YER050C / RSM18

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YER050C / RSM18

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.50|P-value:8.87E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.24|P-value:2.10E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.39|P-value:3.75E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.98|P-value:1.70E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.82|P-value:9.39E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.24|P-value:2.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.89|P-value:9.01E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:4.71E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.32|P-value:2.75E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:15.60|P-value:1.87E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:5.76|P-value:8.56E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.84|P-value:6.79E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.15|P-value:2.72E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.77|P-value:3.57E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.89|P-value:5.85E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.95|P-value:4.95E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.56|P-value:9.93E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.97|P-value:4.63E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.63|P-value:5.79E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.09|P-value:4.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.95|P-value:5.01E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.71|P-value:9.81E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.64|P-value:1.37E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.41|P-value:1.22E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.52|P-value:1.13E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.91|P-value:4.51E-11 ID:SGTC_1722|Compound:st034304|FD-Score:4.08|P-value:3.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.31|P-value:6.82E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.51|P-value:3.83E-10 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-5.05|P-value:1.88E-5 ID:SGTC_1900|Compound:st060200|FD-Score:4.23|P-value:2.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-7.92|P-value:4.17E-11 ID:SGTC_2046|Compound:4110841|FD-Score:-4.18|P-value:3.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.42|P-value:5.00E-8 ID:SGTC_2283|Compound:7944793|FD-Score:5.45|P-value:2.98E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.82|P-value:7.30E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.93|P-value:5.32E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.00|P-value:4.26E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.83|P-value:8.97E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.27|P-value:2.45E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.08|P-value:3.34E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.88|P-value:3.37E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.84|P-value:8.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.02|P-value:5.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:4.61E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.67|P-value:7.00E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.87|P-value:9.30E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.91|P-value:6.74E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.34|P-value:2.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:3.48E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.86|P-value:8.40E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.70|P-value:6.30E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-7.87|P-value:5.67E-11 ID:SGTC_10|Compound:0279-0212|FD-Score:4.50|P-value:8.87E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.24|P-value:2.10E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.39|P-value:3.75E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.98|P-value:1.70E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.82|P-value:9.39E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.24|P-value:2.75E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.89|P-value:9.01E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:4.71E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.32|P-value:2.75E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:15.60|P-value:1.87E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:5.76|P-value:8.56E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.84|P-value:6.79E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.15|P-value:2.72E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.77|P-value:3.57E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.89|P-value:5.85E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.95|P-value:4.95E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.56|P-value:9.93E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.97|P-value:4.63E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.63|P-value:5.79E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:-4.09|P-value:4.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.95|P-value:5.01E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.71|P-value:9.81E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.64|P-value:1.37E-6 ID:SGTC_1624|Compound:st003710|FD-Score:4.41|P-value:1.22E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.52|P-value:1.13E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.91|P-value:4.51E-11 ID:SGTC_1722|Compound:st034304|FD-Score:4.08|P-value:3.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.31|P-value:6.82E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.51|P-value:3.83E-10 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-5.05|P-value:1.88E-5 ID:SGTC_1900|Compound:st060200|FD-Score:4.23|P-value:2.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-7.92|P-value:4.17E-11 ID:SGTC_2046|Compound:4110841|FD-Score:-4.18|P-value:3.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.42|P-value:5.00E-8 ID:SGTC_2283|Compound:7944793|FD-Score:5.45|P-value:2.98E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.82|P-value:7.30E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.93|P-value:5.32E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.00|P-value:4.26E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.83|P-value:8.97E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-4.27|P-value:2.45E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.08|P-value:3.34E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.88|P-value:3.37E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.84|P-value:8.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.02|P-value:5.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.98|P-value:4.61E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.67|P-value:7.00E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.87|P-value:9.30E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.91|P-value:6.74E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.34|P-value:2.00E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.16|P-value:3.48E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.86|P-value:8.40E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.70|P-value:6.30E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-7.87|P-value:5.67E-11

Top fitness defect scores for YER050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 15.60 1.1 µM 1.87E-38 mitochondrial stress 6 2.50E-55
2 SGTC_236 1509-0011 10.00 5.3 µM 4.71E-17 193 5.08E-24
3 SGTC_173 1273-0061 8.89 2.7 µM 9.01E-14 mitochondrial stress 51 3.10E-19
4 SGTC_275 trichlorophene 8.32 5.7 µM 2.75E-12 mitochondrial stress 69 4.50E-17
5 SGTC_1742 st038235 7.31 28.9 µM 6.82E-10 mitochondrial stress 24 1.36E-13
6 SGTC_2250 alverine citrate 6.42 130.0 µM 5.00E-8 43 6.90E-11
7 SGTC_314 1671-0008 5.76 2.7 µM 8.56E-7 6 4.19E-9
8 SGTC_1623 st003709 5.64 20.3 µM 1.37E-6 calcium & mitochondrial duress 14 8.26E-9
9 SGTC_2283 7944793 5.45 200.0 µM 2.98E-6 12 2.53E-8
10 SGTC_118 0083-0097 5.39 135.3 µM 3.75E-6 translation 42 3.53E-8
11 SGTC_119 0121-0043 4.98 24.8 µM 1.70E-5 mitochondrial stress 55 3.10E-7
12 SGTC_704 1310-0270 4.77 142.0 µM 3.57E-5 19 9.04E-7
13 SGTC_1319 1306-0155 4.63 43.7 µM 5.79E-5 10 1.81E-6
14 SGTC_10 0279-0212 4.50 42.6 µM 8.87E-5 TRP & mitochondrial translation 95 3.33E-6
15 SGTC_1624 st003710 4.41 6.2 µM 1.22E-4 calcium & mitochondrial duress 30 5.26E-6
16 SGTC_63 0099-0242 4.24 26.7 µM 2.10E-4 mitochondrial stress 78 1.14E-5
17 SGTC_1900 st060200 4.23 72.8 µM 2.15E-4 17 1.18E-5
18 SGTC_421 streptovitacin 4.15 30.0 mM 2.72E-4 19 1.66E-5
19 SGTC_2540 epiandrosterone 4.08 100.0 µM 3.34E-4 54 2.22E-5
20 SGTC_1722 st034304 4.08 3.6 µM 3.40E-4 mitochondrial processes 21 2.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.520 4.82E-232 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.518 2.19E-229 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.514 8.89E-226 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.512 8.01E-224 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.499 7.68E-211 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.495 8.92E-207 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.495 1.17E-205 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.494 2.13E-206 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.491 7.01E-203 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.490 2.16E-202 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.489 2.60E-201 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.487 1.96E-199 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.481 1.09E-193 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.475 9.29E-189 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.475 4.80E-187 YDR322W MRPL35 hom Mitochondrial ribosomal protein of the large subunit