YER066C-A_d

Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W

Zygosity: Homozygous strain
fixedexpanded
Profile for YER066C-A / YER066C-A

Click on Significant Values for Screen Details ID:SGTC_133|Compound:0724-0033|FD-Score:3.21|P-value:2.80E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.97|P-value:7.02E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-6.16|P-value:2.33E-11 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.89|P-value:1.61E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.18|P-value:3.14E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.12|P-value:4.32E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.49|P-value:9.89E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.03|P-value:7.57E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.76|P-value:2.63E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.95|P-value:1.09E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.93|P-value:8.02E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.84|P-value:2.12E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.84|P-value:1.85E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.25|P-value:2.37E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1620|Compound:st003704|FD-Score:2.98|P-value:6.73E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.92|P-value:1.42E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-2.92|P-value:9.20E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.38|P-value:1.42E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.63|P-value:3.24E-7 ID:SGTC_1689|Compound:st020265|FD-Score:3.33|P-value:1.71E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.25|P-value:2.41E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.32|P-value:1.95E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.54|P-value:5.54E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.29|P-value:2.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.06|P-value:2.74E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-5.69|P-value:5.95E-10 ID:SGTC_2996|Compound:9066192|FD-Score:-2.94|P-value:8.64E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.27|P-value:2.22E-4 ID:SGTC_3337|Compound:9144342|FD-Score:2.95|P-value:7.45E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.21|P-value:2.80E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:2.97|P-value:7.02E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-6.16|P-value:2.33E-11 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.89|P-value:1.61E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.18|P-value:3.14E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.12|P-value:4.32E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.49|P-value:9.89E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.03|P-value:7.57E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.76|P-value:2.63E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.95|P-value:1.09E-5 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.93|P-value:8.02E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.84|P-value:2.12E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.84|P-value:1.85E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.25|P-value:2.37E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1620|Compound:st003704|FD-Score:2.98|P-value:6.73E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.92|P-value:1.42E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-2.92|P-value:9.20E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.38|P-value:1.42E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.63|P-value:3.24E-7 ID:SGTC_1689|Compound:st020265|FD-Score:3.33|P-value:1.71E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.25|P-value:2.41E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.32|P-value:1.95E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.54|P-value:5.54E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.29|P-value:2.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.06|P-value:2.74E-8 ID:SGTC_2990|Compound:9074105|FD-Score:-5.69|P-value:5.95E-10 ID:SGTC_2996|Compound:9066192|FD-Score:-2.94|P-value:8.64E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.27|P-value:2.22E-4 ID:SGTC_3337|Compound:9144342|FD-Score:2.95|P-value:7.45E-4

Top fitness defect scores for YER066C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2788 5282734 5.06 71.4 µM 2.74E-8 22 2.08E-7
2 SGTC_1673 st016611 4.63 27.3 µM 3.24E-7 27 1.80E-6
3 SGTC_2479 5617353 4.54 43.9 µM 5.54E-7 19 2.87E-6
4 SGTC_539 4859-0462 4.03 2.5 µM 7.57E-6 RNA pol III & RNase P/MRP 24 2.83E-5
5 SGTC_1121 fusaric acid 3.95 630.5 nM 1.09E-5 33 3.90E-5
6 SGTC_1524 corynanthine 3.84 62.1 µM 1.85E-5 21 6.19E-5
7 SGTC_996 3970-0799 3.76 1.8 µM 2.63E-5 89 8.40E-5
8 SGTC_1571 st070080 3.39 73.4 µM 1.31E-4 31 3.44E-4
9 SGTC_2612 dictamnine 3.39 15.5 µM 1.33E-4 RNA pol III & RNase P/MRP 69 3.48E-4
10 SGTC_1654 st012436 3.38 41.8 µM 1.42E-4 28 3.69E-4
11 SGTC_1689 st020265 3.33 53.5 µM 1.71E-4 31 4.32E-4
12 SGTC_2608 thymoquinone 3.29 42.7 µM 2.00E-4 36 4.96E-4
13 SGTC_3300 9124615 3.27 50.5 µM 2.22E-4 43 5.45E-4
14 SGTC_1569 carminic acid 3.25 40.6 µM 2.37E-4 42 5.76E-4
15 SGTC_1751 st044839 3.25 27.2 µM 2.41E-4 Golgi 25 5.84E-4
16 SGTC_133 0724-0033 3.21 378.9 µM 2.80E-4 52 6.67E-4
17 SGTC_398 bronopol 3.18 33.3 µM 3.14E-4 RNA processing & uracil transport 52 7.37E-4
18 SGTC_1239 0337-0584 3.18 35.4 µM 3.15E-4 unfolded protein response 93 7.39E-4
19 SGTC_1620 st003704 2.98 16.5 µM 6.73E-4 45 0.00144
20 SGTC_299 1273-0059 2.97 1.4 µM 7.02E-4 59 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.61E-25 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141 1.85E-16 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.141 1.94E-16 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.21E-14 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.122 1.50E-12 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.121 2.33E-12 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.119 4.91E-12 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.119 5.50E-12 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.14E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.115 2.36E-11 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.113 5.27E-11 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.111 9.69E-11 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.108 3.37E-10 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.107 5.34E-10 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.106 7.89E-10 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C