HIPHOP chemogenomics database
YER066W_p / RRT13 
Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YER066W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.469 | 5.02E-183 | YLR395C | COX8 | hom | Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| 0.448 | 1.64E-165 | YGL146C_p | RRT6_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins |
| 0.396 | 2.09E-126 | YGR015C_p | YGR015C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion |
| 0.350 | 2.28E-97 | YJL043W_p | YJL043W_p | hom | Putative protein of unknown function; YJL043W is a non-essential gene |
| 0.335 | 1.55E-88 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.324 | 5.59E-83 | YER068W | MOT2 | hom | Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications |
| 0.322 | 8.74E-82 | YNL220W | ADE12 | hom | Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence |
| 0.314 | 1.88E-77 | YEL049W | PAU2 | hom | Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |
| 0.305 | 1.93E-73 | YGL144C | ROG1 | hom | Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication |
| 0.301 | 3.77E-71 | YOR300W_d | YOR300W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 |
| 0.298 | 5.28E-70 | YIL115C | NUP159 | het | FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) |
| 0.296 | 6.20E-69 | YNR067C | DSE4 | hom | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother |
| 0.270 | 3.51E-57 | YPL100W | ATG21 | hom | Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein |
| 0.268 | 4.86E-56 | YER071C_p | TDA2_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele |
| 0.255 | 7.38E-51 | YAL004W_d | YAL004W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C |