|P-value:1.52E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.42|P-value:7.22E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.14|P-value:5.22E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.78|P-value:2.02E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.57|P-value:4.43E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.35|P-value:8.93E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.53|P-value:4.65E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.64|P-value:3.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.86|P-value:1.49E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.59|P-value:4.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.33|P-value:9.18E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.78|P-value:1.86E-13 ID:SGTC_1744|Compound:st037937|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.78|P-value:4.10E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.10|P-value:6.59E-5 ID:SGTC_1976|Compound:st070609|FD-Score:-3.95|P-value:1.08E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:9.26E-4 ID:SGTC_2058|Compound:5236698|FD-Score:6.23|P-value:2.98E-9 ID:SGTC_2061|Compound:5245884|FD-Score:4.10|P-value:6.47E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.92|P-value:1.22E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.82|P-value:1.72E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.28|P-value:4.23E-7 ID:SGTC_2380|Compound:9035439|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.02|P-value:8.91E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.99|P-value:1.59E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.48|P-value:5.93E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.61|P-value:3.84E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.57|P-value:4.40E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.72|P-value:2.45E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.07|P-value:7.44E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.38|P-value:8.05E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.53|P-value:4.92E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.29|P-value:3.22E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:3.95|P-value:1.16E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.59|P-value:4.06E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.43|P-value:6.90E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.87|P-value:1.43E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.50|P-value:5.51E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.25|P-value:4.74E-7 ID:SGTC_696|Compound:1560-0013|FD-Score:3.87|P-value:1.52E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.42|P-value:7.22E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.14|P-value:5.22E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.78|P-value:2.02E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.57|P-value:4.43E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.35|P-value:8.93E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.53|P-value:4.65E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.64|P-value:3.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.86|P-value:1.49E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.59|P-value:4.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.33|P-value:9.18E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.78|P-value:1.86E-13 ID:SGTC_1744|Compound:st037937|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.78|P-value:4.10E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.10|P-value:6.59E-5 ID:SGTC_1976|Compound:st070609|FD-Score:-3.95|P-value:1.08E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:9.26E-4 ID:SGTC_2058|Compound:5236698|FD-Score:6.23|P-value:2.98E-9 ID:SGTC_2061|Compound:5245884|FD-Score:4.10|P-value:6.47E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.92|P-value:1.22E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.82|P-value:1.72E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.28|P-value:4.23E-7 ID:SGTC_2380|Compound:9035439|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.02|P-value:8.91E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.99|P-value:1.59E-6 ID:SGTC_2704|Compound:st078022|FD-Score:3.48|P-value:5.93E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.61|P-value:3.84E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.57|P-value:4.40E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.72|P-value:2.45E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.07|P-value:7.44E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.38|P-value:8.05E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.53|P-value:4.92E-4

Top fitness defect scores for YER042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1534 6-azauridine 7.78 81.6 µM 1.86E-13 RNA pol III & RNase P/MRP 1 3.52E-15
2 SGTC_2058 5236698 6.23 133.0 µM 2.98E-9 7 2.26E-10
3 SGTC_2377 9073351 5.28 62.6 µM 4.23E-7 ergosterol biosynthesis 7 6.51E-8
4 SGTC_541 4513-1321 5.25 94.0 µM 4.74E-7 7 7.41E-8
5 SGTC_2613 3',4'-dimethoxydalbergione 4.99 24.6 µM 1.59E-6 7 2.95E-7
6 SGTC_1900 st060200 4.78 72.8 µM 4.10E-6 11 8.71E-7
7 SGTC_18 0111-0177 4.29 500.0 nM 3.22E-5 52 9.11E-6
8 SGTC_2061 5245884 4.10 81.0 µM 6.47E-5 tubulin folding & SWR complex 19 2.02E-5
9 SGTC_1954 st077032 4.10 68.9 µM 6.59E-5 18 2.07E-5
10 SGTC_2936 9038235 4.07 15.6 µM 7.44E-5 17 2.37E-5
11 SGTC_2380 9035439 4.05 200.0 µM 8.01E-5 endomembrane recycling 18 2.58E-5
12 SGTC_2507 purpurin 4.02 79.7 µM 8.91E-5 copper-dependent oxidative stress 34 2.91E-5
13 SGTC_36 0335-0881 3.95 14.2 µM 1.16E-4 ubiquinone biosynthesis & proteasome 121 3.94E-5
14 SGTC_2149 5554786 3.90 194.8 µM 1.36E-4 cell wall signaling 41 4.71E-5
15 SGTC_696 1560-0013 3.87 611.0 µM 1.52E-4 25 5.34E-5
16 SGTC_1292 0kpi-0043 3.64 232.0 µM 3.48E-4 22 1.37E-4
17 SGTC_2712 st079126 3.61 47.7 µM 3.84E-4 23 1.54E-4
18 SGTC_1744 st037937 3.60 38.9 µM 3.97E-4 41 1.59E-4
19 SGTC_45 0kpi-0036 3.59 14.9 µM 4.06E-4 excess fatty acid 39 1.64E-4
20 SGTC_1377 2944-0135 3.59 198.0 µM 4.13E-4 calcium & mitochondrial duress 48 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.24E-8 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.091 1.27E-7 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.087 5.01E-7 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.082 1.78E-6 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.081 2.82E-6 YCR022C_d YCR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
0.079 4.36E-6 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.077 7.87E-6 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.077 8.12E-6 YOR327C SNC2 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication
0.075 1.43E-5 YLR239C LIP2 hom Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
0.074 1.76E-5 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.074 1.95E-5 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.073 2.41E-5 YCL042W_p YCL042W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.073 2.56E-5 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.072 2.84E-5 YDL040C NAT1 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.072 2.95E-5 YMR180C CTL1 hom RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm