YER057C / HMF1

Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro

Zygosity: Homozygous strain
fixedexpanded
Profile for YER057C / HMF1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.06|P-value:2.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.06|P-value:3.92E-9 ID:SGTC_373|Compound:0844-0104|FD-Score:3.08|P-value:2.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.00|P-value:3.08E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.13|P-value:1.21E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.87|P-value:5.06E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:8.58|P-value:5.85E-23 ID:SGTC_427|Compound:1354-0053|FD-Score:2.76|P-value:8.00E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.38|P-value:2.89E-7 ID:SGTC_705|Compound:1124-0212|FD-Score:3.62|P-value:1.76E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.72|P-value:9.67E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.57|P-value:2.29E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.48|P-value:1.53E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.80|P-value:6.77E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.02|P-value:2.75E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-4.72|P-value:3.78E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:1.78E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.77|P-value:7.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.87|P-value:4.85E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.05|P-value:2.50E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.77|P-value:7.87E-4 ID:SGTC_1634|Compound:st006576|FD-Score:5.63|P-value:6.68E-11 ID:SGTC_1664|Compound:st014217|FD-Score:-2.91|P-value:4.48E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.74|P-value:8.59E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.79|P-value:7.54E-6 ID:SGTC_2160|Compound:5660466|FD-Score:5.41|P-value:3.23E-10 ID:SGTC_2170|Compound:morpholine|FD-Score:3.65|P-value:1.50E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.24|P-value:1.07E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.57|P-value:2.26E-5 ID:SGTC_2470|Compound:5664817|FD-Score:2.97|P-value:3.52E-4 ID:SGTC_2479|Compound:5617353|FD-Score:2.78|P-value:7.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.10|P-value:2.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.15|P-value:1.68E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.02|P-value:2.78E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-2.93|P-value:4.16E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.06|P-value:2.45E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.96|P-value:3.79E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-2.74|P-value:9.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:2.94|P-value:3.98E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.72|P-value:9.48E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.80|P-value:7.12E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.07|P-value:2.25E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.82|P-value:1.91E-8 ID:SGTC_2940|Compound:9060638|FD-Score:4.12|P-value:1.30E-6 ID:SGTC_2955|Compound:9076254|FD-Score:2.97|P-value:3.43E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-8.09|P-value:1.32E-20 ID:SGTC_2965|Compound:9082772|FD-Score:5.05|P-value:3.97E-9 ID:SGTC_3108|Compound:9121785|FD-Score:3.01|P-value:2.91E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.76|P-value:8.62E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.06|P-value:2.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.06|P-value:3.92E-9 ID:SGTC_373|Compound:0844-0104|FD-Score:3.08|P-value:2.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.00|P-value:3.08E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.13|P-value:1.21E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.87|P-value:5.06E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:8.58|P-value:5.85E-23 ID:SGTC_427|Compound:1354-0053|FD-Score:2.76|P-value:8.00E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.38|P-value:2.89E-7 ID:SGTC_705|Compound:1124-0212|FD-Score:3.62|P-value:1.76E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.72|P-value:9.67E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.57|P-value:2.29E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.48|P-value:1.53E-7 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.80|P-value:6.77E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.02|P-value:2.75E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:-4.72|P-value:3.78E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:1.78E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.77|P-value:7.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.87|P-value:4.85E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.05|P-value:2.50E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.77|P-value:7.87E-4 ID:SGTC_1634|Compound:st006576|FD-Score:5.63|P-value:6.68E-11 ID:SGTC_1664|Compound:st014217|FD-Score:-2.91|P-value:4.48E-4 ID:SGTC_2113|Compound:5491891|FD-Score:2.74|P-value:8.59E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.79|P-value:7.54E-6 ID:SGTC_2160|Compound:5660466|FD-Score:5.41|P-value:3.23E-10 ID:SGTC_2170|Compound:morpholine|FD-Score:3.65|P-value:1.50E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.24|P-value:1.07E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.57|P-value:2.26E-5 ID:SGTC_2470|Compound:5664817|FD-Score:2.97|P-value:3.52E-4 ID:SGTC_2479|Compound:5617353|FD-Score:2.78|P-value:7.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.10|P-value:2.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.15|P-value:1.68E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.02|P-value:2.78E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-2.93|P-value:4.16E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.06|P-value:2.45E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.96|P-value:3.79E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-2.74|P-value:9.06E-4 ID:SGTC_2842|Compound:9000675|FD-Score:2.94|P-value:3.98E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.72|P-value:9.48E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.80|P-value:7.12E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.07|P-value:2.25E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.82|P-value:1.91E-8 ID:SGTC_2940|Compound:9060638|FD-Score:4.12|P-value:1.30E-6 ID:SGTC_2955|Compound:9076254|FD-Score:2.97|P-value:3.43E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-8.09|P-value:1.32E-20 ID:SGTC_2965|Compound:9082772|FD-Score:5.05|P-value:3.97E-9 ID:SGTC_3108|Compound:9121785|FD-Score:3.01|P-value:2.91E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.76|P-value:8.62E-6

Top fitness defect scores for YER057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_424 splitomicin 8.58 100.0 mM 5.85E-23 1 4.68E-18
2 SGTC_1634 st006576 5.63 41.0 µM 6.68E-11 TSC3-RPN4 6 9.25E-9
3 SGTC_2160 5660466 5.41 132.9 µM 3.23E-10 60S ribosome export 1 3.13E-8
4 SGTC_2965 9082772 5.05 38.6 µM 3.97E-9 mitochondrial response to ROS 19 2.18E-7
5 SGTC_943 3253-1379 4.48 105.0 µM 1.53E-7 18 3.68E-6
6 SGTC_380 3970-0968 4.13 6.0 µM 1.21E-6 10 1.83E-5
7 SGTC_2940 9060638 4.12 45.9 µM 1.30E-6 amide catabolism 21 1.93E-5
8 SGTC_1529 apigenin 3.87 74.0 µM 4.85E-6 37 5.37E-5
9 SGTC_391 gliotoxin 3.87 8.3 µM 5.06E-6 67 5.55E-5
10 SGTC_2121 5257820 3.79 149.6 µM 7.54E-6 12 7.56E-5
11 SGTC_3135 9127742 3.76 49.5 µM 8.62E-6 28 8.40E-5
12 SGTC_2170 morpholine 3.65 200.0 µM 1.50E-5 15 1.29E-4
13 SGTC_705 1124-0212 3.62 310.0 µM 1.76E-5 24 1.47E-4
14 SGTC_2457 5731572 3.57 11.7 µM 2.26E-5 22 1.78E-4
15 SGTC_942 3253-1115 3.57 227.0 µM 2.29E-5 42 1.79E-4
16 SGTC_2353 9059630 3.24 146.7 µM 1.07E-4 34 5.96E-4
17 SGTC_373 0844-0104 3.08 25.9 µM 2.18E-4 ERAD & cell cycle 103 0.00104
18 SGTC_2916 7875993 3.07 68.8 µM 2.25E-4 67 0.00107
19 SGTC_6 0844-0013 3.06 19.8 µM 2.41E-4 204 0.00112
20 SGTC_1144 3486-0183 3.02 12.5 µM 2.75E-4 63 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.32E-22 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.147 1.01E-17 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.129 5.66E-14 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.114 3.76E-11 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.109 2.77E-10 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.105 9.10E-10 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.100 5.62E-9 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.095 3.31E-8 YBR271W EFM2 hom S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
0.094 4.24E-8 YNL066W SUN4 hom Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
0.094 4.45E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.090 1.81E-7 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.089 2.84E-7 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.086 5.72E-7 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.086 6.22E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.086 6.58E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm