YER060W-A / FCY22

Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER060W-A / FCY22

Click on Significant Values for Screen Details ID:SGTC_592|Compound:k241-0073|FD-Score:4.44|P-value:9.53E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:2.91|P-value:8.60E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.90|P-value:1.34E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.50|P-value:1.20E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:2.90|P-value:8.73E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.18|P-value:4.46E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.46|P-value:1.49E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.90|P-value:2.19E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.98|P-value:1.55E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.34|P-value:2.48E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.10|P-value:6.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:2.61E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.08|P-value:6.67E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.01|P-value:8.36E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.69|P-value:3.74E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.88|P-value:8.71E-8 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.38|P-value:2.04E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.69|P-value:2.50E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:-7.57|P-value:7.68E-16 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.26|P-value:4.13E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.51|P-value:1.23E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.59|P-value:8.87E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.82|P-value:2.05E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.14|P-value:3.61E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.88|P-value:9.57E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.52|P-value:7.72E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.82|P-value:3.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.02|P-value:6.81E-8 ID:SGTC_2018|Compound:5133068|FD-Score:2.91|P-value:8.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.79|P-value:2.37E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.90|P-value:8.78E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.17|P-value:4.75E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.18|P-value:4.45E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-7.73|P-value:2.02E-16 ID:SGTC_2478|Compound:5763493|FD-Score:-3.23|P-value:3.79E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.82|P-value:2.06E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.04|P-value:7.72E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-2.99|P-value:9.13E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.99|P-value:8.99E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.51|P-value:1.21E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.30|P-value:2.85E-4 ID:SGTC_3259|Compound:9138485|FD-Score:2.91|P-value:8.70E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.08|P-value:6.65E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.74|P-value:4.58E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.15|P-value:6.87E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.44|P-value:9.53E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:2.91|P-value:8.60E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.90|P-value:1.34E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.50|P-value:1.20E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:2.90|P-value:8.73E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.18|P-value:4.46E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.46|P-value:1.49E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.90|P-value:2.19E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.65|P-value:4.48E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.98|P-value:1.55E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.34|P-value:2.48E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.10|P-value:6.04E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:2.61E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.08|P-value:6.67E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.01|P-value:8.36E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.69|P-value:3.74E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:4.88|P-value:8.71E-8 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.38|P-value:2.04E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.69|P-value:2.50E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:-7.57|P-value:7.68E-16 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.26|P-value:4.13E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.51|P-value:1.23E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.59|P-value:8.87E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.82|P-value:2.05E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.14|P-value:3.61E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.88|P-value:9.57E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.52|P-value:7.72E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.82|P-value:3.23E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.02|P-value:6.81E-8 ID:SGTC_2018|Compound:5133068|FD-Score:2.91|P-value:8.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.79|P-value:2.37E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.90|P-value:8.78E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.17|P-value:4.75E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.18|P-value:4.45E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-7.73|P-value:2.02E-16 ID:SGTC_2478|Compound:5763493|FD-Score:-3.23|P-value:3.79E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.82|P-value:2.06E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.04|P-value:7.72E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-2.99|P-value:9.13E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.24|P-value:2.44E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.99|P-value:8.99E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.51|P-value:1.21E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.30|P-value:2.85E-4 ID:SGTC_3259|Compound:9138485|FD-Score:2.91|P-value:8.70E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.08|P-value:6.65E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.74|P-value:4.58E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-4.15|P-value:6.87E-6 ID:SGTC_3315|Compound:9136395|FD-Score:3.43|P-value:1.11E-4

Top fitness defect scores for YER060W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1209 2323-2347 4.88 50.3 µM 8.71E-8 8 5.30E-7
2 SGTC_1456 k015-0012 4.69 13.0 µM 2.50E-7 15 1.35E-6
3 SGTC_592 k241-0073 4.44 46.5 µM 9.53E-7 14 4.41E-6
4 SGTC_1831 st055328 3.82 12.0 µM 2.05E-5 heme biosynthesis & mitochondrial translocase 32 6.66E-5
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.82 3.7 µM 2.06E-5 92 6.70E-5
6 SGTC_2310 7668677 3.79 200.0 µM 2.37E-5 35 7.57E-5
7 SGTC_1207 2099-0101 3.69 141.0 µM 3.74E-5 27 1.14E-4
8 SGTC_821 1114-0266 3.65 29.2 µM 4.48E-5 28 1.33E-4
9 SGTC_1909 st060837 3.52 51.5 µM 7.72E-5 71 2.15E-4
10 SGTC_3315 9136395 3.43 68.5 µM 1.11E-4 20 2.97E-4
11 SGTC_1208 2323-2347 3.37 50.3 µM 1.43E-4 20 3.73E-4
12 SGTC_2546 rhodinyl acetate 3.24 100.0 µM 2.44E-4 30 5.96E-4
13 SGTC_1842 st055362 3.14 61.2 µM 3.61E-4 42 8.42E-4
14 SGTC_1731 st035964 3.09 63.0 µM 4.44E-4 74 0.00101
15 SGTC_1181 1222-0449 3.07 220.0 µM 4.64E-4 58 0.00105
16 SGTC_2018 5133068 2.91 143.0 µM 8.51E-4 79 0.00180
17 SGTC_603 3794-0023 2.91 45.9 µM 8.60E-4 43 0.00182
18 SGTC_3259 9138485 2.91 49.5 µM 8.70E-4 54 0.00184
19 SGTC_745 0469-0705 2.90 296.0 µM 8.73E-4 mitochondrial processes 70 0.00184
20 SGTC_2313 7726885 2.90 200.0 µM 8.78E-4 RPP1 & pyrimidine depletion 82 0.00185

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 3.75E-63 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.280 1.65E-61 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.268 5.38E-56 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.255 6.34E-51 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.250 6.82E-49 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.228 9.73E-41 YMR019W STB4 hom Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;
0.224 2.56E-39 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.222 1.46E-38 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.218 3.15E-37 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.208 4.56E-34 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.204 8.74E-33 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.199 2.24E-31 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.193 1.71E-29 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.193 2.42E-29 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.191 9.47E-29 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants