YER045C / ACA1

ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER045C / ACA1

Click on Significant Values for Screen Details ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:1.89E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.02|P-value:7.35E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.18|P-value:4.16E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.22|P-value:3.53E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.57|P-value:8.50E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.97|P-value:1.48E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.13|P-value:4.82E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.95|P-value:9.48E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.68|P-value:5.44E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.20|P-value:3.84E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.81|P-value:3.00E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:5.79|P-value:5.41E-10 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.35|P-value:2.05E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.97|P-value:8.65E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.30|P-value:2.56E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.40|P-value:1.75E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.04|P-value:6.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.60|P-value:7.63E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.57|P-value:8.46E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.62|P-value:6.83E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.14|P-value:4.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.90|P-value:2.03E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.05|P-value:6.64E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.20|P-value:3.86E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.47|P-value:1.31E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.14|P-value:4.85E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.19|P-value:3.84E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-2.97|P-value:8.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:6.41E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.61|P-value:7.23E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.79|P-value:3.21E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.49|P-value:1.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-7.59|P-value:6.47E-16 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:7.56|P-value:8.42E-16 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-6.63|P-value:1.41E-12 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.40|P-value:1.69E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.07|P-value:6.15E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.37|P-value:1.95E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.35|P-value:2.15E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.10|P-value:5.59E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.23|P-value:3.34E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:1.89E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.02|P-value:7.35E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.18|P-value:4.16E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.22|P-value:3.53E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.57|P-value:8.50E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.97|P-value:1.48E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.13|P-value:4.82E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.95|P-value:9.48E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.68|P-value:5.44E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.20|P-value:3.84E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.81|P-value:3.00E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:5.79|P-value:5.41E-10 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.35|P-value:2.05E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.32|P-value:2.43E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.97|P-value:8.65E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.30|P-value:2.56E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.40|P-value:1.75E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.04|P-value:6.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.60|P-value:7.63E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.57|P-value:8.46E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.62|P-value:6.83E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.36|P-value:2.05E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.14|P-value:4.79E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.90|P-value:2.03E-5 ID:SGTC_2145|Compound:5634607|FD-Score:-3.43|P-value:1.48E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.05|P-value:6.64E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.20|P-value:3.86E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.47|P-value:1.31E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.14|P-value:4.85E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.19|P-value:3.84E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-2.97|P-value:8.79E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.06|P-value:6.41E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.61|P-value:7.23E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.79|P-value:3.21E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.49|P-value:1.20E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-7.59|P-value:6.47E-16 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:7.56|P-value:8.42E-16 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-6.63|P-value:1.41E-12 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.40|P-value:1.69E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.07|P-value:6.15E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.37|P-value:1.95E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.35|P-value:2.15E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.10|P-value:5.59E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.23|P-value:3.34E-4

Top fitness defect scores for YER045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2634 4'-methoxyflavone 7.56 100.0 µM 8.42E-16 2 1.95E-14
2 SGTC_798 1287-0182 5.79 476.0 µM 5.41E-10 7 3.47E-9
3 SGTC_421 streptovitacin 3.97 30.0 mM 1.48E-5 21 3.60E-5
4 SGTC_1984 st072354 3.90 53.1 µM 2.03E-5 16 4.81E-5
5 SGTC_785 1270-0111 3.81 65.3 µM 3.00E-5 28 6.85E-5
6 SGTC_552 k242-0005 3.68 476.0 µM 5.44E-5 24 1.18E-4
7 SGTC_1698 5-fluorocytosine 3.62 1.1 µM 6.83E-5 exosome 12 1.45E-4
8 SGTC_1569 carminic acid 3.60 40.6 µM 7.63E-5 26 1.60E-4
9 SGTC_369 0957-0393 3.57 4.5 µM 8.50E-5 cell wall signaling 36 1.77E-4
10 SGTC_2415 st077333 3.47 57.7 µM 1.31E-4 73 2.61E-4
11 SGTC_2230 bromochlorosalicylanilide 3.46 954.5 nM 1.33E-4 10 2.66E-4
12 SGTC_1976 st070609 3.45 63.5 µM 1.42E-4 24 2.82E-4
13 SGTC_1098 clofazimine 3.40 15.1 µM 1.75E-4 heme biosynthesis & mitochondrial translocase 49 3.40E-4
14 SGTC_155 k072-0202 3.38 43.6 µM 1.89E-4 33 3.65E-4
15 SGTC_2823 7987624 3.37 58.4 µM 1.95E-4 60 3.75E-4
16 SGTC_1874 staurosporine 3.36 7.6 µM 2.05E-4 cell wall signaling 49 3.92E-4
17 SGTC_3157 9099274 3.35 49.5 µM 2.09E-4 34 3.99E-4
18 SGTC_2998 9066762 3.35 71.4 µM 2.15E-4 RPP1 & pyrimidine depletion 47 4.10E-4
19 SGTC_811 0416-0114 3.32 265.0 µM 2.43E-4 50 4.57E-4
20 SGTC_366 0181-0206 3.22 4.3 µM 3.53E-4 Golgi 76 6.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.38E-14 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.125 3.75E-13 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.107 5.42E-10 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.099 1.01E-8 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.097 2.12E-8 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.095 3.61E-8 YML030W RCF1 hom Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
0.095 3.90E-8 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.092 1.04E-7 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.081 2.44E-6 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.081 2.59E-6 YDR305C HNT2 hom Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
0.081 2.94E-6 YLL060C GTT2 hom Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
0.079 5.08E-6 YIL074C SER33 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication
0.078 6.67E-6 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.56E-6 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.077 9.00E-6 YJL098W SAP185 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication