HIPHOP chemogenomics database

YER066C-A_d

Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W

Zygosity: Homozygous strain

fixedexpanded
Profile for YER066C-A / YER066C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YER066C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2788	5282734	5.06	71.4 µM	2.74E-8		22	2.08E-7
2	SGTC_1673	st016611	4.63	27.3 µM	3.24E-7		27	1.80E-6
3	SGTC_2479	5617353	4.54	43.9 µM	5.54E-7		19	2.87E-6
4	SGTC_539	4859-0462	4.03	2.5 µM	7.57E-6	RNA pol III & RNase P/MRP	24	2.83E-5
5	SGTC_1121	fusaric acid	3.95	630.5 nM	1.09E-5		33	3.90E-5
6	SGTC_1524	corynanthine	3.84	62.1 µM	1.85E-5		21	6.19E-5
7	SGTC_996	3970-0799	3.76	1.8 µM	2.63E-5		89	8.40E-5
8	SGTC_1571	st070080	3.39	73.4 µM	1.31E-4		31	3.44E-4
9	SGTC_2612	dictamnine	3.39	15.5 µM	1.33E-4	RNA pol III & RNase P/MRP	69	3.48E-4
10	SGTC_1654	st012436	3.38	41.8 µM	1.42E-4		28	3.69E-4
11	SGTC_1689	st020265	3.33	53.5 µM	1.71E-4		31	4.32E-4
12	SGTC_2608	thymoquinone	3.29	42.7 µM	2.00E-4		36	4.96E-4
13	SGTC_3300	9124615	3.27	50.5 µM	2.22E-4		43	5.45E-4
14	SGTC_1569	carminic acid	3.25	40.6 µM	2.37E-4		42	5.76E-4
15	SGTC_1751	st044839	3.25	27.2 µM	2.41E-4	Golgi	25	5.84E-4
16	SGTC_133	0724-0033	3.21	378.9 µM	2.80E-4		52	6.67E-4
17	SGTC_398	bronopol	3.18	33.3 µM	3.14E-4	RNA processing & uracil transport	52	7.37E-4
18	SGTC_1239	0337-0584	3.18	35.4 µM	3.15E-4	unfolded protein response	93	7.39E-4
19	SGTC_1620	st003704	2.98	16.5 µM	6.73E-4		45	0.00144
20	SGTC_299	1273-0059	2.97	1.4 µM	7.02E-4		59	0.00149

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.179	1.61E-25	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141	1.85E-16	YMR127C	SAS2	hom	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.141	1.94E-16	YJR038C_d	YJR038C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131	2.21E-14	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.122	1.50E-12	YBR050C	REG2	hom	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.121	2.33E-12	YDR315C	IPK1	hom	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.119	4.91E-12	YGL096W	TOS8	hom	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.119	5.50E-12	YKL010C	UFD4	hom	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.117	1.14E-11	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.115	2.36E-11	YJL137C	GLG2	hom	Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.113	5.27E-11	YML130C	ERO1	het	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.111	9.69E-11	YMR006C	PLB2	hom	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.108	3.37E-10	YGL040C	HEM2	het	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.107	5.34E-10	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.106	7.89E-10	YJL149W	DAS1	hom	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C