YER061C / CEM1

Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration

Zygosity: Homozygous strain
fixedexpanded
Profile for YER061C / CEM1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.10|P-value:8.15E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:4.59|P-value:1.09E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:4.94|P-value:2.45E-6 ID:SGTC_34|Compound:0469-0683|FD-Score:6.68|P-value:3.15E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:5.55|P-value:1.43E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.82|P-value:2.09E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.68|P-value:7.61E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:3.68|P-value:3.35E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.49|P-value:6.38E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.53|P-value:5.50E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.82|P-value:2.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.47|P-value:6.83E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.25|P-value:3.72E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.85|P-value:3.08E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:3.58|P-value:4.70E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:17.00|P-value:2.80E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.37|P-value:3.39E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:7.05|P-value:3.46E-11 ID:SGTC_283|Compound:0987-0079|FD-Score:5.55|P-value:1.45E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.33|P-value:9.34E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.94|P-value:2.46E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.43|P-value:7.68E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:6.19|P-value:5.03E-9 ID:SGTC_683|Compound:panaxydol|FD-Score:5.08|P-value:1.29E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.48|P-value:6.49E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.72|P-value:3.00E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.11|P-value:7.86E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:4.01|P-value:1.05E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.39|P-value:7.79E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.91|P-value:2.37E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.95|P-value:1.30E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.38|P-value:8.99E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.76|P-value:2.57E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.99|P-value:1.13E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.87|P-value:1.74E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.88|P-value:3.21E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.00|P-value:4.66E-11 ID:SGTC_1696|Compound:st025591|FD-Score:4.04|P-value:9.53E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.49|P-value:1.45E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.37|P-value:8.38E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.86|P-value:1.80E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.10|P-value:1.22E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.42|P-value:7.86E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.60|P-value:4.37E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.07|P-value:8.47E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.43|P-value:6.92E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.88|P-value:1.70E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-4.32|P-value:2.88E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.75|P-value:2.69E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.89|P-value:1.61E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.85|P-value:1.88E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.10|P-value:8.15E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:4.59|P-value:1.09E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:4.94|P-value:2.45E-6 ID:SGTC_34|Compound:0469-0683|FD-Score:6.68|P-value:3.15E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:5.55|P-value:1.43E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.82|P-value:2.09E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.68|P-value:7.61E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:3.68|P-value:3.35E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.49|P-value:6.38E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.53|P-value:5.50E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.82|P-value:2.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.47|P-value:6.83E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.25|P-value:3.72E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.85|P-value:3.08E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:3.58|P-value:4.70E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:17.00|P-value:2.80E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.37|P-value:3.39E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:7.05|P-value:3.46E-11 ID:SGTC_283|Compound:0987-0079|FD-Score:5.55|P-value:1.45E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.33|P-value:9.34E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.94|P-value:2.46E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.43|P-value:7.68E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:6.19|P-value:5.03E-9 ID:SGTC_683|Compound:panaxydol|FD-Score:5.08|P-value:1.29E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.48|P-value:6.49E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.72|P-value:3.00E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.11|P-value:7.86E-9 ID:SGTC_949|Compound:1165-0505|FD-Score:4.01|P-value:1.05E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.39|P-value:7.79E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.91|P-value:2.37E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.95|P-value:1.30E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.38|P-value:8.99E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.76|P-value:2.57E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.99|P-value:1.13E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.87|P-value:1.74E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.88|P-value:3.21E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.00|P-value:4.66E-11 ID:SGTC_1696|Compound:st025591|FD-Score:4.04|P-value:9.53E-5 ID:SGTC_1731|Compound:st035964|FD-Score:-4.49|P-value:1.45E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.37|P-value:8.38E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.86|P-value:1.80E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.10|P-value:1.22E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.42|P-value:7.86E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.60|P-value:4.37E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.07|P-value:8.47E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.43|P-value:6.92E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.88|P-value:1.70E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-4.32|P-value:2.88E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.75|P-value:2.69E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.89|P-value:1.61E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.85|P-value:1.88E-4

Top fitness defect scores for YER061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 17.00 5.3 µM 2.80E-56 76 3.82E-65
2 SGTC_279 1273-0055 7.05 2.9 µM 3.46E-11 azole & statin 5 9.17E-13
3 SGTC_1635 st007035 7.00 42.4 µM 4.66E-11 114 1.30E-12
4 SGTC_34 0469-0683 6.68 81.8 µM 3.15E-10 SWF1 & branched chain AA biosynthesis 8 1.19E-11
5 SGTC_134 0269-0018 6.25 6.9 µM 3.72E-9 77 2.09E-10
6 SGTC_609 0986-0026 6.19 86.3 µM 5.03E-9 calcium & mitochondrial duress 5 2.96E-10
7 SGTC_902 1120-0002 6.11 2.1 µM 7.86E-9 azole & statin 19 4.97E-10
8 SGTC_7 0192-1582 6.10 4.2 µM 8.15E-9 24 5.19E-10
9 SGTC_163 1327-0036 5.85 7.5 µM 3.08E-8 52 2.43E-9
10 SGTC_59 0330-0160 5.68 1.3 µM 7.61E-8 47 6.93E-9
11 SGTC_36 0335-0881 5.55 14.2 µM 1.43E-7 ubiquinone biosynthesis & proteasome 73 1.44E-8
12 SGTC_283 0987-0079 5.55 11.7 µM 1.45E-7 6 1.47E-8
13 SGTC_275 trichlorophene 5.37 5.7 µM 3.39E-7 mitochondrial stress 145 3.92E-8
14 SGTC_2627 acetyl isogambogic acid 5.10 100.0 µM 1.22E-6 TSC3-RPN4 26 1.73E-7
15 SGTC_683 panaxydol 5.08 45.0 µM 1.29E-6 sphingolipid biosynthesis & PDR1 19 1.85E-7
16 SGTC_18 0111-0177 4.94 500.0 nM 2.45E-6 38 3.87E-7
17 SGTC_350 k064-0020 4.94 19.8 µM 2.46E-6 heme requiring 15 3.89E-7
18 SGTC_1568 digitonin 4.88 820.0 nM 3.21E-6 sphingolipid biosynthesis & PDR1 18 5.31E-7
19 SGTC_8 0354-0001 4.59 70.0 µM 1.09E-5 55 2.18E-6
20 SGTC_171 k064-0041 4.51 9.7 µM 1.53E-5 heme requiring 22 3.25E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.459 1.26E-174 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.451 7.57E-168 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.444 2.88E-162 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.437 3.09E-156 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.436 1.30E-155 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.434 5.80E-154 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.430 1.71E-151 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.429 3.44E-150 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.428 1.18E-149 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.426 3.88E-148 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.422 8.19E-145 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.415 7.48E-140 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.413 1.22E-138 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.411 7.59E-137 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.407 2.19E-134 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies