HIPHOP chemogenomics database
YER057C / HMF1 
Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER057C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.167 | 2.32E-22 | YOL019W-A_p | YOL019W-A_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.147 | 1.01E-17 | YAL028W | FRT2 | hom | Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication |
| 0.129 | 5.66E-14 | YMR006C | PLB2 | hom | Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine |
| 0.114 | 3.76E-11 | YGR072W | UPF3 | hom | Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance |
| 0.109 | 2.77E-10 | YBL055C | YBL055C | hom | 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases |
| 0.105 | 9.10E-10 | YNL120C_d | YNL120C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene |
| 0.100 | 5.62E-9 | YDR169C-A_p | YDR169C-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.095 | 3.31E-8 | YBR271W | EFM2 | hom | S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis |
| 0.094 | 4.24E-8 | YNL066W | SUN4 | hom | Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family |
| 0.094 | 4.45E-8 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |
| 0.090 | 1.81E-7 | YBR287W_p | YBR287W_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene |
| 0.089 | 2.84E-7 | YOR079C | ATX2 | hom | Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation |
| 0.086 | 5.72E-7 | YJR052W | RAD7 | hom | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex |
| 0.086 | 6.22E-7 | YFR032C-B_p | YFR032C-B_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.086 | 6.58E-7 | YOR238W_p | YOR238W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |