HIPHOP chemogenomics database

YER043C / SAH1

S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor

Zygosity: Heterozygous strain

fixedexpanded
Profile for YER043C / SAH1

Click on Significant Values for Screen Details

Top fitness defect scores for YER043C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1568	digitonin	4.80	820.0 nM	3.24E-8	sphingolipid biosynthesis & PDR1	9	7.97E-7	0.27
2	SGTC_175	3793-3120	4.05	23.7 µM	2.45E-6		3	2.55E-5	0.07
3	SGTC_1944	st076371	3.90	56.9 µM	5.41E-6		3	4.80E-5	0.02
4	SGTC_453	enantio-paf c16	3.63	10.0 µM	2.12E-5		24	1.43E-4	0.04
5	SGTC_822	1487-0950	3.34	154.0 µM	7.90E-5		6	4.12E-4	0.06
6	SGTC_2563	tomatine	3.23	8.5 µM	1.33E-4		21	6.28E-4	0.12
7	SGTC_2837	9008476	3.19	45.5 µM	1.58E-4		12	7.20E-4	0.01
8	SGTC_1634	st006576	3.18	41.0 µM	1.60E-4	TSC3-RPN4	14	7.25E-4	0.17
9	SGTC_2811	7967822	3.15	32.5 µM	1.84E-4		13	8.13E-4	0.04
10	SGTC_907	3448-6986	3.13	75.5 µM	2.06E-4		14	8.89E-4	0.07
11	SGTC_1695	st026914	3.12	34.5 µM	2.12E-4		8	9.12E-4	0.01
12	SGTC_1918	oxolan-2-ylmethyl 3-bromobenzoate	3.11	70.1 µM	2.23E-4		11	9.49E-4	0.05
13	SGTC_886	0866-0150	3.10	153.0 µM	2.32E-4		10	9.79E-4	0.01
14	SGTC_621	3584-0052	3.01	32.1 µM	3.26E-4		14	0.00129	0.03
15	SGTC_1739	st037196	2.98	92.5 µM	3.82E-4		13	0.00146	0.01
16	SGTC_286	k060-0067	2.88	22.9 µM	5.50E-4	tubulin folding & SWR complex	19	0.00196	0.01
17	SGTC_893	0958-0369	2.87	48.9 µM	5.92E-4		15	0.00208	0.05
18	SGTC_839	0122-0028	2.84	230.0 µM	6.45E-4	RSC complex & mRNA processing	61	0.00223	0.01
19	SGTC_1810	st050138	2.84	53.0 µM	6.66E-4	PDR1	13	0.00229	0.03
20	SGTC_354	2783-3500	2.82	4.9 µM	6.96E-4	cell wall	50	0.00237	0.00

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.195	5.90E-30	YMR102C_p	YMR102C_p	hom	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.181	5.52E-26	YHR073W	OSH3	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.171	1.92E-23	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.166	4.30E-22	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.163	2.78E-21	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.161	7.74E-21	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.160	8.92E-21	YFR027W	ECO1	het	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.157	4.99E-20	YKL152C	GPM1	het	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.151	1.20E-18	YGR209C	TRX2	hom	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.141	1.83E-16	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135	4.86E-15	YNL163C	RIA1	het	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.135	4.86E-15	YMR049C	ERB1	het	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.131	3.20E-14	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.123	8.65E-13	YGL111W	NSA1	het	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.123	8.68E-13	YKL124W	SSH4	hom	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases