HIPHOP chemogenomics database

YER061C / CEM1

Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration

Zygosity: Homozygous strain

fixedexpanded
Profile for YER061C / CEM1

Click on Significant Values for Screen Details

Top fitness defect scores for YER061C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	17.00	5.3 µM	2.80E-56		76	3.82E-65
2	SGTC_279	1273-0055	7.05	2.9 µM	3.46E-11	azole & statin	5	9.17E-13
3	SGTC_1635	st007035	7.00	42.4 µM	4.66E-11		114	1.30E-12
4	SGTC_34	0469-0683	6.68	81.8 µM	3.15E-10	SWF1 & branched chain AA biosynthesis	8	1.19E-11
5	SGTC_134	0269-0018	6.25	6.9 µM	3.72E-9		77	2.09E-10
6	SGTC_609	0986-0026	6.19	86.3 µM	5.03E-9	calcium & mitochondrial duress	5	2.96E-10
7	SGTC_902	1120-0002	6.11	2.1 µM	7.86E-9	azole & statin	19	4.97E-10
8	SGTC_7	0192-1582	6.10	4.2 µM	8.15E-9		24	5.19E-10
9	SGTC_163	1327-0036	5.85	7.5 µM	3.08E-8		52	2.43E-9
10	SGTC_59	0330-0160	5.68	1.3 µM	7.61E-8		47	6.93E-9
11	SGTC_36	0335-0881	5.55	14.2 µM	1.43E-7	ubiquinone biosynthesis & proteasome	73	1.44E-8
12	SGTC_283	0987-0079	5.55	11.7 µM	1.45E-7		6	1.47E-8
13	SGTC_275	trichlorophene	5.37	5.7 µM	3.39E-7	mitochondrial stress	145	3.92E-8
14	SGTC_2627	acetyl isogambogic acid	5.10	100.0 µM	1.22E-6	TSC3-RPN4	26	1.73E-7
15	SGTC_683	panaxydol	5.08	45.0 µM	1.29E-6	sphingolipid biosynthesis & PDR1	19	1.85E-7
16	SGTC_18	0111-0177	4.94	500.0 nM	2.45E-6		38	3.87E-7
17	SGTC_350	k064-0020	4.94	19.8 µM	2.46E-6	heme requiring	15	3.89E-7
18	SGTC_1568	digitonin	4.88	820.0 nM	3.21E-6	sphingolipid biosynthesis & PDR1	18	5.31E-7
19	SGTC_8	0354-0001	4.59	70.0 µM	1.09E-5		55	2.18E-6
20	SGTC_171	k064-0041	4.51	9.7 µM	1.53E-5	heme requiring	22	3.25E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.459	1.26E-174	YFL018C	LPD1	hom	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
0.451	7.57E-168	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.444	2.88E-162	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.437	3.09E-156	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.436	1.30E-155	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.434	5.80E-154	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.430	1.71E-151	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.429	3.44E-150	YJL046W	AIM22	hom	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.428	1.18E-149	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.426	3.88E-148	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.422	8.19E-145	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.415	7.48E-140	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.413	1.22E-138	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.411	7.59E-137	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.407	2.19E-134	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies